Value of Early Intervention in Smokers with Preserved Ratio Impaired Spirometry(without comorbidities) with Pulmonary Rehabilitation and Smoking Cessation - NIL

Start Date03 Oct 2024

Sponsor / Collaborator

Chettinad Academy of Research & Education

CTRI/2024/09/073898

/ Not yet recruitingNot ApplicableIIT

Comparison of Two Different Volumes of Fixed Dose of 2 percent Xylocaine for Ultrasound Guided Popliteal Nerve block in Below knee surgeries,a Double Blinded Randomised controlled Study - Nil

Start Date24 Sep 2024

Sponsor / Collaborator

Chettinad Academy of Research & Education

CTRI/2024/02/062242

/ Not yet recruitingPhase 1IIT

COMPARATIVE STUDY OF Intrathecal Isobaric Ropivacaine (0.75%) WithBuprenorphine and Isobaric Ropivacaine (0.75%) With Clonidine inPATIENTS UNDERGOING LOWER LIMB ORTHOPEDIC SURGERIES AND LOWERABDOMINAL SURGERIES UNDER SUBARACHNOID BLOCK: A PROSPECTIVE RANDOMIZED DOUBLE- BLIND STUDY ? - COMPARATIVE STUDY OF INTRATHECAL ISOBARIC ROPIVACAINE (0.75%) with BUPRENORPHINE and ISOBARIC ROPIVACAINE (0.75%) with CLONIDINE In Patients Undergoing Lower Limb and Lower abdominal surgeries UNDER

Start Date12 Feb 2024

Sponsor / Collaborator

Chettinad Academy of Research & Education

100 Clinical Results associated with Chettinad Academy of Research & Education

0 Patents (Medical) associated with Chettinad Academy of Research & Education

1,071

Literatures (Medical) associated with Chettinad Academy of Research & Education

31 Dec 2025·Gut Microbes Reports

Gut microbial metabolites as a convergence point between autoimmunity and solid tumors

Author: Shibi Anilkumar, Anu ; Thomas, Sheena Mariam ; Veerabathiran, Ramakrishnan

The human gut microbiome, a diverse community of trillions of microorganisms, is essential for controlling numerous bodily functions, such as metabolism, immune response, and epithelial barrier integrity.The gut microbiota comprises bacteria, viruses, fungi, and other microorganisms that affect human health, metabolic pathways, and immune responses.Dysbiosis, or the imbalance of gut microbial composition, has been linked to the pathogenesis of several ailments, including cardiovascular conditions, gastrointestinal conditions, allergies, obesity, autoimmune disorders, and tumors.The interaction between gut microbes and immune responses, mainly through Tregs cells and Th17 cells, underscores the microbiome′s function in immune regulation.Furthermore, gut microbial metabolites act as signaling mols. and substrates for metabolic processes, impacting autoimmune disorders and cancer development.Recent research highlights the microbiome′s potential role in cancer immunoediting, where gut microbial metabolites may either promote or suppress cancer progression by modulating inflammation and immunosuppression.This review delves into the critical functions of the gut microbiome, its influence on autoimmune disorders, and the emerging connection between gut microbial metabolites and cancer immunoediting, offering new insights into their impact on human health and disease.

31 Dec 2025·Annals of Medicine

Multiple radiations and its effect on biological system – a review on in vitro and in vivo mechanisms

Review

Author: Agraharam, Gopikrishna ; Girigoswami, Agnishwar ; Balasubramanian, Deepika ; Girigoswami, Koyeli

PURPOSEWe are exposed to different types of radiation from natural sources or for biomedical diagnostic and therapeutic purposes at different doses or times. The dose, duration, and number of exposures can cause multiple effects both in vivo and in vitro. Several researchers have explored the effects of ionizing and non-ionizing radiation in cell lines and animal models. Macromolecules, such as DNA, RNA, and proteins, are the primary targets of damage and can lead to several diseases, including cancer and even cell death. Chronic low-dose exposure of cells to radiation can cause alterations in gene expression and can be deleterious to the fate of the cells. We aim to discuss the implications of multiple radiations on different biological systems, including how nanotechnology can facilitate the effects of radiation in therapeutics.CONCLUSIONIn this review, we discuss the in vitro and in vivo changes that occur due to exposure to different types of radiation used in diagnosis, therapeutics, and other means, such as radiation equipment operators and patients being exposed. The effects of ionizing and non-ionizing radiation have been discussed separately. We have also mentioned in detail about the human-caused accidents of Hiroshima and Chernobyl in this article. The application of nanotechnology in facilitating the effects of radiation in the therapy and management of radioresistance of cells has also been discussed. The radio resistance and method to improve the radiosensitivity have also been mentioned. This review article can reflect the recent developments in the various uses of ionizing and non-ionizing radiation in biomedical field and will open up new avenues to utilize radiation in a more prudent way. The role of nanotechnology in reducing the harmful effects of radiation is also discussed.

31 Dec 2025·Annals of Medicine

MicroRNA-122 overexpression suppresses the colon cancer cell proliferation by downregulating the astrocyte elevated gene-1/metadherin oncoprotein

Article

Author: Banerjee, Antara ; Malayaperumal, Sarubala ; Zhang, Hong ; NR, Rajesh Kanna ; Pathak, Surajit ; Sun, Xiao-Feng ; Mohammed Rafi, Shabana Thabassum ; Jothimani, Ganesan ; Ramachandran, Ilangovan ; Sriramulu, Sushmitha

BACKGROUNDMicroRNAs (miRNAs) are small non-coding RNAs that regulate essential cellular functions, such as cell adhesion, proliferation, migration, invasion, and programmed cell death, and therefore, alterations in miRNAs can contribute to carcinogenesis. Previous studies have shown that miRNA-122 is abundant in the liver and regulates cell proliferation, migration, and apoptosis. However, the expression pattern and mechanism of actions of miR-122 remain primarily unknown in colon cancer.METHODSIn this study, we analyzed The Cancer Genome Atlas Colon Adenocarcinoma (TCGA-COAD) database to assess the clinical significance of astrocyte elevated gene-1 (AEG-1)/metadherin (MTDH) and miR-122 in colon cancer. MiR-122 overexpression studies were performed in HCT116, SW480, and SW620 cell lines. Dual-luciferase assay was carried out to confirm the interaction between AEG-1 and miR-122. In vivo-JetPEI-transfection reagent was used for in-vivo transient transfection of miR-122 in the AOM/DSS-induced colon tumor mouse model.RESULTSOur results demonstrate that miR-122 was downregulated in colon cancer cells, and it influences the expressions of apoptotic factors and inflammatory cytokines. MiR-122 overexpression in HCT116, SW480, and SW620 cells showed upregulation of Caspase 3, Caspase 9, and BAX and decreased expression of BCL2, which are pro-apoptotic and anti-apoptotic members that maintain a ratio between cellular survival and cell death. In vivo transient transfection of miR-122 mimic in AOM/DSS induced colon tumor mouse model showed less inflammation and disease activity. The TCGA-COAD data indicated that AEG-1 expression was higher in patients with low expression of miR-122 and lower AEG-1 expression in patients with higher expression miR-122.CONCLUSIONOur findings highlight the key role of miR-122 in the high grade of colonic inflammation, and possibly in colon cancer, and the use of miR-122 mimic might be a therapeutic option.

100 Deals associated with Chettinad Academy of Research & Education

100 Translational Medicine associated with Chettinad Academy of Research & Education

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