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Respiratory Diseases

Neoplasms

Small molecule drug

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Most used technologies in drug development

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Disease Domain	Count

Neoplasms	1

Top 5 Drug Type	Count

Small molecule drug	1

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PDHK1 x PKM2	1

AbstractThe Janus fabrics designed for personal moisture/thermal regulation have garnered significant attention for their potential to enhance human comfort. However, the development of smart and dynamic fabrics capable of managing personal moisture/thermal comfort in response to changing external environments remains a challenge. Herein, a smart cellulose-based Janus fabric was designed to dynamically manage personal moisture/heat. The cotton fabric was grafted with N-isopropylacrylamide to construct a temperature-stimulated transport channel. Subsequently, hydrophobic ethyl cellulose and hydrophilic cellulose nanofiber were sprayed on the bottom and top sides of the fabric to obtain wettability gradient. The fabric exhibits anti-gravity directional liquid transportation from hydrophobic side to hydrophilic side, and can dynamically and continuously control the transportation time in a wide range of 3–66 s as the temperature increases from 10 to 40 °C. This smart fabric can quickly dissipate heat at high temperatures, while at low temperatures, it can slow down the heat dissipation rate and prevent the human from becoming too cold. In addition, the fabric has UV shielding and photodynamic antibacterial properties through depositing graphitic carbon nitride nanosheets on the hydrophilic side. This smart fabric offers an innovative approach to maximizing personal comfort in environments with significant temperature variations.

01 Dec 2025·Nano-Micro Letters

Advanced Functional Electromagnetic Shielding Materials: A Review Based on Micro-Nano Structure Interface Control of Biomass Cell Walls

Review

Author: Huang, Runzhou ; Luo, Jing ; Hou, Hua ; Shi, Yang ; Guo, Zhanhu ; Li, Jianzhang ; Jiang, Jinxuan ; Xu, Kaimeng ; Wu, Mingjun ; Jia, Chong ; El-Bahy, Zeinhom M ; Asiri, Yazeed M ; Ge, Shengbo ; Amin, Mohammed A ; Chen, Xiangmeng ; Qiu, Hua ; Alshammari, Anoud Saud

AbstractResearch efforts on electromagnetic interference (EMI) shielding materials have begun to converge on green and sustainable biomass materials. These materials offer numerous advantages such as being lightweight, porous, and hierarchical. Due to their porous nature, interfacial compatibility, and electrical conductivity, biomass materials hold significant potential as EMI shielding materials. Despite concerted efforts on the EMI shielding of biomass materials have been reported, this research area is still relatively new compared to traditional EMI shielding materials. In particular, a more comprehensive study and summary of the factors influencing biomass EMI shielding materials including the pore structure adjustment, preparation process, and micro-control would be valuable. The preparation methods and characteristics of wood, bamboo, cellulose and lignin in EMI shielding field are critically discussed in this paper, and similar biomass EMI materials are summarized and analyzed. The composite methods and fillers of various biomass materials were reviewed. this paper also highlights the mechanism of EMI shielding as well as existing prospects and challenges for development trends in this field.

01 Feb 2025·Separation and Purification Technology

Based on size-exclusion effect of selective removal of organic pollutants in complex water quality by low temperature plasma: Degradation behavior and selective mechanism analysis

Author: Wei, Wenxian ; Wang, Xinhao ; Tian, Tian ; Li, Wenhui ; Chen, Zhonglin ; Gu, Cheng ; Qiao, Weichuan ; Xia, Ying ; Zhang, Ming ; Liu, Chenyong

The presence of natural organic matters (NOMs) will have a neg. effect on the removal of small mol. organic contaminants in complex water quality, therefore, it′s very important to design a catalyst with size-exclusion function to achieve the selective removal of targeted pollutant.Herein, a novel ZIF-L catalyst precursor with lamellar stack structure is designed, and iron as heteroatom is doped in ZIF-L gaps named ZIF-L@Fe.After pyrolysis, Fe ions are transformed into Fe nanoparticles, and act as the active sites of catalyst.In order to verify the selective removal ability of resulted NSC@Fe in dielec. barrier discharge (DBD), tetracycline hydrochloride (TTCH) and humic acid (HA) is selected as the target pollutant and coexistence macromol. interferent, resp.In the presence of HA (50 mg/L), the degradation rate of TTCH in the system is not significantly affected (with HA, k = 0.037 min^-1; without HA, k 0.036 min^-1), which is mainly due to the layered material stacking characteristics (size-exclusion).The degradation mechanism and pathway are further confirmed by radical quenching experiments and liquid chromatog.-mass spectrograph (LC-MS), resp.This study is believed to shed new light on how to rationally design catalyst with selective removal of organic pollutants in complex water quality for water remediation.

100 Deals associated with Nanjing Forestry University

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100 Translational Medicine associated with Nanjing Forestry University

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Pipeline

Pipeline Snapshot as of 23 Dec 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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