Delving into the Latest Updates on Miles Laboratories, Inc. with Synapse

Overview

PRIMARY: To assess the safety of nimodipine in the treatment of HIV-Associated Motor / Cognitive Complex (formerly AIDS dementia complex). To assess the systemic or central nervous system toxicities (e.g., rash, headache, gastrointestinal symptoms, nausea, dyspnea, muscle pain or cramp, acne) of nimodipine.
SECONDARY: To assess the efficacy of nimodipine in stabilizing the progression of HIV-Associated Motor / Cognitive Complex by improvement in neuropsychological test performance, peripheral neuropathy, or other neurologic manifestations.
HIV-infected patients may develop a condition known as HIV-Associated Motor / Cognitive Complex (also known as AIDS dementia complex) that causes damage to the nervous system, particularly the brain and spinal cord. Evidence exists that nimodipine protects nerve cells in culture from injury by HIV. Although nimodipine has been used in patients with other neurological problems, its safety and effectiveness in halting the progression of HIV-Associated Motor / Cognitive Complex is not yet known.

Start Date-

Sponsor / Collaborator

National Institute of Allergy & Infectious Diseases

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100 Clinical Results associated with Miles Laboratories, Inc.

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0 Patents (Medical) associated with Miles Laboratories, Inc.

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274

Literatures (Medical) associated with Miles Laboratories, Inc.

12 Apr 2011·Journal of Pharmacy and PharmacologyQ3 · MEDICINE

Effect of paracetamol coadministration on aspirin-induced gastrointestinal bleeding in dogs

Q3 · MEDICINE

Article

Author: Helms, R J ; Johnson, N ; Leeling, J L

Gastrointestinal microbleeding induced by aspirin [50-78-2] (62.5 mg/kg twice daily by gavage) was unaffected by coadministration of paracetamol [103-90-2] and aspirin at the same dosage.Daily fecal blood loss in dogs treated with paracetamol, aspirin, and paracetamol-aspirin were 0.40, 4.81, and 5.46 mL, resp.Paracetamol-aspirin combinations for human use may not provide, therefore, any advantage over aspirin alone.

12 Apr 2011·Journal of Pharmacy and PharmacologyQ3 · MEDICINE

In vitro assessment of anti-inflammatory activity

Q3 · MEDICINE

Article

Author: Kurchacova, Elva ; Sancilio, Lawrence F ; Phillips, Barrie M

Of 57 diverse organic acids screened for antiinflammatory activity in vitro 42 gave results equivalent to or greater than acetylsalicylic acid in the trinitrobenzaldehyde assay.In most instances comparable activity could not be demonstrated in vivo using the carrageenan foot edema method or the azovan blue-carrageenan pleural effusion method.α-5-Diphenyl-2H-tetrazole-2-acetic acid, m-[(α-phenylphenacyl)amino]benzoic acid, m-[3-(2,4-dioxo-1H,3H-quinazolinyl)]benzoic acid, 5,5'-selenobis salicylic acid, 3-octylsalicylic acid, N-acetyl-p-aminophenol are representative of the 42 acids with in vitro antiinflammatory effects.

12 Apr 2011·Journal of Pharmacy and PharmacologyQ3 · MEDICINE

Influence of L-glutamine on aspirin-induced gastrointestinal microbleeding in dogs

Q3 · MEDICINE

Article

Author: Helms, R J ; Johnson, N ; Leeling, J L

Coadministration of L-glutamine [56-85-9] (264, 528, or 1056 mg, orally) with aspirin [50-78-2] (650 mg) did not alter the degree of aspirin-induced gastrointestinal microbleeding in beagles.

100 Deals associated with Miles Laboratories, Inc.

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100 Translational Medicine associated with Miles Laboratories, Inc.

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Pipeline

Pipeline Snapshot as of 26 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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