Beijing Jinchengtaier Pharmaceutical Co., Ltd.

Primary objective: To evaluate the clinical efficacy of nifuratel-nystatin vaginal soft capsules compared to the original control drug (trade name: Maimicom®) in the treatment of vaginitis. Secondary objective: To evaluate the safety of nifuratel-nystatin vaginal soft capsules in the treatment of vaginitis.

Main purpose of the study: To study the pharmacokinetic behavior of the test preparation estradiol tablets/estradiol dydrogesterone tablets (specification: containing 2 mg estradiol and 10 mg dydrogesterone) in the combined package of estradiol tablets/estradiol dydrogesterone tablets (manufacturer: Beijing Jincheng Taier Pharmaceutical Co., Ltd.) and the reference preparation estradiol tablets/estradiol dydrogesterone tablets (trade name: Fentaton®, manufacturer: Abbott Biologicals B.V., licensee: Abbott B.V.) in healthy postmenopausal female subjects in China after a single oral dose in the fasting and postprandial states, and to evaluate the bioequivalence of the two preparations of estradiol dydrogesterone tablets in the combined package of estradiol tablets/estradiol dydrogesterone tablets. Secondary study objective: To evaluate the safety of two preparations of estradiol dydrogesterone tablets in the combined package of estradiol tablets/estradiol dydrogesterone tablets in Chinese healthy postmenopausal female subjects after a single oral administration in the fasting/postprandial state.

Primary objective: To compare the differences in the extent and rate of absorption of a single oral dose of bisoprolol fumarate tablets (specification: 5 mg) provided by Beijing Jincheng Taier Pharmaceutical Co., Ltd. and bisoprolol fumarate tablets (trade name: Concor®; specification: 5 mg) certified by Merck Serono GmbH in healthy people under fasting and fed conditions, and to evaluate the bioequivalence of the two preparations when taken orally under fasting and fed conditions. Secondary objective: To evaluate the safety and tolerability of a single oral dose of bisoprolol fumarate tablets (specification: 5 mg) provided by Beijing Jincheng Taier Pharmaceutical Co., Ltd. and bisoprolol fumarate tablets (trade name: Concor®; specification: 5 mg) certified by Merck Serono GmbH under fasting and fed conditions.