Aravive Biologics, Inc.

Toronto, Ontario--(News - January 30, 2024) - Telo Genomics Corp. (TSXV: TELO) (OTCQB: TDSGF) (the "Company" or "Telo") is pleased to announce that it has engaged Trusted Health Advisors (THA), a market leader specialized in guiding commercialization programs of innovative diagnostics products in the USA. THA will work with Telo's team to refine and accelerate Telo's go-to-market and partnership deployment plan, to facilitate the implementation of Telo's biomarker services for basic and clinical research and clinical diagnostic applications in Multiple Myeloma and the broader cancer field. The program will include facilitating partnerships and collaborations with basic and clinical researchers, Biopharmaceutical companies, Clinical Research Organizations (CROs), clinical laboratories and oncology providers and healthcare systems. THA's engagement with Telo will be led by veterans in the diagnostics industry including Jay Wohlgemuth, MD; Ray Tabibiazar, MD; Richard Bender, MD; and Mr. Paul Owen. The team will also draw on the expertise of additional THA partners ( ). Dr. Wohlgemuth has many years of experience leading healthcare innovation efforts in diagnostic testing, medical devices, virtual care and digital health, and pharmaceutical and companion diagnostics development. Dr. Wohlgemuth served as CMO, CSO and SVP for Quest Diagnostics over a period of 14 years. He also served as CMO of HealthTap, as well as development team leader at Genentech / Roche for Ocrelizumab (Ocrevus) in multiple sclerosis and rheumatology, and as director of diagnostics for programs outside of oncology. Dr. Wohlgemuth was co-founder, CMO and VP R&D for CareDx, a leader in testing for transplant patients, for which he was awarded Technology Pioneer 2005 at the World Economic Forum in Davos. He also served as Chairman of the Board of the Personalized Medicine Coalition. Dr. Tabibiazar is a seasoned executive with leadership experience in the healthcare and biopharma industries, including venture capital, pharmaceuticals and diagnostics. As a clinician-entrepreneur and managing director of "526 Ventures", he has focused on creating new ventures in the form of new companies or spinouts to translate innovative science into commercially viable products. Dr. Tabibiazar serves as Chair at SalioGen Therapeutics, and previously led Aravive Biologics as CEO, served as SVP, Corporate Development and Business Strategy at Twist Bioscience, and as a Venture Partner at Bay City Capital. Dr. Bender is a board-certified oncologist who brings more than 40 years of experience in hematological malignancy with a special focus on multiple myeloma ("MM"). He received his medical degree from the UCLA School of Medicine and completed his internship and residency at UCLA-Harbor General Hospital followed by a hematology/oncology fellowship at the National Cancer Institute. His past titles include Medical Director for Hematology/Oncology for Quest Diagnostics, Medical Director for Hematology/Oncology for Kaiser Permanente, and Chief Medical Officer for both Agendia and Signal Genetics. Dr. Bender has also served on the executive board of the American Cancer Society and has been retained by the FDA as a member of the Hematology and Pathology Devices Advisory Committee. He has authored more than 80 peer-reviewed scientific articles and book chapters. Mr. Owen is currently a Managing Partner at Trusted Health Advisors (THA). Prior to joining THA, Paul served as the President and Interim CEO of imaware, a digital health platform providing advanced home-based testing and monitoring experiences throughout the pandemic. Mr. Owen has had a very productive and successful career in developing and bringing healthcare innovation to market. He previously served as Chief Business Officer and COO for Kailos Genetics and CEO of OneOme, an innovator in precision medicine and pharmacogenetics, co-founded by the Mayo Clinic. Prior to joining OneOme Paul led global commercialization for Invitae, a leader in hereditary disease diagnostics testing. Previously, Mr. Owen served as Vice Chair of Global Business Development for the Mayo Clinic and was the leader of Mayo Medical Laboratories' global commercial team - one of the world's largest full-service reference labs and held leadership roles at Zimmer-Biomet and Boston Scientific. Driven by the progress of Telo's clinical studies that were presented at several leading oncology scientific and clinical conferences in 2023, and as part of the Company's commercialization strategy, the Company has prioritized the engagement of THA to guide the implementation of the technology in both biomarker research and clinical diagnostics markets, and form partnerships to facilitate