The Study on the еffectiveness of the Integration of a Device Based on a Neural Interface and Neurostimulation of the Spinal Cord in the Rehabilitation of Patients With Upper Limb Movement Impairments Due to Neurological Disorders.

The aim of the study is to investigate the effectiveness of a new rehabilitation technology for paralysis that occurs after stroke or spinal cord injury. The research will jointly use a prototype neurorehabilitation orthosis, in which a robotic device moves a paralyzed arm at the command of a non-invasive brain-computer interface to perform a game life-like task augmented using a virtual-reality display, as well as an electrical stimulation device that activates the spinal cord and/or muscles of the paralyzed arm.
Investigators expect that a portion of the patients participating in the study will have an improvement in arm mobility by the end of the study.
Participants who express their special written consent will have venous blood tests conducted three times for subsequent analysis of lipid biomarkers, in order to further evaluate the effectiveness of rehabilitation methods based on biochemical analysis.

Start Date01 Oct 2021

Sponsor / Collaborator

Skolkovo Institute of Science & Technology

[+3]

NCT03244969 / WithdrawnNot ApplicableIIT

Study of the Granulation Tissue Formation in the Early Fracture Hematoma

The aim of the research is to identify structural tissue changes in the early fracture hematomas.

Start Date01 Aug 2017

Sponsor / Collaborator

Kazan Federal University

NCT02352649 / Unknown statusPhase 1/2IIT

1-2 Phase of Safety and Efficacy of Patient Intraneural Injections of VEGF165 Plasmid Gene Therapy on Regeneration After Total Severance or Disruption of the Entire Nerve Fiber

The purpose of this study is to determine safety and efficacy of pl-vegf165 ("Neovasculgen") for regeneration of peripheral nerve. Pl-vegf165 ("Neovasculgen") is the permitted in Russian Federation angiogenic medication that induce growth of new vessels and included in a complex therapy for patients with peripheral arterial diseases in Russia. It has also been shown to enhance nerve regeneration and muscle reinnervation in animals but these properties have not previously been studied in patients. Moreover, currently there is no method in clinical use to speed the rate of recovery after nerve injury. The objective of this study is to explore the ability of pl-vegf165 to benefit the treatment of patients with peripheral nerve injury. The investigators hypothesize that treatment with intraneural injections with pl-vegf165 after peripheral nerve reconstruction will accelerate nerve regeneration, reduce the period of denervation and improve muscle reinnervation and recovery in patients with peripheral nerve injury.

Start Date01 Apr 2015

Sponsor / Collaborator

Kazan Federal University

100 Clinical Results associated with Kazan Federal University

0 Patents (Medical) associated with Kazan Federal University

19,136

Literatures (Medical) associated with Kazan Federal University

01 Jan 2025·Fuel

Unified scaling model for viscosity of crude oil over extended temperature range

Author: Mokshin, Anatolii V. ; Doronina, Maria A. ; Galimzyanov, Bulat N.

The viscosity of crude oil is an important phys. property that largely determines the fluidity of oil and its ability to seep through porous media such as geol. rock.Predicting crude oil viscosity requires the development of reliable models that can reproduce viscosity over a wide range of temperatures and pressures.Such viscosity models must operate with a set of phys. characteristics that are sufficient to describe the viscosity of an extremely complex multi-phase and multi-component system such as crude oil.The present work considers empirical data on the temperature dependence of the viscosity of crude oil samples from various fields in Russia, China, Saudi Arabia, Nigeria, Kuwait and the North Sea.For the first time, within the reduced temperature concept and using the universal scaling viscosity model, the viscosity of crude oil can be accurately determined over a wide temperature range: from low temperatures corresponding to the amorphous state to relatively high temperatures, at which all oil fractions appear as melts.A novel methodol. for determining the glass transition temperature and the activation energy of viscous flow of crude oil is proposed.A relationship between the parameters of the universal scaling model for viscosity, the API gravity, the fragility index, the glass transition temperature and the activation energy of viscous has been established for the first time.It is shown that the accuracy of the results of the universal scaling model significantly exceeds the accuracy of known empirical equations, including those developed directly to describe the viscosity of petroleum products.

