A randomized, double-blind, placebo controlled, parallel group clinical study for the comparative evaluation of efficacy and tolerability of lutein and zeaxanthin (XanMax2002) in adult subjects with mild cognitive impairment (MCI) - NIL

Start Date05 Aug 2024

Sponsor / Collaborator

Katra Phytochem (India) Pvt Ltd.

CTRI/2019/08/020761 / CompletedPhase 3

A randomized, double-blind, placebo-controlled study to investigate the effects of XanMaxÂ® 80 Crystals with Rosemary extract powder in capsules on skin health attributes (UV and moisturizing parameters)

Start Date26 Aug 2019

Sponsor / Collaborator

Katra Phytochem (India) Pvt Ltd.

CTRI/2019/01/017209 / Not yet recruitingPhase 4

â??A Prospective, Placebo Controlled Study on Carimax Tablet in Management of Chemotherapy induced Thrombocytopenia in solid tumorsâ??

Start Date25 Jan 2019

Sponsor / Collaborator

Katra Phytochem (India) Pvt Ltd.

100 Clinical Results associated with Katra Phytochem (India) Pvt Ltd.

0 Patents (Medical) associated with Katra Phytochem (India) Pvt Ltd.

Literatures (Medical) associated with Katra Phytochem (India) Pvt Ltd.

31 Dec 2021·Preventive Nutrition and Food Science

Pre-Clinical Evaluation of Proprietary Lutein, Zeaxanthin, and Rosemary Formulation for Its Dermal Protective Activity in Male Swiss Albino Mice

Article

Author: Jung, Hyunmook ; Eun, Sangwon ; Heo, Huijin ; Lee, Hana ; Madhavan, Jayashree

This study aimed to evaluate the efficacy of the proprietary lutein, zeaxanthin, and rosemary formulation for its dermal protection against ultraviolet (UV) irradiated skin dehydration. A total of 48 male Swiss albino mice of 8∼12 weeks of age were divided into eight groups of 6 mice: mice in group 1 (G1) were considered the normal control, without treatment and without skin shaving; mice in G2 had their skins were shaved, but did not receive treatment; mice in G3 were the pathological control; mice in G4 were treated as standard (hyaluronic acid); mice in G5∼G8 were treated with low and high doses of 2 different test substances, respectively. Mice were anaesthetized and then depilatory was applied on the dorsal skin area (2 cm×2 cm) on alternate days, then UV/blue light irradiation was carried out for 15 min for 6 weeks. Collagen type 1 gene expression was determined via densitometric analysis, skin elasticity was assessed, and stratum corneum water contents were measured using a cutometer and corneometer. Skin hydration was assessed through transepidermal water loss, and several serum biochemical parameters (collagenase, hydroxyproline, hyaluronic acid, and ceramide levels) were determined to assess the skin moisturizing activity of the product. Images for assessing photoaging were considered between different groups on day 42. All these subjective parameters reached statistical significance (P<0.05) in groups treated with the proprietary lutein and rosemary formulation compared with the placebo-treated group. In conclusion, the proprietary lutein, zeaxanthin, and rosemary formulation showed better protection of skin subjected to UV irradiated skin dehydration.

01 Mar 2021·Biomedicine & PharmacotherapyQ2 · MEDICINE

Protective effect of a mixture of marigold and rosemary extracts on UV-induced photoaging in mice

Q2 · MEDICINE

Article

Author: Auh, Joong-Hyuck ; Madhavan, Jayashree

UV irradiation exposure may induce photoaging of the skin tissue. Various plant extracts have been recognized as effective protectants against UV-induced damage. Here, a mixture of marigold and rosemary extracts was evaluated for its anti-photoaging effects as a potential nutraceutical product for skin health. Hexane extract of marigold and ethanolic extract of rosemary were prepared, and the formulated mixture was investigated. A UV-induced photoaged mouse model was prepared, and the protective effects of the extract mixture were compared with those of hyaluronic acid (positive control). Expression of various photoaging-related biomarkers such as matrix metalloproteinases (MMPs), interleukins, tumor necrosis factor-alpha, procollagen type I, 8-hydroxy-deoxyguanosine, superoxide dismutase, glutathione peroxidase, and catalase were determined. UV irradiation significantly enhanced the expression of these biomarkers through an inflammatory response, however, the mixture of marigold and rosemary extracts exerted inhibitory effects and protected from UV-induced damage. Suppression of inflammatory response were the mechanisms underlying this protective function of the mixture of marigold and rosemary extracts. Histological evaluation also supported these protective effects against photoaging.

100 Deals associated with Katra Phytochem (India) Pvt Ltd.

100 Translational Medicine associated with Katra Phytochem (India) Pvt Ltd.

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