Sichuan Xinsidun Pharmaceutial Co., Ltd.

Main research objectives: To investigate the relative bioavailability of a single (fasting/postprandial) oral administration of 2.5 mg of the test preparation levamlodipine besylate tablets (specification: 2.5 mg/tablet, calculated as levamlodipine; produced by Sichuan Xinston Pharmaceutical Co., Ltd.) and 5 mg of the reference preparation levamlodipine besylate tablets (trade name: Norvasc®; specification: 5 mg/tablet, calculated as amlodipine; produced by Pfizer Pharmaceuticals Co., Ltd.) in healthy Chinese subjects, analyze the pharmacokinetic parameters of the two preparations, evaluate the bioequivalence of the two preparations, and provide a reference basis for the application and clinical use of the drug. Secondary research objectives: To evaluate the safety of a single (fasting/postprandial) oral administration of 2.5 mg of the test preparation levamlodipine besylate tablets and 5 mg of the reference preparation levamlodipine besylate tablets in healthy Chinese adult subjects.

Main purpose: This study uses the arginine ibuprofen granules (specification: 0.4g (in terms of ibuprofen)) certified by Sichuan Xinston Pharmaceutical Co., Ltd. as the test preparation and the arginine ibuprofen granules (trade name: Sparta, specification: 0.4g (in terms of ibuprofen)) certified by Hainan Zanbang Pharmaceutical Co., Ltd. as the reference preparation to conduct a human bioequivalence test under fasting/postprandial conditions to evaluate the bioequivalence of the test preparation and the reference preparation in healthy subjects. Secondary purpose: Observe the safety of the test preparation and the reference preparation in healthy subjects.

Primary purpose: Using febuxostat tablets (specification: 40 mg) of Sichuan Xinston Pharmaceutical Co., Ltd. as the test preparation and febuxostat tablets (trade name: Feburic, specification: 40 mg) of Teijin Pharma Limited as the reference preparation, according to the relevant provisions of bioequivalence test, the bioequivalence of the two preparations in healthy humans was investigated. Secondary purpose: To observe the safety of the test preparation and the reference preparation in healthy humans.