the adoption of the advanced biomarker research services as well as predictive and prognostic tests for MM. In addition, THA will provide support and direction with respect to regulatory pathways, product development, launch and marketing initiatives. "We are very excited to work with the Telo Genomics' team and to lead the Company's go-to-market strategy," said Mr. Owen, who is Managing Partner, THA and is leading the collaboration. "The TeloView platform offers a broad spectrum of valuable applications for oncology management with robust scientific and clinical evidence. The platform also enables the most advanced analysis and characterization of Telomeres for Basic and Clinical Researchers, Pharma, Oncology organizations and CROs." About Multiple Myeloma Multiple myeloma is a challenging and potentially deadly blood cancer that involves plasma cells, a type of blood cell that helps to fight infection. It is the second most common blood cancer with an incidence of 35,000 new cases every year in the US, and ~180,000 patients receiving treatment at any given time. Although the introduction of new generation therapy, including targeted immunotherapy, has increased the median survival rate to over 5 years, MM is still considered incurable. Two asymptomatic precursors, MGUS and SMM generally precede the progression to classic, symptomatic MM at yearly rates of 1% from MGUS and at 15% from SMM, respectively. To date, identifying patients who will more rapidly progress to active MM remains an important unmet clinical need. MM treatment includes various combinations of drugs with a cost as high as $150,000 per year per patient. As most patients will develop resistance to treatment and relapse within a median of 2 years, identifying them proactively remains another important and unmet need. Notably, the total addressable market for both of these MM assays is over 750,000 tests per year in the US. About TELO Telo Genomics Corp. is a biotech company pioneering the most comprehensive telomere platform in the industry with powerful applications and prognostic solutions. These include liquid biopsies and related technologies in oncology and neurological diseases. Liquid biopsy is a rapidly growing field of significant interest to the medical community for being less invasive and more easily replicated than traditional diagnostic approaches. By combining our team's considerable expertise in quantitative analysis of 3D telomeres with molecular biology and artificial intelligence to recognize disease associated genetic instability, TELO is developing simple and accurate products that improve day-to-day care for patients by serving the needs of pathologists, clinicians, academic researchers and drug developers. The benefits of our proprietary technology have been substantiated in 160+ peer reviewed publications and in 30+ clinical studies involving more than 3,000 patients with multiple cancers and Alzheimer's disease. Our lead application, TELO-MM is being developed to provide important, actionable information to medical professionals in the treatment of multiple myeloma, a deadly form of blood cancer. For more information please visit . For further information, please contact: Sherif Louis, President & CTO 416-673-8487 info@telodx.com MaRS Centre, South Tower, 101 College Street, Suite 200, Toronto, ON, M5G 1L7 Neither the TSX Venture Exchange nor its Regulation Services Provider (as such term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release. Cautionary Note Regarding Forward-Looking Statements Certain information contained herein may constitute "forward-looking information" under Canadian securities legislation. Generally, forward-looking information can be identified by the use of forward-looking terminology such as "intends", "will", or variations of such words and phrases or statements that certain actions, events or results "will" occur. Forward-looking statements regarding the clinical efficacy of products, commercial viability of products, use of proceeds, and the ability of the TeloView® platform to deliver personalized medicine resulting in better treatments and outcomes are based on the Company's estimates and are subject to known and unknown risks, uncertainties and other factors that may cause the actual results, level of activity, performance or achievements of the Company to be materially different from those expressed or implied by such forward-looking statements or forward-looking information, including capital expenditures and other costs. There can be no assurance that such statements will prove to be accurate, as actual results and future events could differ materially from those anticipated in such statements. Accordingly, readers should not place undue reliance on forward- looking statements and forward-looking information. The Company will not update any forward-looking statements or forward-looking information that are incorporated by reference herein, except as required by applicable securities laws. To view the source version of this press release, please visit

