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Overview

PRIMARY: To assess the safety of nimodipine in the treatment of HIV-Associated Motor / Cognitive Complex (formerly AIDS dementia complex). To assess the systemic or central nervous system toxicities (e.g., rash, headache, gastrointestinal symptoms, nausea, dyspnea, muscle pain or cramp, acne) of nimodipine.
SECONDARY: To assess the efficacy of nimodipine in stabilizing the progression of HIV-Associated Motor / Cognitive Complex by improvement in neuropsychological test performance, peripheral neuropathy, or other neurologic manifestations.
HIV-infected patients may develop a condition known as HIV-Associated Motor / Cognitive Complex (also known as AIDS dementia complex) that causes damage to the nervous system, particularly the brain and spinal cord. Evidence exists that nimodipine protects nerve cells in culture from injury by HIV. Although nimodipine has been used in patients with other neurological problems, its safety and effectiveness in halting the progression of HIV-Associated Motor / Cognitive Complex is not yet known.

Start Date-

Sponsor / Collaborator

National Institute of Allergy & Infectious Diseases

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100 Clinical Results associated with Miles Laboratories, Inc.

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0 Patents (Medical) associated with Miles Laboratories, Inc.

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286

Literatures (Medical) associated with Miles Laboratories, Inc.

01 Jan 1989·Biological Chemistry Hoppe-Seyler

A Redetermination of the Concentration of α2-Macroglobulin in Human Plasma

Article

Author: Roberts, Ronald C. ; Coan, Michael H.

The concentration of alpha 2-macroglobulin in human plasma has been remeasured utilizing a carefully isolated and characterized sample of alpha 2-macroglobulin as a standard. A highly purified sample of alpha 2-macroglobulin with a total trypsin binding capacity of 1.7 mol trypsin/mol alpha 2-macroglobulin was used as a standard for both a radial immunodiffusion and a rocket immunoelectrophoresis technique. With this preparation as a standard, the concentration of alpha 2-macroglobulin in a normal plasma pool over 10,000 donors was found to be about 1.2 mg/ml. A similar concentration (1.3 mg/ml) was found when using a functional trypsin binding assay. This concentration is considerably less than the usually accepted mean of the normal range for alpha 2-macroglobulin.

01 Jun 1988·Therapeutic Drug MonitoringQ3 · MEDICINE

Dry Reagent Immunoassay for Measuring Phenobarbital in Serum and Plasma

Q3 · MEDICINE

Article

Author: Greenquist, Alfred ; Sommer, Ronald ; Thompson, Stephan ; Clayborn, Joan

A reagent strip has been developed for measuring phenobarbital concentrations in serum or plasma. This strip utilizes the apoenzyme reactivation immunoassay system (ARIS) and is designed for use with the Ames Seralyzer reflectance photometer. The test takes 85 s and compares strip reactivities with a two-point calibration line that is stored in the instrument. Within-run precision coefficient of variation ranges from 2.4 to 4.1% over five concentrations while the between-run precision ranges from 2.3 to 4.9%. Results obtained with clinical serum samples correlated well (r greater than 0.99) with those obtained by a fluorescence polarization immunoassay (TDx). The strips crossreact with other barbituric acid derivatives that are not coadministered with phenobarbital. Crossreactivity to the metabolite p-hydroxyphenobarbital is sufficiently low as to not interfere in the usual specimens. Samples that are hemolyzed, highly icteric, or from uremic patients should be avoided. This assay is a rapid and convenient method for monitoring serum or plasma phenobarbital concentrations. It is particularly well suited for decentralized test sites, such as emergency rooms, urgent care centers, and physician's offices.

04 Mar 1988·TransfusionQ3 · MEDICINE

Five‐week red cell storage with preservation of 2,3 DPG

Q3 · MEDICINE

Article

Author: Myhre, Byron A. ; Carmen, Raleigh A. ; Simon, Toby L. ; Marcus, Carol S. ; Moroff, Gary ; Nelson, Edward J. ; Moore, Gerald L. ; Sohmer, Paul R. ; Leng, Barry S.

The 2,3 diphosphoglycerate (2,3 DPG) content of red cells stored in current anticoagulant‐preservative products decreases rapidly after the first few days of storage, and by 3 weeks the red cells are essentially depleted of 2,3 DPG. Because ascorbic acid and ascorbate‐2‐phosphate (A‐ 2‐P) are effective in maintaining erythrocyte 2,3 DPG during liquid preservation, ascorbate was stabilized through autoclaving and subsequent storage by adding it as the trisodium salt of A‐2‐P to a phosphate‐adenine‐saline solution at a pH of 8.5 to 9.0. Red cell concentrates prepared from blood drawn into citrate‐phosphate‐double‐ dextrose were supplemented with the A‐2‐P additive solution (AS‐4) and studied in vitro and in vivo. Mean 2,3 DPG values for 22 units were 147.6, 113.5, and 82.3 percent of initial value after storage for 3, 4, and 5 weeks, respectively. Maintenance of 2,3 DPG was at the expense of adenosine triphosphate (ATP), which fell to as low as 22.2 percent of initial value after 5 weeks. Despite the low ATP values, the 24 hour 51Cr‐labeled red cell recoveries averaged 80.8 and 74.1 percent after 4 and 5 weeks of storage, respectively. The AS‐4 system provides a red cell product with acceptable viability and improved oxygen off‐loading function.

100 Deals associated with Miles Laboratories, Inc.

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100 Translational Medicine associated with Miles Laboratories, Inc.

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Pipeline

Pipeline Snapshot as of 31 Jan 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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