Powders are commonly used dosage forms for drug delivery through nasal, pulmonary, and oral routes. Recently, bioactive wound powders (BWPs) have attracted considerable attention as wound dressings and drug delivery systems because of their features like high stability, rapid effect, applicability on deep or irregular-shaped wounds, exudate absorption, in-situ hydrogel formation, and no need for dressing change. Medicinal plants, drugs, and animal-derived compounds such as proteins and extra cellular matrixes can be formulated to BWPs. Furthermore, various biopolymers can be used to formulate BWPs with desired properties. The increasing number of clin. trials, patents, and marketed products necessitate a review about BWPs. The current review outlines design aspects of BWPs including composition, flowability, fluid uptake, in-situ hydrogel formation, adhesion to wound, and interaction of particles with wound environment, as well as their fabricating techniques, sterilization method, and packaging. Moreover, we highlight commercialized products, ongoing clin. trials, and patents.