Delving into the Latest Updates on CSL Behring (Australia) Pty Ltd. with Synapse

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Other Diseases

Congenital Disorders

Hemic and Lymphatic Diseases

Immunoglobulin

AAV based gene therapy

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Disease Domain	Count

Hemic and Lymphatic Diseases	1
Infectious Diseases	1

Top 5 Drug Type	Count

Immunoglobulin	1
AAV based gene therapy	1

Top 5 Target	Count

Tetanus toxin	1
factor IX(Coagulation factor IX)	1

The enzyme-linked immunosorbent assay (ELISA) is extensively used for measurement of proteins utilized for various research and diagnostic purposes in the biological disciplines. However, it is a labor-intensive and lengthy procedure due to a number of incubation and washing steps required for performing the assay. The ELISA procedure in the current study has been simplified through the simultaneous addition of antigen and detection antibody and elimination of washing steps. This resulted in a decreased time required to perform the procedure and without affecting assay capability. This approach offers the possibility of increasing ELISA productivity in low throughput laboratories without the need for alternative analytical platforms which would require significant assay redevelopment and capital expense.

03 Aug 2017·Human Vaccines & ImmunotherapeuticsQ3 · MEDICINE

Rubella antibodies in Australian immunoglobulin products

Q3 · MEDICINE

Article

Author: Bertolini, Joseph ; Young, Megan K. ; Kotharu, Pushpa ; Maher, Darryl ; Cripps, Allan W.

Rubella antibodies are not routinely measured in immunoglobulin products and there is a lack of information on the titer in Australian products. To facilitate future studies of the effectiveness of passive immunisation for preventing rubella and congenital rubella syndrome, this study measured the concentration of rubella-specific antibodies in Australian intramuscular (IM) and intravenous (IV) human immunoglobulin products suitable for post-exposure prophylaxis using a chemiluminescent immunoassay. The GMT ± GSD for the IM product was 19 ± 1.2 IU/mg (2980 ± 1.2 IU/mL). The GMT ± GSD for the IV product was 12 ± 1.5 IU/mg (729 ± 1.5 IU/mL). At present, Australian guidelines recommend offering non-immune pregnant women exposed to rubella 20 mL of intramuscular immunoglobulin within 72 hours of exposure. This equates to 42,160 IU of rubella antibodies if the lowest titer obtained for the Australian IM product is considered. The same dose would be delivered by 176 mL of the Australian IV product at the lowest measured rubella-specific antibody titer.

04 Mar 2017·Human Vaccines & ImmunotherapeuticsQ3 · MEDICINE

Do Australian immunoglobulin products meet international measles antibody titer standards?

Q3 · MEDICINE

Article

Author: Bertolini, Joseph ; Young, Megan K. ; Kotharu, Pushpa ; Maher, Darryl ; Cripps, Allan W.

The effectiveness of passive immunisation post-exposure to measles appears subject to a dose-response effect. New Zealand and the United Kingdom have increased the recommended dose of polyclonal human immunoglobulin for post-exposure prophylaxis within the last decade in response to concerns about decreasing levels of measles antibodies in these products. This study used the plaque-reduction neutralization test (PRNT) to measure the titer of measles-specific antibodies in Australian immunoglobulin products for post-exposure prophylaxis and compared the utility of an enzyme-linked immunosorbent assay (ELISA) to the PRNT in available Australian and international samples: Australian intramuscular (n = 10), Australian intravenous (n = 28), New Zealand intramuscular (n = 2), Hizentra (subcutaneous)(USA) (n = 3), and Privigen (intravenous)(USA) (n = 2). Measles titres in Australian IM and IV immunoglobulins ranged from 51 to 76 IU/mL and 6 to 24 IU/mL respectively, as measured by PRNT calibrated to the WHO 3^rd international standard. ELISA titres were variable but higher than PRNT titres in all tested samples. Measles antibody titres in Australian immunoglobulin products meet consensus-prescribed international thresholds. Development of a convenient, standardized, readily accessible assay for determination of measles titres in immunoglobulin products would be useful for future studies and facilitate international comparisons.

100 Deals associated with CSL Behring (Australia) Pty Ltd.

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100 Translational Medicine associated with CSL Behring (Australia) Pty Ltd.

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Pipeline

Pipeline Snapshot as of 23 Dec 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Approved

2

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Etranacogene dezaparvovec ( factor IX )	Hemophilia B More	Approved
Human anti-tetanus immunoglobulin(CSL Behring LLC) ( Tetanus toxin )	Tetanus More	Approved