Nanjing Core Tech Co. Ltd.

Main research purpose: According to the relevant provisions of bioequivalence test, Teva Sante is the licensee of phloroglucinol orodisintegrating tablets (specification: 80mg) as the reference preparation, and the test preparation phloroglucinol orodisintegrating tablets (specification: 80mg) produced by Nanjing Jinling Pharmaceutical Factory of Jinling Pharmaceutical Co., Ltd. and provided by Nanjing Aidekaiteng Biomedicine Co., Ltd. are conducted on the human bioequivalence test of fasting and postprandial administration, to compare whether the absorption rate and degree of the drug in the test preparation are within the acceptable range with the reference preparation, and to evaluate the bioequivalence of the two preparations under fasting and postprandial administration conditions. Secondary research purpose: To observe the safety of oral administration of the test preparation phloroglucinol orodisintegrating tablets (specification: 80mg) and the reference preparation phloroglucinol orodisintegrating tablets (specification: 80mg) by healthy volunteers.

Main research purpose: According to the relevant provisions of bioequivalence test, the oral lyophilized tablets of phloroglucinol (trade name: Spasfon Lyoc, specification: 80mg) of Teva Sante as the licensee were selected as the reference preparation, and the test preparation of oral lyophilized tablets of phloroglucinol (specification: 80mg) produced by Beijing Xinghao Yingsheng Pharmaceutical Co., Ltd. and provided by Nanjing Aidekaiteng Biomedicine Co., Ltd. were subjected to human bioequivalence test on fasting and postprandial administration, to compare whether the absorption rate and degree of the drug in the test preparation were within the acceptable range with the reference preparation, and to evaluate the bioequivalence of the two preparations under fasting and postprandial administration conditions. Secondary research purpose: To observe the safety of oral administration of the test preparation of oral lyophilized tablets of phloroglucinol (specification: 80mg) and the reference preparation of oral lyophilized tablets of phloroglucinol (trade name: Spasfon Lyoc, specification: 80mg) by healthy volunteers.

To evaluate the bioequivalence and safety of avanafil tablets (200 mg) produced by Shanghai Huilun Jiangsu Pharmaceutical Co., Ltd. and avanafil tablets (STENDRA®, 200 mg) produced by VIVUS, Inc. in the United States in healthy adult males after single oral administration on an empty stomach or after a meal.