Guangzhou Ruiling Pharmaceutical Co., Ltd.

Part I: Topical single-dose escalation (SAD) of RGL-2102 in patients with chronic wounds Main study objectives: To evaluate the safety and tolerability of topical single-dose administration of topical RGL-2102 in patients with chronic wounds; Secondary study objectives: To evaluate the pharmacokinetic (PK) characteristics of topical single-dose administration of topical RGL-2102 in patients with chronic wounds; To evaluate the immunogenicity of topical single-dose administration of topical RGL-2102 in patients with chronic wounds. Part II: Multiple escalating doses (MAD) of topical RGL-2102 in patients with chronic wounds Main study objectives: To evaluate the safety and tolerability of multiple topical administration of topical RGL-2102 in patients with chronic wounds; Secondary study objectives: To evaluate the pharmacokinetic (PK) characteristics of multiple topical administration of topical RGL-2102 in patients with chronic wounds; To evaluate the immunogenicity of multiple topical administration of topical RGL-2102 in patients with chronic wounds; To evaluate the preliminary efficacy of multiple topical administration of topical RGL-2102 in patients with chronic wounds.