A review with references Despite many advances in antihypertensive treatment, blood pressure control remains far from perfect in clin. practice. The use of fixed low-dose combination therapy appears a novel strategy in the first-line management of mild to moderate hypertension but, in the light of the history of antihypertensive treatment, it is a logical development on the path to improved blood pressure control. Further studies are needed to ensure that these combinations not only control blood pressure but also have pos. target organ effects, decrease morbidity and mortality, and increase compliance. However, according to the latest international guidelines. they can already be considered effective and safe in the first-line therapy of essential hypertension and isolated systolic hypertension in adults and the elderly. Fixed low-dose combination therapy may have the potential to improve hypertension control in the overall population and prevent the associated cardiovascular complications.