Zirconia to platinum alloy braze joints were made using titanium-nickel interlayers of 3 different weight compositions The process was carried out under vacuum at 950-1150°. Microstructure evolution was investigated by SEM, energy-dispersive spectroscopy and x-ray diffraction anal. The interfacial reaction product (Ti,Zr)O2 is responsible for the ceramic side bond development, while Pt diffused into the interlayer forms the microstructure on the noble metal side of the joint. Evolution of microstructure is influenced by temperature No elemental nickel is detected in the joint after brazing. The zirconia-platinum alloy joint is a potential candidate for biomedical applications.