Delving into the Latest Updates on Beyondbio, Inc. with Synapse

Overview

Basic Info

Introduction

Beyondbio, Inc. is a South Korean-based company situated in Daejeon. Focused on the research and development of drugs for lethal diseases, it was launched in 2013. It's been headed by its founder, Chang-Hee Min.

Tags

Neoplasms

Nervous System Diseases

Respiratory Diseases

Small molecule drug

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Neoplasms	2
Nervous System Diseases	2

Top 5 Drug Type	Count

Small molecule drug	2
Unknown	1

Top 5 Target	Count

CDK1(Cyclin-dependent kinase 1)	1

BACKGROUNDAberrant cell death induced by ischemic stress is implicated in the pathogenesis of ischemic diseases. Fas-associated factor 1 (FAF1) has been identified as a death-promoting protein. This study demonstrates that FAF1 functions in death signaling triggered by ischemic insult.METHODSThe expression changes of FAF1 and phophorylated JNK1 were detected by Western blotting. Immunoprecipitation was employed to investigate protein-protein interaction. We determined the cell death using flow cytometry and lactate dehydrogenase release measurement. To validate the death-promoting role of FAF1 in the retina, we generated conditional retinal FAF1 knockout mice. We used hematoxylin and eosin staining to detect retinal cell death in retinal ganglion cell layer.RESULTSFAF1 was found to function upstream of c-Jun N-terminal kinase 1 (JNK1), followed by mitochondrial dysregulation and necrotic cell death processes upon ischemic insult. We investigated whether FAF1 is involved in the pathogenesis of ischemic diseases using a retinal ischemia model. Indeed, FAF1 potentiated necrosis through JNK1 activation upon ischemic stress in retinal cells demonstrating retinal ganglion-like character. Conditional FAF1 depletion attenuated JNK1 activation in the retinas of Dkk3-Cre;Faf1^flox/flox mice and ameliorated death of retinal cells due to elevated intraocular pressure (IOP).CONCLUSIONSOur results show that FAF1 plays a key role in ischemic retinal damage and may be implicated in the pathogenesis of retinal ischemic disease.

100 Deals associated with Beyondbio, Inc.

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100 Translational Medicine associated with Beyondbio, Inc.

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Pipeline

Pipeline Snapshot as of 07 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

2

1

Phase 2 Clinical

Other

1

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

BEY-1107P ( CDK1 )	Metastatic Colorectal Carcinoma More	Phase 2 Clinical
BEY-4101C	Lung Cancer More	Preclinical
BEY4101A	Alzheimer Disease More	Preclinical
BEY-2153 ( APP x TAU )	Alzheimer Disease More	Pending