DUBLIN, June 2, 2023 /PRNewswire/ -- The "Global Musculoskeletal Partnering 2016-2023: Deal Trends, Players and Financials" report has been added to ResearchAndMarkets.com's offering. This report provides the full collection of musculoskeletal disease deals signed between the world's pharmaceutical and biotechnology companies since 2016. Trends in musculoskeletal partnering deals Financial deal terms for headline, upfront and royalty by stage of development Musculoskeletal partnering agreement structure Musculoskeletal partnering contract documents Top musculoskeletal deals by value Most active musculoskeletal dealmakers Most of the deals included within the report occur when a licensee obtains a right or an option right to license a licensor's product or technology. More often these days these deals tend to be multi-component including both a collaborative R&D and a commercialization of outcomes element. The report takes readers through the comprehensive musculoskeletal disease deal trends, key players and top deal values allowing the understanding of how, why and under what terms companies are currently entering musculoskeletal deals. The report presents financial deal terms values for musculoskeletal deals, where available listing by overall headline values, upfront payments, milestones and royalties enabling readers to analyse and benchmark the value of current deals. Report scope The report is intended to provide the reader with an in-depth understanding and access to musculoskeletal trends and structure of deals entered into by leading companies worldwide. Global Musculoskeletal Partnering 2016 to 2023 includes: Trends in musculoskeletal dealmaking in the biopharma industry since 2016 Access to headline, upfront, milestone and royalty data Access to hundreds of musculoskeletal deal contract documents Comprehensive access to over 600 musculoskeletal deal records The leading musculoskeletal deals by value since 2016 Most active musculoskeletal dealmakers since 2016 The report includes deals for the following indications: Arthritis, Ankylosing spondylitis, Juvenile arthritis, Osteoarthritis, Psoriatic arthritis, Rheumatoid arthritis, Bone fracture, Hip, Carpel tunnel syndrome, Frozen shoulder, Gout, Knee, Meniscus damage, Muscular dystrophy, Osteoporosis, Paget's disease, Spinal muscular atrophy, Bone pain, Back pain, Muscular pain, Stiffness, Weakness, plus other musculoskeletal indications. In Global Musculoskeletal Partnering 2016 to 2023, available deals and contracts are listed by: Headline value Upfront payment value Royalty rate value Stage of development at signing Deal component type Technology type Specific therapy indication Each deal title links via Weblink to an online version of the deal record and where available, the contract document, providing easy access to each contract document on demand. The Global Musculoskeletal Partnering 2016-2023 report provides comprehensive access to available deals and contract documents for over 600 musculoskeletal deals. Analyzing actual contract agreements allows assessment of the following: What are the precise rights granted or optioned? What is actually granted by the agreement to the partner company? What exclusivity is granted? What is the payment structure for the deal? How are the sales and payments audited? What is the deal term? How are the key terms of the agreement defined? How are IPRs handled and owned? Who is responsible for commercialization? Who is responsible for development, supply, and manufacture? How is confidentiality and publication managed? How are disputes to be resolved? Under what conditions can the deal be terminated? What happens when there is a change of ownership? What sublicensing and subcontracting provisions have been agreed? Which boilerplate clauses does the company insist upon? Which boilerplate clauses appear to differ from partner to partner or deal type to deal type? Which jurisdiction does the company insist upon for agreement law? Key Topics Covered: Chapter 1 - Introduction Chapter 2 - Trends in musculoskeletal dealmaking 2.1. Introduction 2.2. Musculoskeletal partnering over the years 2.3. Musculoskeletal partnering by deal type 2.4. Musculoskeletal partnering by industry sector 2.5. Musculoskeletal partnering by stage of development 2.6. Musculoskeletal partnering by technology type 2.7. Musculoskeletal partnering by therapeutic indication Chapter 3 -Financial deal terms for musculoskeletal partnering 3.1. Introduction 3.2. Disclosed financials terms for musculoskeletal partnering 3.3. Musculoskeletal partnering headline values 3.4. Musculoskeletal deal upfront payments 3.5. Musculoskeletal deal milestone payments 3.6. Musculoskeletal royalty rates Chapter 4 - Leading musculoskeletal deals and dealmakers 4.1. Introduction 4.2. Most active in musculoskeletal partnering 4.3. List of most active dealmakers in musculoskeletal 4.4. Top musculoskeletal deals by value Chapter 5 - Musculoskeletal contract document directory 5.1. Introduction 5.2. Musculoskeletal partnering deals where contract document available Chapter 6 - Musculoskeletal dealmaking by therapeutic target 6.1. Introduction 6.2. Deals by musculoskeletal therapeutic target Companies Mentioned 3D-Side 3SBio A2A Pharmaceuticals Aavis Pharmaceuticals Abarca Abbvie AbCellera AC Bioscience Accenture Actigraph Activbody Active Implants Adaptive Health Additive Orthopaedics Advanced Human Imaging AdventHealth Affinia Therapeutics AGC Asahi Glass AgNovos Healthcare AgomAb Therapeutics Akashi Therapeutics AKL Research and Development AlfaMed Aligos Therapeutics AliMed Alkem Laboratories Allergan AlloSource Almirall Alpine Immune Sciences Altamira Bio Altasciences Alvogen Alvotech Ambry Genetics Amedica Amend Surgical American Association of Neuromuscular & Electrodiagnostic Medicine Amgen Amneal Pharmaceuticals AMRA AMRA Medical Anagenesis Biotechnologies Analysis Group AnaMar Angelini Pharma Angers University Anika Therapeutics ANI Pharmaceuticals Antares Pharma Antibe Therapeutics Apexigen Apple Apsen Farmacutica Aptahem Aptorum Group Aralez Pharmaceuticals Aratana Therapeutics Aravive Biologics argenx ARK Crystal Arrowhead Pharmaceuticals Arthrex Arthrosi Therapeutics Artialis Asahi Kasei Ascendis Pharma AskAt Asklepios Biopharmaceutical Assertio Therapeutics Astellas Pharma AstraZeneca Athrotech Atnahs Pharma Audentes Therapeutics Aurinia Pharmaceuticals Australian Research Council Autotelic BIO Avalere Health Avanos Medical Aveta Biomics AveXis Avidity Biosciences Avion Pharmaceuticals AWB Schraubtechnik und Industriebedarf Axovant Gene Therapies Azellon Cell Therapeutics Aziyo Biologics Back-A-Line Bacterin International Baebies Bamboo Therapeutics Bauerfeind Baxalta Bayer Baylor College of Medicine Bazis NN BC Platforms Beijing Tide Pharmaceutical Benitec Biopharma Berg BGI BillionToOne Bio-Thera Solutions BioAge Labs BioCanRx Biocomposites Biogen BioGen Medical Biohaven Pharmaceuticals BioInvent BioMarin Pharmaceutical BioMed X Innovation Center BionX Medical Technologies BioPharma Forest Bioqube Ventures Bioservo Technologies Biosolution Biosplice Bioventus BioVinc Bison & Rose Blue Belt Technologies Blueprint Medicines Bodycad Boehringer Ingelheim Bone Biologics Bone Therapeutics Brickell Biotech Brigham and Women's Hospital Bristol-Myers Squibb BRM Extremities BSN Medical Burke Therapeutics c-LEcta California Institute for Biomedical Research California Institute for Regenerative Medicine Calimmune Calliditas Therapeutics Camargo Pharmaceutical Services Camber Spine Technologies Can-Fite BioPharma CANbridge Pharmaceuticals Cantargia Capricor Therapeutics Capsigen CareFirst BlueCross BlueShield Carlsmed Carna BioSciences CartiHeal Cartiva CAS Casper Pharma Catabasis Pharmaceuticals Catalyst Pharmaceuticals cbdMD Cedars-Sinai Medical Center Celgene Celltech Cellthera Pharma Cell Therapy Catapult Celltrion Cellular Biomedicine Cel Sci Centinel Spine Centogene Cerhum For more information about this report visit About ResearchAndMarkets.com ResearchAndMarkets.com is the world's leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends. Media Contact: Research and Markets Laura Wood, Senior Manager [email protected] For E.S.T Office Hours Call +1-917-300-0470 For U.S./CAN Toll Free Call +1-800-526-8630 For GMT Office Hours Call +353-1-416-8900 U.S. Fax: 646-607-1907 Fax (outside U.S.): +353-1-481-1716 Logo: SOURCE Research and Markets

BERWYN, Pa., May 11, 2023 (GLOBE NEWSWIRE) -- Annovis Bio, Inc. (NYSE: ANVS) (“Annovis” or the “Company”), a clinical-stage drug platform company addressing neurodegenerative diseases, announced first quarter financial results for the period ended March 31, 2023, and reviewed recent accomplishments. First Quarter 2023 Highlights and New Developments Clinical UpdatesAt a recent R&D webcast on April 20, 2023, the Company: Reviewed its ongoing clinical programs in AD and PD.Discussed preliminary plans to develop buntanetap with the FDA for all stages of diseases, both short- and long-term.Provided updates to its then current enrollment levels for each trial: AD Phase 2/3 study: 27 sites had been activated and 38 patients had been