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Last update 08 May 2025

Vardhman Mahavir Medical College & Safdarjung Hospital

Hospital|2001|India|

www.vmmc-sjh.nic.in

Hospital|2001|India|

www.vmmc-sjh.nic.in

Last update 08 May 2025

Overview

Pipeline

Deal

Translational Medicine

Overview

193

Clinical Trials associated with Vardhman Mahavir Medical College & Safdarjung Hospital

CTRI/2025/03/082224

/ Not yet recruitingNot ApplicableIIT

Association of serum estradiol and progesterone levels one day prior to frozen embryo transfer with clinical pregnancy outcome - Nil

Start Date24 Mar 2025

Sponsor / Collaborator

Vardhman Mahavir Medical College & Safdarjung Hospital

CTRI/2024/11/076990

/ Not yet recruitingNot ApplicableIIT

A comparison of endotracheal tube cuff pressure changes between supine and prone position in patients undergoing lumbar spine surgery - Nil

Start Date16 Dec 2024

Sponsor / Collaborator

Vardhman Mahavir Medical College & Safdarjung Hospital

CTRI/2024/10/075361

/ Not yet recruitingPhase 2/3IIT

Effect of ketamine treatment on suicidality among severely depressed patients at high risk of suicide - NIL

Start Date30 Oct 2024

Sponsor / Collaborator

Vardhman Mahavir Medical College & Safdarjung Hospital

100 Clinical Results associated with Vardhman Mahavir Medical College & Safdarjung Hospital

0 Patents (Medical) associated with Vardhman Mahavir Medical College & Safdarjung Hospital

2,964

Literatures (Medical) associated with Vardhman Mahavir Medical College & Safdarjung Hospital

01 Jul 2025·Revista Española de Patología

Systematic review and meta-analysis of the Papanicolaou Society of Cytopathology (PSC) system in diagnosing pancreatic lesions: Evaluating diagnostic accuracy

Review

Author: Zaheer, Sufian ; Fattahi-Darghlou, Marzieh ; Ahuja, Sana

INTRODUCTIONThe Papanicolaou system plays a vital role in cytological evaluation, particularly in the diagnosis of pancreatic lesions. However, there is a lack of comprehensive evaluation regarding its diagnostic accuracy in pancreatic fine needle aspirations (FNAs). This study seeks to address this gap by conducting a systematic review and meta-analysis to assess the diagnostic accuracy of the Papanicolaou Society of Cytopathology (PSC) system in diagnosing pancreatic lesions.METHODSA systematic search of PubMed and EMBASE databases was conducted up to March 20, 2024, using predefined search terms related to pancreas, fine needle aspiration biopsy (FNAB), and diagnostic accuracy. The selected articles were assessed for risk of bias using the QUADAS-2 tool. A meta-analysis for sensitivity and specificity for each cut-off - namely, "Atypical considered positive", "Neoplastic considered positive", "Suspicious of Malignancy considered positive," and "Malignant considered positive" - was performed after excluding inadequate samples in each study. To assess diagnostic accuracy, summary receiver operating characteristic (sROC) curves were constructed, and the diagnostic odds ratio (DOR) was pooled.RESULTSTwelve studies met the inclusion criteria, comprising a total of 3604 cases. Sensitivity and specificity varied across the PSC categories, with the "Malignant" category showing the highest sensitivity (70%) and specificity (99%). The "Suspicious for malignancy and higher risk categories" demonstrated high sensitivity (81%) and specificity (97%).CONCLUSIONThis meta-analysis underscores the accuracy of the PSC system in reporting pancreatic aspirates. It highlights the significance of the "Suspicious" and "Malignant" categories in diagnosing malignancy, as well as the "Benign" and "Atypical" categories in ruling out malignancy.

01 Jul 2025·Revista Española de Patología

Bilateral primary ovarian clear cell carcinoma in a multiparous perimenopausal woman

Article

Author: Aziz Khan, Adil ; Nagar, Neeti ; Ahluwalia, Charanjeet ; Ahuja, Sana

Primary ovarian clear cell carcinoma (OCCC) is a rare subtype of epithelial ovarian carcinoma (EOC), accounting for 5-10% of EOCs in the U.S., with a higher prevalence in East Asia. It is characterized by clear cells forming solid, tubular, or papillary patterns, and presents diagnostic challenges due to its resemblance to renal clear cell carcinomas. Typically affecting nulliparous postmenopausal women, OCCC is associated with high recurrence rates and low sensitivity to platinum-based chemotherapy. We report a case of bilateral primary OCCC in a 45-year-old multiparous woman with no history of endometriosis. She presented with lower abdominal pain and swelling persisting for 7-8 months. Imaging revealed a large, heterogeneous abdominopelvic mass. Surgery included total abdominal hysterectomy with bilateral salpingo-oophorectomy. Histopathological and immunohistochemical analyses confirmed bilateral OCCC, with positive staining for AMACR, Napsin A, and PAX8, and negative results for WT1, ER, and PR. This case highlights the importance of thorough diagnostic evaluation in atypical presentations. The postoperative course was uneventful, and she subsequently received adjuvant therapy.

04 May 2025·Expert Review of Endocrinology & Metabolism

Diabetes mellitus and HbA1c as predictors of mortality in hospitalized COVID-19 patients

Article

Author: Balakrishnan, Ira ; Bansal, Sandeep ; Gupta, Praveen ; Gupta, Anunay

BACKGROUNDThe role of diabetes mellitus (DM) in hospitalized COVID-19 patients and of HbA1c in hospitalized COVID-19 patients with DM were not studied adequately in the past.RESEARCH DESIGN AND METHODSIt was a retrospective cohort study. In this study, data from 305 hospitalized COVID-19 patients was analyzed. The study objective was to determine the association of DM with in-hospital mortality in COVID-19 patients. Another study objective was to determine the association of HbA1c with mortality in COVID-19 patients with DM.RESULTSIn this retrospective study, DM was present in 41.3% (126/305) of the study population. The multivariate Cox regression analysis showed a significant association between DM and mortality (adjusted hazard ratio (aHR): 2.116, 95% CI: 1.088-4.116, p = 0.027). The median HbA1c in diabetic patients was 8.9% (7.5-11.0). HbA1c was found to be associated with mortality in diabetic patients in the multivariate cox-regression analysis (aHR:1.272, 95% CI: 1.028-1.574, p = 0.027). The multivariate Cox regression analysis also showed the association of HbA1c (10.5%≤HbA1c > 10.5%) as a dichotomous variable with in-hospital mortality (aHR: 2.53, 95% CI: 2.606-194.81, p = 0.005) in diabetic patients.CONCLUSIONSDM was independently associated with mortality in hospitalized COVID-19 patients in the multivariate analysis. In COVID-19 patients with DM, HbA1c was associated with mortality as a continuous and dichotomous variable in the multivariate analysis.

100 Deals associated with Vardhman Mahavir Medical College & Safdarjung Hospital

100 Translational Medicine associated with Vardhman Mahavir Medical College & Safdarjung Hospital

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Vardhman Mahavir Medical College & Safdarjung Hospital

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Pipeline Snapshot as of 07 Jun 2025

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