Emendo Biotherapeutics, Inc.

EmendoBio’s technology will aid Anocca in delivering tailored therapies to patients more rapidly. Credit: Natali _ Mis / Shutterstock.com. Swedish biotech company Anocca has entered a non-exclusive licensing agreement with EmendoBio to use the latter’s OMNI-A4 nuclease, a gene editing technology [that cleaves chains of nucleotides in nucleic acids into smaller units]. This strategic move is set to expedite developing and manufacturing Anocca’s pipeline of T cell receptor-engineered T cell (TCR-T) therapies, targeting difficult-to-treat solid cancers. The latest development comes after Anocca received good manufacturing practice compliance certification and a manufacturing licence from regulators in Sweden for its cell therapy production facility. Anocca CEO and co-founder Reagan Jarvis stated: “Integrating EmendoBio’s nuclease into our manufacturing process supports Anocca’s aim of generating the highest-quality cell therapy products. “This next-generation gene editing system provides the precision and efficiency needed to scale out production of our growing libraries of TCR-T products in a high-precision manufacturing process. See Also: Eli Lilly-backed Zephyr AI secures $111m for precision medicine tech Almirall to license Eloxx’s ZKN-013 for rare skin conditions “We are excited to work with EmendoBio to develop gene-edited TCR-T cell therapies as we prepare for our first clinical programme targeting the KRAS driver mutation in a hard-to-treat solid cancer.” EmendoBio’s technology is expected to significantly enhance Anocca’s manufacturing expertise. It will also aid the company in delivering tailored therapies to patients more rapidly, focusing on the genetic causes of hard-to-treat cancer types. The licensed gene editing technology is part of EmendoBio’s nuclease suite designed for high activity and specificity within cell therapy applications. EmendoBio director Dr Ei Yamada stated: “This non-exclusive licensing agreement marks a significant milestone in the field of T cell therapy. “Together with Anocca, we are embracing the shared vision of harnessing the potential of gene editing and cellular therapies to make a profound impact on patient outcomes. Our combined expertise will unlock novel avenues for therapeutic development and push the boundaries of what’s possible in advanced medicine.” In May 2023, Anocca secured Skr400m ($38.9m) in an equity financing round to develop next-generation cell therapies for cancer on an industrial scale. AMF and Mellby Gård led the funding round. Cell & Gene Therapy coverage on Pharmaceutical Technology is supported by Cytiva. Editorial content is independently produced and follows the highest standards of journalistic integrity. Topic sponsors are not involved in the creation of editorial content. Free Whitepaper Cell and gene therapies: Pipe dream to pipeline The cell and gene industry is gaining momentum, with a new wave of therapies promising to transform the way doctors treat, and even cure, disease. In this report, Cytiva and GlobalData have collaborated to explore the rise of the cell and gene therapy industries, the current state of the market, present and future opportunities for advancement, and the challenges that lie ahead. By Cytiva Thematic By downloading this case study, you acknowledge that GlobalData may share your information with Cytiva Thematic and that your personal data will be used as described in their Privacy Policy

Enabling Technology Supports the Development of Anocca’s Deep Pipeline of TCR-T therapeutics NEW YORK and SÖDERTÄLJE, Sweden, March 14, 2024 (GLOBE NEWSWIRE) -- Anocca AB (Anocca), a leading T cell receptor-engineered T cell (TCR-T) cellular therapeutics company, and EmendoBio Inc. (EmendoBio), a nuclease discovery and gene editing therapeutics company, today announced a non-exclusive licensing agreement for the use of EmendoBio’s novel OMNI-A4 nuclease to accelerate the manufacture and development of Anocca’s deep pipeline of TCR-T cell therapies for difficult-to-treat solid cancers. “Integrating EmendoBio’s nuclease into our manufacturing process supports Anocca’s aim of generating the highest-quality cell therapy products. This next-generation gene editing system provides the precision and efficiency needed to scale out production of our growing libraries of TCR-T products in a high-precision manufacturing process. We are excited to work with EmendoBio to develop gene-edited TCR-T cell therapies as we prepare for our first clinical program targeting the KRAS driver mutation in a hard-to-treat solid cancer” said Anocca’s CEO and co-founder, Reagan Jarvis. “This non-exclusive licensing agreement marks a significant milestone in the field of T cell therapy,” said Dr. Ei Yamada, Director of EmendoBio. “Together with Anocca, we are embracing the shared vision of harnessing the potential of gene editing and cellular therapies to make a profound impact on patient outcomes. Our combined expertise will unlock novel avenues for therapeutic development and push the boundaries of what's possible in advanced medicine.” Anocca recently received certification of GMP compliance and a manufacturing license from the Swedish regulators for their cell therapy production facility, the largest in the Nordics. EmendoBio’s technology strengthens Anocca’s manufacturing capability and provides a foundation for the ambitious goal of reaching more patients faster with personalised treatments targeting the underlying genetic drivers of hard-to-treat cancers. The licensed gene editing technology is part of EmendoBio’s portfolio of proprietary nucleases developed to be highly active and specific for cell therapy applications. Anocca’s and Emendo’s commitment to innovation and scientific excellence sets the stage for a promising future in T cell therapies. The agreement not only underscores the significance of collaborative efforts in the biotechnology sector but also reinforces both companies' dedication to improving global healthcare outcomes. Notes to editors About EmendoBio EmendoBio is a next-generation CRISPR gene editing company leveraging its proprietary technology to enable high precision gene editing, which is critical for the development of safe medical applications of genome editing. Driven by cutting-edge computational biology, novel gene editing strategies, and the latest of protein engineering tools, EmendoBio’s novel nuclease discovery platform, OMNI, broadens the targetable range of the genome, while its target-specific optimisation platform enables highly precise editing that maintains high efficiencies. EmendoBio’s proprietary OMNI nucleases also are designed to reduce "off-target” effects, i.e., cleavage at locations other than the targeted genes. Achieving such pinpoint precision is a substantial challenge for genome editing therapies. The capabilities of the OMNI technology platform, along with deep expertise in genomic medicine and protein engineering, provide EmendoBio with a unique advantage when addressing indications, including within haematology, cardiovascular, ophthalmology, oncology, and other disease areas. About Anocca Anocca is a fully integrated biopharmaceutical company developing libraries of T cell receptor-engineered T cell (TCR-T) therapies to redefine the treatment of solid tumours. Its proprietary technologies have been designed to vastly expand TCR-T development, allowing the systematic generation of treatments for the broadest patient populations that equip the immune system against the most difficult to treat solid cancers. Anocca operates an advanced research and development infrastructure, underpinned by a custom software ecosystem and in-house clinical manufacturing and process development facilities. Its unique discovery platform uses programmable human cells to recreate and manipulate T cell immunity. Follow Anocca on LinkedIn and visit . Media Inquiries Anocca AB Mark Farmery, CDO media@anocca.com Scius Communications (for Anocca AB) Katja Stout Tel: +44 7789 435 990 katja@sciuscommunications.com Daniel Gooch Tel: +44 7747 875 479 daniel@sciuscommunications.com EmendoBio Inc. Naoya Satoh, CEO Tel: +81 3 5730 2480 nsato@emendobio.com Noa Wertheimer Tel: +972 54 6437741 noaw@emendobio.com