screened as of April 20; 13 patients had been randomized to receive either one of three doses of buntanetap or placebo.PD Phase 3 study: Over 540 patients had been screened and 385+ patients were on the drug as of April 20. Due to U.S clinical sites opening earlier than EU sites, there were approximately four times more U.S. patients enrolled in the study versus EU patients. To accommodate the strong enrollment trends in the U.S. excess supplies of buntanetap were shipped from the EU to the U.S. PD Updates Explained the results from the pre-planned blinded interim analysis of the ongoing Phase 3 study for early PD, announced on March 31, 2023. The analysis was based on 132 patients from all cohorts collectively for which baseline and two-month data was available. The results enabled the Company to move forward with the previously established protocol and original patient enrollment estimates for the trial. Announced on February 8, 2023, the approval by the EU to start clinical trials in five EU countries for the ongoing Phase 3 study of buntanetap for the treatment of early PD. Annovis is actively recruiting for the ongoing Phase 3 study, with approximately 53 clinical trial sites open and currently enrolling in the U.S. The approval adds approximately 49 additional sites in the EU for the Company's ongoing study. Patents Announced on February 1, 2023, the filing of a provisional patent application that extends the breadth of its platform from neurodegenerative to neuropsychiatric indications to cover the administration of buntanetap and its analogues for the treatment of mental illnesses.Announced on April 27, 2023, the issuance of U.S. Patent 11,596,621 B2 by the United States Patent and Trademark Office titled, “Prevention or Treatment of Disease States Due to Metal Dis-homeostasis Via Administration of Posiphen [buntanetap] to Healthy or Sick Humans.” The patent is expected to confer protection for use of buntanetap and its related analogue molecules for the prevention and treatment of various neurodegenerative diseases associated with metal dis-homeostasis out to early 2040. Financial Results (for the quarter ending March 31, 2023) Cash and cash equivalents were $16.8 million. Research and development expenses for the quarter were $7.8 million, compared to $2.1 million for the same period in 2022. The increase was primarily the result of an increase of $5.6 million in clinical expenses, as the Company incurred costs related to its Phase 3 study in early Parkinson’s Disease (PD) patients and its Phase 2/3 Alzheimer's Disease (AD) study, partially offset by a decrease of $0.4 million in stock-based compensation expense.General and administrative expenses for the first quarter were $2.2 million, compared to $3.1 million for the same period in 2022. The decrease was primarily the result of a decrease of $1.5 million in stock-based compensation expense, partially offset by an increase in professional fees of $0.6 million.Annovis reported a net loss of $9.7 million for the quarter, compared to a net loss of $5.2 million for the same period in 2022. Raised Approximately $8.7 million The Company announced on April 11, 2023, that it had raised aggregate gross proceeds of approximately $8.7 million between its now-terminated at–the-market (ATM) program and a private placement to individual members of its Board of Directors and management. The additional capital will fund the company's two ongoing studies (Phase 3 in early PD and Phase 2/3 in moderate AD) through completion and otherwise fund operations into the first quarter of 2024. Staff News New appointments will strengthen the Company’s senior leadership team: The Company announced on January 6, 2023, the appointment of Michael Christie, Ph.D. as Vice President of Process Chemistry, and David Prohaska as Vice President of Toxicology and Pharmacology. Dr. Christie has over 40 years of experience in the pharmaceutical industry and formally served as the Senior Director of Chemical Process and R&D for Teva Pharmaceuticals. Prohaska brings 25 years of experience in all aspects of preclinical drug development and has a long track record of successful FDA submissions with multiple drug approvals. He joined Annovis from Aravive Biologics where he served as the Director of Preclinical Development and Clinical Operations Support. Presented at the AD/PD™ 2023 International Conference on Alzheimer's and Parkinson's Diseases (April 1, 2023): The Company presented data combining and comparing old data in mice and new data in humans to show that mouse and rat data are predictive of human outcomes. In the presentation, titled "Do Mouse Data Lie? For Buntanetap They Totally Predict Human Outcome", data from the AD mice, Down Syndrome mice, PD