Correlation of Memory CD8+ T Cells With Sepsis Severity and Mortality: a Single-center, Unblinded, Prospective, Non-interventional, Observational Study

Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated host response to infection. Severe sepsis is the most common cause of death among critically ill patients in non-coronary intensive care units (ICU). Sustained excessive inflammation and immune dysfunction have been confirmed to play a key role in organ damage and early death of sepsis patients. Therefore, it is important to reduce excessive inflammatory response mediated by immune cells and pro-inflammatory cytokines in the acute phase of sepsis.
Single-cell RNA sequencing performed on both septic patients and mice suggest that changes in Tcm (CD3+ CD8+ CD44+ CD127+ CD62L+) and Tem (CD3+ CD8+ CD44+ CD127+ CD62L -) in the acute phase of sepsis may play an important role in sepsis. In addition, animal researches showed that Tcm and Tem decreased decreased continuously at 24, 48 and 72h after cecal ligation and perforation (CLP) in mice, and the adoptive transfer of Tcm , sorting from spleen of mice 24h after CLP , but not Tem improved 7-day survival rate of sepsis mice.
This observational study is aimed to investigate the quantity and proliferation of Tcm and Tem in the acute phase of sepsis and their correlation with severity level and mortality of septic patients in ICU.

Start Date24 Dec 2024

Sponsor / Collaborator

Wuhan Union Hospital

NCT06653218 / Not yet recruitingNot ApplicableIIT

Efficacy and Safety of Stellate Ganglion Block With Lidocaine Combined Platelet-rich Plasma to Treat Chronic Migraine: a Protocol of a Multi-center, Prospective, Propensity Score-matched, Cohort Analysis

This is a multicenter, prospective, observational, propensity score matching, cohort, and assessor-blinded study designed to compare the effectiveness and safety of lidocaine combined Platelet-rich plasma (PRP) acting on SGB versus lidocaine alone acting on SGB in patients with CM.

Start Date01 Dec 2024

Sponsor / Collaborator

Beijing Tiantan Hospital

[+2]

NCT06654011 / Not yet recruitingPhase 2IIT

IN10018 Plus Nab-Paclitaxel and Cadonilimab for Metastatic, Recurrent, or Persistent Gastric-Type Adenocarcinoma of the Cervix: a Multicenter, Single-Arm, Phase II Trial

Gastric-type adenocarcinoma of the cervix is the most commonly diagnosed HPV-independent subtype of cervical cancer, characterized by a poor prognosis and limited responsiveness to existing therapies. Therefore, the exploration of new treatment modalities is critically important. This is an open-label, single-arm, multi-center clinical trial to evaluate the efficacy and safety of IN10018 plus nab-paclitaxel and cadonilimab in the treatment of adult women with metastatic, recurrent, or persistent gastric-type adenocarcinoma of the cervix.

Start Date01 Nov 2024

Sponsor / Collaborator

Wuhan Union Hospital

100 Clinical Results associated with Wuhan Union Hospital

0 Patents (Medical) associated with Wuhan Union Hospital

Literatures (Medical) associated with Wuhan Union Hospital

01 Jun 2024·Journal of Clinical Oncology

Efficacy and safety of aumolertinib combined with or without chemotherapy as an adjuvant treatment for stage II-IIIA non-small cell lung cancer following complete tumour resection: The first third-generation EGFR-TKI versus chemotherapy phase III clinical study (APEX).

Author: Feng, Gang ; Wang, Sihua ; Wang, Zhijie ; Sun, Daqiang ; Jiang, Tao ; Peng, Hao ; Xu, Shun ; Wu, Qingchen ; Li, Hecheng ; Wang, Jie ; Zhang, Quanren ; Shen, Weiyu ; Zhu, Yuming ; Hu, Weidong ; Liu, Hongxu ; Liu, Wei ; Tan, Feng ; Ma, Haitao ; Gao, Shugeng ; Han, Yongtao

