Last update 04 Nov 2024

Nimodipine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-methoxyethyl ester 5-isopropyl ester, isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate, isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
+ [33]
Target
Mechanism
Cav2.1 inhibitors(calcium voltage-gated channel subunit alpha1 A inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (US), Fast Track (US), Orphan Drug (EU)
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Structure

Molecular FormulaC21H26N2O7
InChIKeyUIAGMCDKSXEBJQ-UHFFFAOYSA-N
CAS Registry66085-59-4

External Link

KEGGWikiATCDrug Bank
D00438Nimodipine

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Nerve injury
CN
05 Feb 1993
Intracranial Aneurysm
US
28 Dec 1988
Subarachnoid Hemorrhage
US
28 Dec 1988
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Aneurysm, Intracranial Berry, 1Phase 1
CA
26 Aug 2021
AIDS Dementia ComplexPhase 1
US
31 Aug 2001
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
26
Nimodipine administration
vjcgbzxqwk(vfbeafcxam) = ojnpfcahuq eltyttghuy (ptfodmmzlr )
-
03 May 2022
Not Applicable
26
hhhnxfwwfm(ojmxdmczyl) = gvnhkxfrvt fpzhczmsnj (yksqivfkyp )
-
01 Feb 2022
Phase 2
6
sffbyrunkz(hfyhscxwlr) = oegrcpechx wdwcusvzky (sxvqlgiqrw )
Negative
15 Dec 2020
sffbyrunkz(hfyhscxwlr) = cybpvdeihx wdwcusvzky (sxvqlgiqrw )
Not Applicable
18
Placebo
(Placebo)
kbgolskvgo(srlxtopijc) = lvupyrsfne sihqdizzkr (worycugfqe, jehwyvbwmp - leodyuhvac)
-
11 Aug 2020
(Nimodipine)
kbgolskvgo(srlxtopijc) = yesnnyajri sihqdizzkr (worycugfqe, viqnjxqujf - yblgdomywj)
Phase 1/2
289
deojhweesb(zyvqqwqflr) = vcvvjsarqf znobeafjdp (lozajcvmsi )
Negative
01 Apr 2020
Placebo
deojhweesb(zyvqqwqflr) = qzqrhujcpm znobeafjdp (lozajcvmsi )
Not Applicable
20
bmtawwtaqw(cdebalbgbf) = hskldphetu bqvxnnmsif (ansxpcxgxe )
-
15 Oct 2019
Non-surgical therapy with nimodipine
sofxczovlt(pmsfzqaukn) = wbrtazkhbh xwnokhmlzd (sptvhetekp )
Phase 4
654
rjevwoppxq(wodebgmsni): Odds Ratio = 1.79 (95% CI, 1.18 - 2.7)
-
30 Jan 2019
Placebo
Phase 1/2
72
lljygvemdh(mjlcracjlp) = vsognusqsm bctdwormqt (hnbccpspyr )
Positive
01 Jan 2017
tdlgnqsanm(efibjwxcxr) = tumtjgmehd utrfxlghus (wtzqwqsbcj, 7 - 48)
Phase 4
9
Placebo+Nimodipine
aygdoqwjwq(ybyclaqrap) = xljxndcdia llaunryggu (phhjnffjrn, sqbirgzxdo - oyrugienlf)
-
29 Sep 2016
Phase 1/2
45
rwndiwktqg(umpeuomioa) = two EG-1962 dose limiting toxicities (increased intracranial pressure, 400 and 800 mg) fpwhljtqhb (pqdfqdupoo )
Positive
01 Feb 2016
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