Ningbo Meishu Pharmaceutical Technology Co., Ltd

main purpose: The pioglitazone and metformin tablets produced by Ningbo Meihua Tiankang Pharmaceutical Co., Ltd. entrusted by Ningbo Meisu Pharmaceutical Technology Co., Ltd. were used as the test preparation (specification: 15mg/500mg). According to the relevant regulations of bioequivalence testing, it was compared with Takeda Tuopin Co., Ltd. The company's pioglitazone and metformin tablets (trade name: Mikuto® Formulated Tablets LD, specifications: 15mg/500mg) are used as reference preparations. Bioequivalence tests are conducted to compare the two preparations in single doses under fasting and postprandial conditions. of bioequivalence. Secondary purpose: To evaluate the safety of a single oral dose of the test preparation (Pioglitazone and Metformin Tablets, T) and the reference preparation (Pioglitazone® Tablets LD, R) in healthy Chinese adult subjects.

Primary objective: Using Avatrombopag Maleate Tablets (trade name: Doptelet (Su Kexin), specification: 20mg (calculated as C29H34Cl2N6O3S2) from AkaRx Inc. as the reference preparation and Avatrombopag Maleate Tablets (20mg (calculated as C29H34Cl2N6O3S2) developed by Ningbo Meishu Pharmaceutical Technology Co., Ltd. as the test preparation, a single-center, randomized, open, single-dose, two-preparation, two-sequence, four-period, completely repeated crossover design clinical trial was conducted to evaluate the bioequivalence of the two preparations in fasting and fed states in healthy Chinese subjects. Secondary objective: To observe the safety of the test preparation and the reference preparation in healthy Chinese subjects.

Main objective: To evaluate the bioequivalence of the leprocaine cream produced by Ningbo Meishu Pharmaceutical Technology Co., Ltd. as the test preparation and the leprocaine cream produced by Aspen Pharma Trading Limited as the reference preparation in humans.