CAMBRIDGE, United Kingdom and NEW YORK, Feb. 07, 2024 (GLOBE NEWSWIRE) -- Artios Pharma Limited (“Artios”), clinical-stage biotech company led by pioneers of DNA damage response (“DDR”) drug development, announces the appointment of Christine Silverstein as Chief Financial Officer (CFO). Christine joins Artios with more than 15 years of diversified finance, corporate strategy, and business development experience in the biopharmaceutical industry. Niall Martin, Chief Executive Officer of Artios, said: “Christine is a seasoned CFO with robust capital markets expertise and a deep understanding of the industry landscape. We are pleased to welcome her to the Artios executive team where she will play a key leadership role in the U.S. and further strengthen our global presence. Importantly, her track record of raising capital, preparing companies for IPO, and experience with partnerships and M&A will position us for success as we continue to advance our leading DDR pipeline.” Before joining Artios, Christine most recently held executive leadership roles at Excision Biotherapeutics, Inc. and Emendo Biotherapeutics, where she successfully led financial strategy and corporate partnering, improved operational efficiency, and facilitated substantial growth. She will join the Company’s U.S. subsidiary in the New York office. Christine Silverstein, Chief Financial Officer of Artios, added: “As recognized innovators in DDR drug discovery, Artios’ advanced pipeline targeting the DNA damage response offers cutting-edge approaches for difficult-to-treat cancers. I am excited to join Artios at this pivotal time, with clinical data expected for lead programs including ATR inhibitor ART0380 and novel Pol theta inhibitor ART6043 over the next 12 months. I look forward to partnering with the Artios team as we approach this next stage of growth and work to advance potentially life-extending therapies for the treatment of a broad range of solid tumors.” Christine Silverstein has over 15 years of financial leadership experience spanning strategic and operational roles across both private and public biopharmaceutical companies. Prior to joining Artios, she most recently served as CFO of Excision Biotherapeutics, Inc., where she established numerous corporate functions and led financial planning, strategy, and initial public offering (IPO) readiness activities. Formerly as CFO of Emendo Biotherapeutics (acquired in December 2020 by AnGes, Inc.), Silverstein established the Company’s U.S. operations and capital market footprint for IPO preparedness as well as completed the M&A transaction. During her time at Abeona Therapeutics, Silverstein operated in multiple senior executive roles including CFO and Principal Financial Officer. Earlier in her career, she drove internal capital markets strategy at Relmada Therapeutics, Inc., and held senior executive roles within biotechnology venture fund SCO Capital Partners. Silverstein began her career in the financial services industry where she was instrumental in advising clients on transaction considerations and formulating effective U.S. public listing and financing strategies. Silverstein currently serves on the board of directors at Marinus Pharmaceuticals and Abeona Therapeutics Inc. Silverstein holds a B.S. from the Peter Tobin College of Business at St. John’s University and has earned various accreditations from the Financial Industry Regulatory Authority (FINRA) and Harvard University. About Artios Artios is on a mission to kill cancer by exploiting DNA damage response (DDR) and repair pathways that are leveraged by cancer cells to promote their survival. Our specialized DcoDeR platform integrates Artios’ leadership capabilities, expertise and experience in DNA damage biology and drug discovery to systematically discover and develop medicines targeting the totality of the DDR. We have built an extensive DDR focused pipeline designed to address areas of high unmet needs across solid tumour indications including our ATR inhibitor, ART0380, and our Polθ inhibitors, ART4215 and ART6043, as monotherapies and with combination treatments. Together with our strategic partnerships with Merck KGaA and Novartis, and research collaborations with premiere institutions like Cancer Research UK, The Institute of Cancer Research, The Netherlands Cancer Institute, and the Crick Institute we are pioneering validated approaches to DDR drug discovery. Visit our website at for more information about the company and our pipeline. For more information about Artios Pharma Ltd., please contact: Investor Relations Contact: LifeSci Advisors Alexandra Folias E: afolias@lifesciadvisors.com