Article
Author: Ranjan, Rajiv ; Wibowo, Suryo Anggoro Kusumo ; Danieli, Maria Giovanna ; Nakashima, Ran ; Lini, Daniele ; Needham, Merrilee ; Madu, Nwankwo Henry ; Sebastiani, Marco ; Kimura, Naoki ; Pimentel, Victorio ; Joshi, Mrudula ; Caballero-Uribe, Carlo V ; Limaye, Vidya ; Cachafeiro-Vilar, Antonio ; Chávez, Nilmo ; Milchert, Marcin ; Gupta, Vikas ; Cavagna, Lorenzo ; Colunga-Pedraza, Iris J ; Zuleta, Wilmer Gerardo Rojas ; Chandwar, Kunal ; Morales, Roberto ; Venerito, Vincenzo ; Ho, Enrique Julio Giraldo ; Nunez, Lilith Stange ; Sierra-Zorita, Radames ; Mohammed, Reem Hamdy A ; Shumnalieva, Russka ; Giollo, Alessandro ; Traboco, Lisa S ; Ziade, Nelly ; Dey, Dzifa ; Phatak, Sanat ; Franceschini, Franco ; Gupta, Latika ; Proft, Fabian Nikolai ; Velikova, Tsvetelina ; Agarwal, Vishwesh ; Fathi, Hanan Mohammed ; Harifi, Ghita ; Hudson, Marie ; Kaneko, Yuko ; Shukla, Anuj ; Merayo-Chalico, Javier ; El Kibbi, Lina ; Baba, Zineb ; Arbeláez, Álvaro ; Asranna, Ajay ; Meyer, Alain ; Katchamart, Wanruchada ; Gono, Takahisa ; Cabriza, Karoll ; Pandya, Sapan C ; Fonseca, João Eurico ; Olaosebikan, Hakeem ; M, Idania Escalante ; Saha, Sreoshy ; Sambataro, Gianluca ; Salim, Babur ; Maurier, François ; Landon-Cardinal, Océane ; Schreiber, Karen ; Gromova, Margarita Aleksandrovna ; Distler, Oliver ; Boro, Hiya ; Knitza, Johannes ; González, Raúl ; Chowdhury, Abhra Chandra ; Langguth, Daman ; Goswami, Rudra Prosad ; Kavadichanda, Chengappa G ; Del Papa, Nicoletta ; Hidalgo, Eduardo Romero ; Zimba, Olena ; Argueta, Sandra ; Hasan, A T M Tanveer ; Airenakho, Emorinken ; Dedeke, Ibukunoluwa ; Ajmani, Sajal ; Sen, Parikshit ; Barman, Bhupen ; Patel, Aarat ; Gheita, Tamer ; Cajas, Javier ; Fabiola, Atzeni ; Pauling, John D ; Shenoy, Padnamabha ; Sebastiani, Gian Domenico ; Jain, Avinash ; Holzer, Marie-Therese ; Orsolini, Giovanni ; Pilania, Rakesh Kumar ; Yıldırım, Reşit ; Parodis, Ioannis ; Bommakanti, Keerthi Talari ; Serrano, Jorge Rojas ; Sainaghi, Pier Paolo ; Ordóñez, Andrea Bran ; Pande, Arunkumar R ; Iannone, Florenzo ; Ima-Edomwonyi, Uyi ; Wincup, Chris ; Kadam, Esha ; Arredondo, Gabriela ; Becky, A ; Tan, Chou Luan ; El bouchti, Imane ; Grignaschi, Silvia ; Shaharir, Syahrul Sazliyana ; Makol, Ashima ; Aharonov, Or ; Salinas, Rodrigo García ; Mathew, Ashish Jacob ; Govoni, Marcello ; Gracia-Ramos, Abraham Edgar ; Losanto, Jonathan ; Quezada, Ivonne ; Pellico, Maria Rosa ; Alonzo, Hugo ; Pastelin, Carlos Benito Santiago ; Silva, José António Pereira ; Chinoy, Hector ; Shinjo, Samuel Katsuyuki ; Chinchay, Lyn ; Halabi, Hussein ; Vince, Melinda Nagy ; García-De La Torre, Ignacio ; Sato, Shinji ; Singh, Yogesh Preet ; Koussougbo, Oruma Devi ; M, Cristian Vergara ; Colaman, Nelly ; Ghodke, Akanksha ; Bocci, Elena Bartoloni ; Parisi, Simone ; Palalane, Elisa ; Agarwal, Vikas ; Bautista, Generoso Guerra ; Fazal, Zoha Zahid ; Saavedra, Miguel A ; Cansu, Döndü Üsküdar ; De Angelis, Rossella ; Gasparyan, Armen Yuri ; Kardes, Sinan ; Alunno, Alessia ; Andreoli, Laura ; Yoshida, Akira ; Tomaras, Stylianos ; Hoff, Leonardo Santos ; Calapaqui, Wendy ; Giannini, Margherita ; Llerena, Gil Alberto Reyes ; Chatterjee, Tulika ; Campagne, Julien ; Toro-Gutiérrez, Carlos Enrique ; Kuwana, Masataka ; Griger, Zoltán ; Bernaola, José Proaño ; Javaid, Mahnoor ; Patro, Pradeepta Sekhar ; Gonzalez, Raquel Aranega ; Vaidya, Binit ; Obiols, Alejandro Quiñónez ; M, Manesh Manoj ; Arrieta, Dina ; Saenz, Ricardo ; Goo, Phonpen Akarawatcharangura ; Loarce-Martos, Jesús ; Hmamouchi, Ihsane ; Chibuzo, Okwara Celestine ; Chen, Yi-Ming ; Tehozol, Erick Adrian Zamora ; Tan, Ai Lyn ; Ugarte-Gil, Manuel Francisco ; Nune, Arvind ; Sharma, Aman ; Prieto-González, Sergio ; So, Ho ; Srivastav, Nilesh ; Quartuccio, Luca ; Fuentes-Silva, Yurilís ; Fusaro, Enrico ; Yerima, Abubakar ; Báez, Jossiell Then ; Nikiphorou, Elena ; Fornaro, Marco ; Day, Jessica ; Lilleker, James B
AbstractObjectiveThe presence of comorbidities can substantially affect patients’ quality of life, but data regarding their impact on idiopathic inflammatory myopathies (IIMs) are limited.MethodsWe examined the prevalence of comorbidities in IIM patients, other autoimmune rheumatic diseases (oAIRDs) and healthy controls (HCs), using data from the self-reported COVAD-2 survey. We defined basic multimorbidity (BM) as the presence of ≥2 non-rheumatic chronic conditions and complex multimorbidity (CM) as the presence of ≥3 non-rheumatic chronic conditions affecting ≥3 organ systems. Hierarchical clustering on principal components was performed for grouping.ResultsAmong the COVAD respondents, 1558 IIMs, 4591 oAIRDs and 3652 HCs were analysed. IIMs exhibited a high burden of comorbidities (odds ratio [OR]: 1.62 vs oAIRDs and 2.95 vs HCs, P < 0.01), BM (OR: 1.66 vs oAIRDs and 3.52 vs HCs, P < 0.01), CM (OR: 1.69 vs AIRDs and 6.23 vs HCs, P < 0.01) and mental health disorders (MHDs) (OR: 1.33 vs oAIRDs and 2.63 vs HCs, P < 0.01). Among the IIM patients, those with comorbidities or MHDs had lower PROMIS Global Physical (PGP), PROMIS Global Mental (PGM), and PROMIS Physical Function (SF10) scores, and higher fatigue (F4a) scores (all P < 0.001). PGP, PGM, SF10a and F4a were influenced by age, active disease, BM and MHDs. Four distinct clusters were identified among the IIMs according to comorbidities and PROMIS scores.ConclusionPatients with IIMs have a higher burden of comorbidities that influence physical and mental health, identifiable as clinical clusters for optimized and holistic management approaches.