Help Therapeutics Ltd.

WASHINGTON, Dec. 26, 2025 /PRNewswire/ -- Over the past decade, China has evolved from a biotechnology follower into an increasingly influential global innovator. Once reliant on Western pharmaceutical companies for advanced therapies, the country is now building a homegrown biotech ecosystem that addresses domestic healthcare needs while contributing to global drug development. Continue Reading Eugene Jiaxian Wang, HELP Therapeutics Founder & CEO This shift is driven by sustained policy support, rising R&D investment, and a strong life sciences talent base. China's R&D spending has grown from below 1% of GDP two decades ago to nearly 2.7% in 2023, approaching U.S. levels. With the world's largest cohort of STEM graduates and a rapidly expanding clinical trial infrastructure, China has surpassed the United States in total clinical trials, reinforcing its role in global biomedical research. China's growing international presence is increasingly visible on leading scientific stages. HELP Therapeutics on the Global Stage At the 22nd Global Cardiovascular Clinical Trialists Forum (CVCT), a leading platform for cardiovascular research, Dr. Eugene Jiaxian Wang, Founder and CEO of HELP Therapeutics, presented China's latest clinical progress in cell therapy for heart failure. During the session "Cell Therapy Heart Failure Trials: Cells, Delivery, and Disease-Specific Strategies," Dr. Wang shared translational and clinical data from iPSC-derived cardiomyocyte programs, highlighting China's advancement of cell therapies into rigorously designed, multinational clinical development. HELP's lead program, HiCM-188, is the world's first iPSC-derived regenerative therapy for advanced heart failure to receive IND clearance in both China and the United States. The therapy is currently in Phase II trials in China and Phase I/II trials across the U.S., Singapore, and Thailand, supported by more than six years of follow-up demonstrating robust safety and encouraging efficacy. HELP has also entered a strategic co-development and commercialization partnership with China Resources Sanjiu Pharmaceutical to accelerate clinical translation. From Participants to Leaders China's biotech momentum reflects structural advantages including large patient populations, integrated clinical infrastructure, sustained capital support, and cost-efficient R&D capabilities. These strengths have driven growth in cross-border licensing, with Chinese-origin molecules now accounting for nearly 30% of global drug development. As global healthcare systems confront aging populations and chronic disease, China's biotechnology sector is becoming an indispensable contributor to global innovation. About HELP Therapeutics Help Therapeutics is a pioneering biotechnology company dedicated to revolutionizing the treatment of degenerative diseases through stem cell and regenerative medicine technologies. Media Contact: Mengying Tan +86 13261002597 [email protected] SOURCE HELP Therapeutics 21% more press release views with Request a Demo

NANJING, China I June 16, 2025 I HELP Therapeutics, a global leader in regenerative medicine, and China Resources Sanjiu Pharmaceutical Company, one of China’s largest pharmaceutical companies, have announced a strategic partnership to co-develop and commercialize the investigational cell therapy HiCM-188 in Mainland China. HiCM-188 is the world’s first iPSC-derived regenerative therapy for advanced heart failure to receive IND clearance in both China and the United States. The candidate is currently in Phase II clinical trials in China and Phase I/II trials in the U.S., Singapore, and Thailand. HiCM-188 has shown robust safety and efficacy across more than five years of long-term follow-up. Heart failure remains a major unmet medical need, with its prevalence increasing at double-digit rates along with population ages. Heart transplantation remains the last resort for advanced heart failure patients, but donor deficiency limits clinical application. HiCM-188 presents a promising alternative and could be a potential game changer for this unmet medical need. “This co-development agreement with China Resources Sanjiu marks a significant milestone for HELP Therapeutics,” said Dr. Eugene Wang, Founder and CEO of HELP Therapeutics. “Their exceptional clinical network, innovation mindset, and commercial capabilities will accelerate the availability of our therapies to patients and contribute to the growth of China’s cell therapy industry.” “Cell therapy represents the future of life sciences, offering immense clinical potential for aging-related and refractory diseases,” remarked Mr. Qiu Huawei, Chairman of China Resources Sanjiu. “Our partnership with HELP Therapeutics strengthens our commitment to cell therapy innovation. HELP’s globally leading iPSC platform and defined clinical pipeline make them an ideal partner. Together, we aim to bring new hope to heart failure patients.” Professor Junbo Ge, Academician of the Chinese Academy of Sciences, lauded the collaboration as a milestone in China’s Cell and Gene Therapy (CGT) landscape. He noted that HELP Therapeutics’ focus on heart failure addresses a critical clinical need and bridges the gap between heart transplantation and targeted myocardial repair. “This partnership has the potential to reshape treatment paradigms for patients worldwide,” he said. About HELP Therapeutics HELP Therapeutics is a global leader in regenerative medicine, focused on developing innovative therapies for heart failure and other serious conditions. Leveraging a cutting-edge iPSC platform and a robust clinical pipeline, HELP is dedicated to transforming patient outcomes through advanced cell therapies. SOURCE: HELP THERAPEUTICS

NANJING, China, June 16, 2025 /PRNewswire/ -- HELP Therapeutics, a global leader in regenerative medicine, and China Resources Sanjiu Pharmaceutical Company, one of China's largest pharmaceutical companies, have announced a strategic partnership to co-develop and commercialize the investigational cell therapy HiCM-188. Heart failure remains a major unmet medical need, with its prevalence increasing at double-digit rates. In China alone, an estimated 12 million adults suffer from heart failure, with 2.97 million new cases each year. The five-year survival rate is comparable to that of many malignant tumors. For end-stage patients, heart transplantation is the only proven treatment—but fewer than one in 1,000 patients receive a matching donor heart in time. Cell therapy presents a promising alternative and could transform care for this growing patient population. HiCM-188 is the world's first iPSC-derived regenerative therapy for heart failure to receive IND clearance in both China and the United States. The candidate is currently in Phase II clinical trials in China and Phase I/II trials in the U.S., Singapore, and Thailand. HiCM-188 has shown robust safety and efficacy across more than five years of long-term follow-up. "This co-development agreement with China Resources Sanjiu marks a significant milestone for HELP Therapeutics," said Dr. Wang Jiaxian, Founder and CEO of HELP Therapeutics. "Their exceptional clinical network, innovation mindset, and commercial capabilities will accelerate the availability of our therapies to patients and contribute to the growth of China's cell therapy industry." "Cell therapy represents the future of life sciences, offering immense clinical potential for aging-related and refractory diseases," remarked Mr. Qiu Huawei, Chairman of China Resources Sanjiu. "Through our subsidiary, Tasly Pharmaceuticals, we have already advanced into the MSC cell therapy space. Our partnership with HELP Therapeutics further strengthens our commitment to cell therapy innovation. HELP's globally leading iPSC platform and defined clinical pipeline make them an ideal partner. Together, we aim to bring new hope to heart failure patients." Professor Junbo Ge, Academician of the Chinese Academy of Sciences, lauded the collaboration as a milestone in China's Cell and Gene Therapy (CGT) landscape. He noted that HELP Therapeutics' focus on heart failure addresses a critical clinical need and bridges the gap between heart transplantation and targeted myocardial repair. "This partnership has the potential to reshape treatment paradigms for patients worldwide," he said. About HELP Therapeutics HELP Therapeutics is a global leader in regenerative medicine, focused on developing innovative therapies for heart failure and other serious conditions. Leveraging a cutting-edge iPSC platform and a robust clinical pipeline, HELP is dedicated to transforming patient outcomes through advanced cell therapies. SOURCE HELP THERAPEUTICS WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED