[Translation] A Phase I clinical study to evaluate the safety, tolerability, pharmacokinetic characteristics and preliminary efficacy of JL1132 in the treatment of relapsed/refractory hematological malignancies
主要目的:评价JL1132治疗复发/难治性血液肿瘤的耐受性和安全性,探索最大耐受剂量(MTD),以及II期临床推荐剂量(RP2D)。
次要目的:评价JL1132在复发/难治性血液肿瘤患者的药代动力学(PK)特征及药效学(PD)特征;评价JL1132治疗复发/难治性血液肿瘤的有效性。
[Translation] Primary objective: To evaluate the tolerability and safety of JL1132 in the treatment of relapsed/refractory hematological malignancies, and to explore the maximum tolerated dose (MTD) and the recommended dose (RP2D) for Phase II clinical trials.
Secondary objective: To evaluate the pharmacokinetic (PK) and pharmacodynamic (PD) characteristics of JL1132 in patients with relapsed/refractory hematological malignancies; to evaluate the effectiveness of JL1132 in the treatment of relapsed/refractory hematological malignancies.