01 Jan 2025·Fuel

Comparative study on the catalytic performance of iron bio-ligated catalysts in heavy oil oxidation

Author: Vakhin, Alexey V. ; Eskin, Alexey A. ; Ostolopovskaya, Olga V. ; Khelkhal, Mohammed A.

The present investigation explores the catalytic efficiency of iron ligated catalysts derived from tall and sunflower oils in the in-situ combustion process for heavy oil oxidationAddressing the challenge of enhancing heavy oil recovery in an environmentally friendly and economically viable manner, this study evaluates the potential of these bio-originated catalysts to improve the oxidation rates of heavy oil components, focusing on the high temperature oxidation region critical for controlling the combustion front.Through a comprehensive exptl. approach involving physicochem. anal. such as IR spectroscopy, X-ray powder diffraction, thermal anal. (TG/DSC), kinetic modeling and thermodn. study, the present research revealed that the iron bio-originated ligands significantly enhance the oxidation process.The catalyst derived from sunflower oil exhibited a superior performance, demonstrating a more pronounced reduction in the activation energy required for heavy oil high temperature oxidation across a wide range of conversions.Specifically, the sunflower oil-based ligand catalyst showed lower activation energies 105.5 kJ/mol for high-temperature oxidation reactions comparing to tall oil-based catalyst (136.4 kJ/mol) and heavy oil (149.1 kJ/mol), highlighting its effectiveness in facilitating and stabilizing the combustion front.Post-oxidation anal. revealed that the Fe-SFO catalyst maintained a more uniform and finer particle size distribution compared to the Fe-TO catalyst.The Fe-SFO catalyst predominantly had particle sizes in the range of 20 to 120 nm, suggesting that its smaller particle size could provide a larger surface area for reaction and enhance the catalyst′s ability to interact with reactants.These findings underline the catalytic capabilities of bio-originated ligands in improving heavy oil recovery processes, suggesting that the adoption of such sustainable catalysts could lead to greener and more efficient chem. processes in the energy sector.

01 Jan 2025·Fuel

Optimization of heavy crude oil recovery using oil-soluble catalyst precursor under electromagnetic heating

Author: Vakhin, Alexey V. ; Kholmurodov, Temurali ; Tajik, Arash ; I. I. Abdelsalam, Yasser ; Nazimov, Nafis A.

In order to improve the heavy oil quality, the electromagnetic (EM) heating method with the addition of metal catalysts has been considered.Oil-soluble catalyst precursors, which consist of a ligand and a metal, prevent their clumping and precipitation by dispersing nanoparticles in oil.Unfortunately, no research was found to investigate the effect of adding this type of catalyst on increasing the efficiency of EM heating and optimizing the recovery of heavy oil.The aim of this paper was to propose nickel-adipic (NOSC) as an oil-soluble catalyst precursor to increase the efficiency of EM heating.A set of 2.45 GHz industrial magnetrons was used as the microwave radiation source with the addition of 1 wt% NOSC (containing 0.39 % Ni) at time intervals of 3, 6 and 9 min.At 9 min, asphaltene and resin content decreased by 21.91 % and 40.07 %, and saturate and aromatic content increased by 11.13 % and 41.3 %, resp.In addition, the viscosity also showed a decrease of about 60 %.Elemental anal. showed 11 %, 13 % and 20 % reduction of sulfur after 3, 6 and 9 min, resp.According to the results of GC-MS, the content of n-C₂₆-C₃₂ compared to the control sample (ACO) was reduced by 2 times in 6 min.In addition, observing the increase in the content of naphthalenes and light alkylbenzenes in aromatic compounds was a proof of the effectiveness of the NOSC catalytic system in heavy oil upgrading.This paper presents a promising approach to enhance the performance of EM heating in heavy crude oil recovery.

100 Deals associated with Kazan Federal University

100 Translational Medicine associated with Kazan Federal University

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