Delving into the Latest Updates on N.C.S.R. Demokritos with Synapse

Overview

Tags

Neoplasms

Endocrinology and Metabolic Disease

Congenital Disorders

Radiopharmaceuticals and diagnostic agent

Diagnostic radiopharmaceuticals

Small molecule drug

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Endocrinology and Metabolic Disease	2
Neoplasms	2
Nervous System Diseases	1

Top 5 Drug Type	Count

Diagnostic radiopharmaceuticals	1
Small molecule drug	1
Peptide Conjugate Radionuclide	1
Radiopharmaceuticals and diagnostic agent	1

Top 5 Target	Count

SSTR2 x SSTR3 x SSTR5	1
CRF receptor(Corticotropin-releasing factor receptors)	1
DAF(Complement decay-accelerating factor)	1

The work herein reviews the scientific literature on Machine Learning approaches for financial risk assessment using financial reports. We identify two prominent use cases that constitute fundamental risk factors for a company, namely misstatement detection and financial distress prediction. We further categorize the related work along four dimensions that can help highlight the peculiarities and challenges of the domain. Specifically, we group the related work based on (a) the input features used by each method, (b) the sources providing the labels of the data, (c) the evaluation approaches used to confirm the validity of the methods, and (d) the machine learning methods themselves. This categorization facilitates a technical overview of risk detection methods, revealing common patterns, methodologies, significant challenges, and opportunities for further research in the field.

01 May 2025·Carbon

Controlling the morphology of nanocarbons produced by CO2 molten salt electrolysis: Critical role of the electrode material

Author: Sakellis, E. ; Trapalis, C. ; Plakantonaki, N. ; Todorova, N. ; Giannakopoulou, T.

The present study concerns the electrochem. conversion of greenhouse gas CO₂ to solid nanocarbons in low temperature (500°) eutectic mixture of Li-K-Na carbonates.The emphasis is made on the effect of electrode material on the morphol. of the obtained nanocarbons.Three different materials such as Ni, Cu and NiCu alloy were chosen for anode while galvanized Fe was employed as cathode.The XRD anal. and Raman spectroscopy showed that the produced nanocarborns are in general amorphous.They possess high sp. surface area (SSA) at 400-520 m²/g and high pore volume of 0.8-1.3 cm³/g.The SEM and TEM evidenced that the usage of Ni anode resulted in the development of honeycomb C nanostructures while Cu and NiCu anodes stimulated the growth of unusual scroll-like tubular morphologies which in the case of Cu anode form sea urchin-like assemblies.This is unexpected result since it is not supported by the traditional nucleation growth process of tubules at the applied temperatureA new formation mechanism of such scrolled tubules is proposed where the crucial role is ascribed to CuO nanostructures in the role of templates originating from the corroded anodes.The presence of tubular nanostructures can be the explanation of the higher SSA and pore volume in the samples prepared with Cu and NiCu anodes.Remarkably, the value-added tubular-like C nanostructures can be produced in a low temperature electrolytic CO₂ conversion process even at 500° which at the same time contributes to the reduction of CO₂ footprint.

01 May 2025·Journal of Hazardous Materials

Revealing the enhanced role of hydroxylamine and bimetals in the CuFe2O4/PMS/HA system towards effective degradation of organic contaminants

Article

Author: Ding, Jing ; Wang, Yongxin ; Yan, Hui ; Al-Anazi, Abdulaziz ; Li, Yulong ; Falaras, Polycarpos ; Liu, Fengyang ; Ren, Jiayi ; Wei, Jian ; Zhai, Xuedong

In this study, a hydroxylamine (HA)-enhanced magnetic spinel catalyst CuFe₂O₄-activated peroxymonosulfate (PMS) system (CuFe₂O₄/PMS/HA) was constructed to degrade Sulfamethoxazole (SMX). Results from experiments and theoretical calculations indicated that active species generation mechanism involved the direct activation of PMS by HA, the redox cycles acceleration on the surface of CuFe₂O₄ by HA, and the synergistic action of the low valence Fe and Cu species in CuFe₂O₄ for PMS activation. The efficacy of other organic pollutants removal was further validated in bio-treated landfill leachate through removal performance and toxicity assessment. This study provided an understanding of the role of HA and its interactions with Cu-Fe bimetals to activate PMS, advancing our understanding and inspiring the application of similar spinel/reductants/PMS systems.

100 Deals associated with N.C.S.R. Demokritos

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100 Translational Medicine associated with N.C.S.R. Demokritos

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Pipeline

Pipeline Snapshot as of 11 Jun 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

1

2

Preclinical

Other

1

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

[111In-DOTA]LTT-SS28 ( SSTR2 x SSTR3 x SSTR5 )	Pancreatic Cancer More	Preclinical
CRF receptor antagonists(South Dakota State University) ( CRF receptor )	Adrenal Hyperplasia, Congenital More	Preclinical
CN111936173 ( DAF )	Neoplasms More	Discovery
99mTc-Demogastrin 2 ( CCKB )	Contrast agents More	Pending