mice, two Phase 1/2 double-blind, placebo-controlled human AD studies and one Phase 2 PD study were compared to show the consistency on buntanetap's mechanism of action, the reversal of the toxic cascade, and the resulting efficacy in AD and PD mice and humans.Message from Dr. Maria As highlighted during our R&D webinar, Annovis continues to make significant progress in our ongoing Alzheimer’s and Parkinson’s clinical programs. Enrollment in the Phase 3 Parkinson’s study remains exceptionally strong and reflects our team’s excellent operational execution and the growing interest in the therapeutic potential of our lead pipeline candidate, buntanetap. Given our continued execution and the growing momentum in these two programs, we were able to strengthen our balance sheet with both new and existing investors, including several members from our Board of Directors. Thus far, 2023 is proving to be a momentous year for our Company, and with additional data readouts anticipated later this year, we remain on track for delivering what we hope will be positive news for our clinical programs. We remain steadfast in our mission to develop truly groundbreaking therapies for both AD and PD patients. –Maria L. Maccecchini, Ph.D., Annovis Founder, President, and CEO About BuntanetapBuntanetap (previously known as ANVS401 or Posiphen) is an oral translational inhibitor of neurotoxic aggregating proteins (TINAPs), which mode of action leads to a lower level of neurotoxic proteins and consequently less toxicity in the brain. In a Phase 1/2 clinical trial in AD and PD patients, buntanetap was shown to be well-tolerated and its pharmacokinetics were found to be in line with levels measured earlier in humans, meeting both the primary and secondary endpoints. Additionally, exploratory endpoints were also met, as treatment with buntanetap resulted in statistically significant improvement in motor function in PD patients and cognition in AD patients. Presently buntanetap is being studied in a Phase 3 study in early PD patients and in a Phase 2/3 study in mild to moderate AD patients. About Annovis Bio, Inc.Headquartered in Berwyn, Pennsylvania, Annovis Bio, Inc. (Annovis) is a clinical-stage, drug platform company addressing neurodegeneration, such as Alzheimer’s Disease (AD), Parkinson’s Disease (PD), and other chronic neurodegenerative diseases. We believe that we are the only company developing a drug for AD and PD that is designed to inhibit more than one neurotoxic protein and has a mechanism of action designed to restore axonal and synaptic activity. By improving brain function, the company’s goal is to treat memory loss and dementia associated with AD as well as body and brain function associated with PD. Annovis conducted two Phase 1/2 studies: one in AD patients and one in both AD and PD patients. In the AD/PD study buntanetap showed improvements in cognition in AD as well as movement and function in PD patients. For more information on Annovis Bio, please visit the Company's website www.annovisbio.com and follow us on LinkedIn and Twitter. Forward-Looking StatementsThis press release contains "forward-looking" statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. All statements other than statements of historical fact are statements that could be deemed forward-looking statements. The Company advises caution in reliance on forward-looking statements. Forward-looking statements include, without limitation, the Company's plans related to clinical trials. These statements involve known and unknown risks, uncertainties and other factors that may cause actual results to differ materially from those implied by forward-looking statements, including regarding patient enrollment, the effectiveness of Buntanetap and the timing, effectiveness, and anticipated results of the Company's clinical trials evaluating the efficacy, safety and tolerability of Buntanetap. See also additional risk factors set forth in the Company's periodic filings with the SEC, including, but not limited to, those risks and uncertainties listed in the section entitled "Risk Factors," in the Company's Annual Report on Form 10-K and Quarterly Reports on Form 10-Q filed with the SEC. All forward-looking statements in this press release are based on information available to the Company as of the date of this filing. The Company expressly disclaims any obligation to update or alter its forward-looking statements, whether as a result of new information, future events or otherwise, except as required by applicable law. Investor Contacts: Chris Calabrese+1 (917) 680-5608ccalabrese@lifesciadvisors.comLifeSci Advisors, LLC Kevin Gardner+1 (617) 283-2856kgardner@lifesciadvisors.com LifeSci Advisors, LLC SOURCE Annovis Bio