TPS8117 Background: Patients with stage II-III A non-small cell lung cancer (NSCLC) can benefit from adjuvant targeted therapy. ADAURA study shows a remarkable advantage of disease-free survival (DFS). However, there are still unresolved clinical issues. Firstly, the control group in the trial is received placebo, making it impossible to directly compare the efficacy of adjuvant targeted therapy with the traditionally recommended adjuvant chemotherapy in guidelines. Thus, it cannot address the direct comparison of third-generation TKIs with the current standard therapy (chemotherapy). Secondly, the necessity of combining chemotherapy with adjuvant targeted therapy need to explored. Aumolertinib is a third-generation epidermal growth factor receptor- tyrosine kinase inhibitor (EGFR-TKI) that potently and selectively inhibits EGFR sensitizing and EGFR T790M resistance mutations. This study aims to evaluate the efficacy and safety of aumolertinib combined with or without chemotherapy as adjuvant treatment for EGFR-sensitive mutations stage II-III A non-squamous NSCLC patients. Methods: This is a multicenter, randomized, open label, phase III study. Patients with histologically confirmed stage II-III A non-squamous NSCLC harboring EGFR mutations without prior EGFR TKI treatment and R0 resection are eligible for this study. The performance status (Eastern Cooperative Oncology Group) is 0 or 1. This trial prepared to enroll approximately 606 patients, will be randomized (3:2:1) to receive either aumolertinib alone (110mg, po, once daily) or aumolertinib (110mg, po, once daily) plus pemetrexed (500mg/m2, iv) and cisplatin (500mg/m2, iv) or pemetrexed (500mg/m2, iv) plus cisplatin (500mg/m2, iv). The first patient was enrolled on August 2, 2021. The primary end point is DFS, The secondary endpoints include 2, 3, 4, 5-year DFS rates, 5-year overall survival (OS), OS, safety and quality of life. Adverse effects were graded per CTCAE v.4.0. This trial is registered as NCT04762459. Clinical trial information: NCT04762459 .

01 May 2024·Molecular Nutrition & Food Research

Association of Ultraprocessed Food Consumption with Risk of Cardiovascular Disease Among Individuals with Type 2 Diabetes: Findings from the UK Biobank

Article

Author: Geng, Tingting ; Lai, Yuwei ; Liao, Yun‐Fei ; Pan, An ; Tu, Zhou‐Zheng ; Yang, Kun ; Chen, Jun‐Xiang ; Xia, Peng‐Fei ; Liu, Gang ; Li, Yue

ScopeAmong patients with diabetes, who have modified nutritional behavior and a higher risk of cardiovascular disease (CVD), the influence of ultraprocessed foods (UPFs) on CVD remains unknown. The study aims to evaluate the association between UPF intake and the risk of CVD among individuals with type 2 diabetes (T2D) and further examine the potential biological pathways linking the association.Methods and resultsThis study includes 5405 participants with T2D who provided at least one 24‐h dietary recall from the UK Biobank study. In the fully adjusted models, a 10% increase in the proportion of UPFs is associated with higher hazards of overall CVD (hazard ratio [HR]: 1.10; 95% confidence interval [CI]: 1.04, 1.15), coronary heart disease (HR: 1.10; 95% CI: 1.04, 1.16), heart failure (HR: 1.14; 95% CI: 1.05, 1.25), but not stroke (HR: 1.01; 95% CI: 0.90, 1.12). Cystatin C, high‐density lipoprotein cholesterol (HDL‐C), apolipoprotein A, C‐reactive protein, and body mass index collectively explain 26.9% (12.8%, 48.5%) of the association between UPF intake and the risk of overall CVD.ConclusionHigher UPF intakes are associated with increased hazards of CVD among individuals with T2D, and the association is partly mediated through worsening biomarkers of renal function, lipid metabolism, inflammation, and body weight.

05 Apr 2024·Cancer Research

Abstract CT055: Efficacy of YK-029A, a novel EGFR TKI, in advanced NSCLC patients with acquired T790M mutation

Author: Wang, Jie ; Chen, Bi ; Pan, Yueyin ; Duan, Jianchun ; Yao, Yu ; Yang, Yixuan ; Guo, Yongqi ; Yang, Kunyu ; Zhao, Yanqiu ; Wu, Lin ; Zhao, Jun ; Zhang, Zhihong ; Xie, Yanyan ; Liu, Zhe ; Chau, Yi Fung ; Zhao, Mingfang ; Wan, Rui ; Dai, Xiumei

