Effectiveness of a Microbiome-directed Food to Promote Programmatic and Sustained Nutritional Recovery Among Children With Uncomplicated Acute Malnutrition

This study is an individually randomized controlled trial comparing microbiome-directed foods to standard nutritional therapy among children aged 6 to < 24 months with uncomplicated acute malnutrition in terms of programmatic recovery by 12 weeks from admission and sustained recovery at 24 weeks from admission.

Start Date02 May 2024

Sponsor / Collaborator

Epicentre Technologies Corp.

PACTR202112574484846 / RecruitingPhase 4

Determining whether mass campaigns with fractional dose PCV10 would accelerate herd protection against pneumococcal transmission in Sub-Saharan Africa

Start Date22 Dec 2021

Sponsor / Collaborator

Epicentre Technologies Corp.

NCT04331847 / Unknown statusNot Applicable

AMoCo Study: Abortion-related Morbidity and Mortality in Conflict-affected and Fragile Settings Study

To describe and estimate the burden of abortion-related complications, particularly near-miss complications and deaths, and their associated factors among women presenting for abortion-related complications in health facilities supported by Médecins Sans Frontières (MSF) in African fragile and/or conflict-affected settings.

Start Date03 Sep 2019

Sponsor / Collaborator

Epicentre Technologies Corp.

[+3]

100 Clinical Results associated with Epicentre Technologies Corp.

0 Patents (Medical) associated with Epicentre Technologies Corp.

Literatures (Medical) associated with Epicentre Technologies Corp.

16 Jun 2020·Near-Infrared Applications in Biotechnology

Near-Infrared Applications in DNA Sequencing and Analysis

Author: Raghavachari, Ramesh ; Meis, Ronald J.

A review on the use of near-IR dyes for fluorescence detection in automated DNA sequencing systems.These dyes offer several advantages over that of visible-wavelength dyes.The biol. and chem. of the sequencing process are the same as those of any visible detection systems.Near-IR detection provides researchers with attractive alternatives to the use of visible-wavelength fluorescent dyes.

15 Apr 2011·Cancer Research

Abstract 4857: Improved technology for ribosomal RNA (rRNA) removal from formalin-fixed paraffin-embedded (FFPE) total RNA

Author: Sooknanan, Roy ; Radek, Agnes ; Khanna, Anupama ; Hitchen, John

AbstractDeep, massively parallel sequencing of cDNA generated from RNA (“RNA-Seq”) is rapidly gaining momentum for transcript profiling, discovery of novel transcripts, and identification of alternative splicing events. Current methods for making sequencer-specific di-tagged DNA fragment libraries for RNA-Seq typically comprise first, preparing rRNA-depleted RNA from total RNA samples that are usually of good quality followed by the synthesis of the di-tagged cDNA sequencing templates. In the past few years however, it has also become evident from microarray and qPCR studies that formalin-fixed paraffin-embedded (FFPE) cancer tissues hold valuable secrets about diseased states. However, RNA-Seq libraries prepared from such highly fragmented FFPE RNA cancer samples yield limited information since these libraries contain a majority of rRNA reads, which decreases sequencing depth and coverage. Current commercially available rRNA-removal kits are not designed to remove fragments of rRNA, which poses a significant limitation for preparing highly informative RNA-Seq libraries from FFPE RNA samples.Here, we present RNA-Seq results obtained using a novel rRNA removal technology (“Ribo-ZERO™”) and a novel, ligation-free process for preparing directional di-tagged DNA fragment libraries (“ScriptSeq™ Technology”) for RNA-Seq. Using these methods, directional di-tagged DNA fragment libraries can be prepared in about 6 hours from either intact or fragmented (e.g., FFPE) total RNA samples (as little as 100 ng FFPE total RNA sample required). Less than 2 % of the sequence reads from libraries generated from total RNA from either intact or FFPE samples map to rRNA sequences (28S, 18S, 5.8S and 5S). This reduction in rRNA sequence reads from FFPE RNA samples improves sequence depth and coverage, and increases the percentage of uniquely mapped reads, increasing the information obtained from these diseased samples.Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4857. doi:10.1158/1538-7445.AM2011-4857

01 Jan 2011·Methods in Molecular Biology

Random Chromosomal Gene Disruption In Vivo Using Transposomes

Article

Author: Hoffman, Les M

Strain engineering of bacteria has been accomplished by many methods where mobile DNA elements (transposons) are inserted into the genomic DNA of a host organism. This chapter addresses engineering with transposable elements complexed with transposase enzyme. In traditional techniques, transposon and transposase are introduced as distinct entities. The method of mobilization into cells is often unique for each class of DNA element, and for each organism. The discovery of pre-formed transposon/transposase complexes (transposomes) that can be electroporated into living cells opens a new gateway to strain mutagenesis. Described are the preparation of electrocompetent bacterial cells and their transformation with transposomes. Once within the cell, the transposome is equipped to randomly insert its DNA into chromosomes without needing additional components. Ocr, a T7 phage protein that inhibits the host restriction of electroporated DNAs, will also be discussed as an adjunct reagent that can widen the applicability of transposomes. The transposomes used in most of the applications are commercially available, but also described is the process of making custom transposon DNAs and transposomes. The techniques are not limited to bacterial strain engineering per se and may be adapted for single-cell eukaryotes as well.

100 Deals associated with Epicentre Technologies Corp.

100 Translational Medicine associated with Epicentre Technologies Corp.

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