Delving into the Latest Updates on Mycologics, Inc. with Synapse

Overview

ABSTRACTLeishmania major is an important trypanosomatid pathogen that causes leishmaniasis, which is a serious disease in much of the Old World. Current treatments include a small number of antimony compounds that, while somewhat effective, are limited by serious side effects. We have screened a small portion of a unique chemical library and have found at least three novel compounds that are effective against L. tarentolae and L. major in vitro and in a murine macrophage model of L. major infection. These compounds were effective in both assays at doses significantly lower than those of sodium stibogluconate (Pentostam) and represent possible candidates for drug development.

01 Feb 2003·Current opinion in investigational drugs (London, England : 2000)

New cell wall targets for antifungal drugs.

Review

Author: Nakata, Mitsunori ; Selitrennikoff, Claude P

Fungal infections in humans caused by filamentous moulds and yeasts continue to be serious and often life-threatening, especially among immunocompromised patients. One of the most immediate and unmet medical needs is the identification of new treatment options for invasive aspergillosis infection. The fungal cell wall, as the most obvious difference between human and fungal cells, represents an excellent target for antifungals. Cell wall carbohydrates are polymerized from uridine di-phospho sugars that are synthesized by several biochemical pathways. The pathways for the synthesis of these cell wall precursors represent unexplored targets for new antifungals that have modes of action that are different from currently used therapeutics. This review will focus on the identification of several new therapy targets and on assays to screen for inhibitors of enzymes critical to the synthesis of cell wall precursors.

Current Opinion in Anti-Infective Investigational Drugs

Zeamatin, an antifungal protein

Author: Stevens, David A. ; Wilson, Shelly J. ; Selitrennikoff, Claude P. ; Clemons, Karl V.

A review with 41 referencesCertain plant defense proteins have potent antifungal activity in vitro and may be useful as therapeutic agents in the treatment of human fungal disease.Pathogenesis-related Group 5 proteins are homologous to thaumatin, a sweet tasting protein from a South African shrub, and are known as thaumatin-like proteins.Thaumatin-like proteins have been isolated from a number of monocots and dicots; included is zeamatin, a protein isolated from Zea mays.Zeamatin appears to exert its antifungal activity by a mechanism of action significantly different from that of currently-used antifungal therapeutics.In addition, recent results obtained by the authors of this review indicate that zeamatin is effective in combination with other antifungal drugs in treating systemic and vaginal Candida albicans infections.

100 Deals associated with Mycologics, Inc.

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100 Translational Medicine associated with Mycologics, Inc.

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Pipeline

Pipeline Snapshot as of 07 Mar 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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