AbstractIn the multicenter, dose-escalation and dose-expansion phase 1 clinical trial (NCT05767866), we evaluated safety and tolerability of YK-029A in various EGFR mutated non-small-cell lung cancer (NSCLC). We have reported efficacy of YK-029A in untreated NSCLC with EGFR ex20ins mutation[1]. This time we report efficacy of YK-029A in patients with acquired EGFR T790M mutation after failure of first or second generation EGFR tyrosine kinase inhibitors (TKIs).Method: This dose-escalation and dose-expansion phase 1 trial recruited previously treated NSCLC patients with EGFR T790M mutation or patients with EGFR ex20ins or EGFR rare mutations. In dose-escalation phase, patients with EGFR T790M mutation were enrolled. YK-029A was given at doses of 50, 100, 150, 200 to 250 mg/day (3+3 design). In dose-expansion phase, patients with EGFR T790M, EGFR ex20ins, or EGFR rare mutations were enrolled. The primary objective was safety. Dose-limiting toxicity (DLT) and maximum tolerated dose (MTD) were explored. Efficacy of YK-029A in EGFR T790M mutated NSCLC was assessed by the investigators.Results: A total of 114 patients were recruited into the study. Safety profile of the first 108 patients was reported previously[1]. By the cut-off date on Sep 12, 2023, 38 patients harbored EGFR T790M mutation were included in efficacy analysis. All these patients were previously treated with first or second generation EGFR-TKIs. The objective response rate (ORR; RECIST 1.1) was 65.8% (95%CI: 48.6%-80.4%) and disease control rate (DCR) was 84.2% (95%CI: 68.7%-94.0%). With a median follow-up time of 8.2 months,the median progression free survival (PFS) was 11.0 months (95%CI: 7.75-NR). The median overall survival (OS) was not reached. Among the 8 patients with measurable brain metastases, intracranial ORR was 75% (95%CI: 35.6%-95.6%) .Conclusions: YK-029A has promising activity in previously treated NSCLC patients harboring EGFR T790M mutation.Reference[1] DUAN J, WU L, YANG K, et al. Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of YK-029A in Treatment-Naive Patients With Advanced NSCLC Harboring EGFR Exon 20 Insertion Mutations: A Phase 1 Trial [J]. J Thorac Oncol, 2023.Citation Format: Rui Wan, Yi Fung Chau, Jun Zhao, Zhe Liu, Mingfang Zhao, Yanqiu Zhao, Xiumei Dai, Yueyin Pan, Zhihong Zhang, Yu Yao, Kunyu Yang, Lin Wu, Yanyan Xie, Bi Chen, Yixuan Yang, Yongqi Guo, Jie Wang, Jianchun Duan. Efficacy of YK-029A, a novel EGFR TKI, in advanced NSCLC patients with acquired T790M mutation [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 2 (Late-Breaking, Clinical Trial, and Invited Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(7_Suppl):Abstract nr CT055.

News (Medical) associated with Wuhan Union Hospital

16 Jan 2023

·www.biospace.com

Medtech Innovator magAssist Inc. Gains Recognition for Its Innovation in the Cardiovascular Field at 2022 Critical Heart Disease Congress-International Society for Mechanical Circulatory Support Parallel Forum

SUZHOU, China, Jan. 16, 2023 /PRNewswire/ -- magAssist Inc. ("magAssist"), a leading global developer of extracorporeal life support devices, attended the 2022 Critical Heart Disease Congress - International Society for Mechanical Circulatory Support Parallel Forum, where the firm shared the latest research results and technologies for the treatment of critical heart diseases with fellow cardiovascular researchers and experts, demonstrating its commitment to innovation and development in the field. The forum was jointly held by 2022 CHDC and ISMCS (International Society for Mechanical Circulatory Support) between December 29 – 31, 2022. The mission of the ISMCS is "provide a broad international forum for intensive discussion of research, development, clinical use and social acceptance of rotary blood pumps and all related forms of mechanical circulatory support". Dr. Hsu Po-Lin, the founder of magAssist and the Chinese board member of ISMCS, co-chaired the session with Dr. Antonio Loforte, President-elect ISMCS and Mechanical Circulatory Support Program Chair from S. Orsola Bologna Cardiothorac & Transplant Surgery and alongside several other cardiovascular experts from around the world. During the session, Dr. Hsu Chia-Hao, Director of Science and Innovation at magAssist, gave a presentation introducing BreathMoAssist™, the next generation of portable extracorporeal membrane oxygenation system developed by magAssist. There is currently a strong clinical demand for ECMO in China. However, there are very limited Chinese-made ECMO devices available for clinical use, creating a gap between the huge clinical demand and the availability of Chinese-made products. Featuring an integrated and portable modular design, weighing overall less than 10 kg, BreathMoAssist™ is easy for doctors to transport the equipment to the patient in need, reducing waiting time and increasing the success rate of treatment. The pump head uses magAssist's full magnetic levitation bearing technology, which has better hemocompatibility than mechanical bearings and can effectively reduce the formation of blood clots when used with artificial membrane lungs. "magAssist tends to develop portable and intelligent ECMO systems," said Chia-Hao. 'magAssist's technology blueprint focuses on an intelligent, interconnected, platform-based solution for the treatment of multi-organ failure. magAssist will keep achieving effective synergy for multi-organ support, enhance therapeutic efficacy and reduce care costs through real-time state monitoring, resulting in the saving of more patients." Prof. Dong Nianguo from Wuhan Union Hospital of China, then shared his clinical experience with the MoyoAssist extracorporeal ventricular assist system, which was jointly developed by Wuhan Union Hospital and magAssist. Wuhan Union Hospital of China is the first to connect the extracorporeal magnetically-levitated artificial heart through the jugular vein and the axillary artery in a minimally invasive approach to minimize patient harm. The procedure deploys a minimally invasive technique and enables upper-body cannulation without affecting the patient's lower limb movement. Patients on Extra-VAD can eat on their own and get out of bed, actions which help them recover and more comfortably await heart transplantation. Up to Dec 28th 2022, MoyoAssist® Extra-VAD has been in clinical trials at 12 centers across China, with 37 patients enrolled for between 3 and 14 days. It has enabled left ventricular, right ventricular and biventricular assistance for different patients, and helps them transition to heart transplantation or other treatment. More than half of the patients at Wuhan Union Hospital were connected with MoyoAssist® Extra-VAD using minimally invasive procedures. The overall patient survival rate was 94.5%, which is satisfactory. To conclude the forum, Loforte mentioned that the congress brings together people from different professions, such as physicians, engineers and technicians, and emphasized the importance of these professionals working together to provide the best possible outcome for patients. In the aftermath of the forum and looking ahead to 2023, magAssist will continue to innovate in the cardiovascular field, and embody the mission of ISMCS: to save lives and improve the quality of life for patients around the world. Note: The forum invited several senior researchers and corporate executives from abroad who spoke about a range of issues in the cardiovascular field, including Dr. Daniel Timms, CEO of BiVACOR Inc., Dr. Ina Laura Perkins, CEO of Scandinavian Real Heart AB, Dr. Shaun Gregory, Associate Professor at Department of Mechanical and Aerospace Engineering, Monash University, Thomas Schlöglhoferh, Biomedical Engineer of Center for Medical Physics and Biomedical Engineering and Department of Cardiac Surgery, Medical University of Vienna, Austria. Prof. Ashraf William Khir, Professor of Cardiovascular Mechanics at Durham University, and Dr. Xinli Du's team from the Brunel Institute for Bio-engineering. Please refer to the congress link for session replays: ISMCS Official Website: magAssist Website: View original content to download multimedia: SOURCE magAssist Inc.

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Pipeline Snapshot as of 22 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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Drug(Targets)	Indications	Global Highest Phase

CD19&CD20 bispecific CAR-T cells(Wuhan Union Hospital) ( CD19 x CD20 )	B lymphoblastic leukemia lymphoma More	Phase 2 Clinical
Umbilical cord derived mesenchymal stem cells(Wuhan Union Hospital)	Anemia More	Phase 2 Clinical
Nanobody-based biepitope BCMA-targeting CAR-T cells(Wuhan Union Hospital) ( BCMA )	Multiple Myeloma More	Phase 2 Clinical
Umbilical Cord Derived Mesenchymal Stem Cells Exosomes(Wuhan Union Hospital)	Neutropenia More	Phase 1
Anti-BCMA anti-CD38 bispecific chimeric antigen receptor T cell therapy(Shengyan Pharmaceutical Technology) ( BCMA x CD38 )	Multiple Myeloma More	Phase 1

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