Delving into the Latest Updates on Zhejiang Gongshang University with Synapse

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Immune System Diseases

Recombinant polypeptide

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Disease Domain	Count

Immune System Diseases	1

Top 5 Drug Type	Count

Recombinant polypeptide	1

Top 5 Target	Count

Tropomyosin	1

In this study, we hypothesize that flavor compounds, volatile as well as non-volatile, can be transferred from the oral cavity to the nasal cavity in the form of aerosol particles.To test the potential of aerosol as the carrier of flavor compounds during a drinking process, the aerosol particles of sweetener solutions (sucrose or rebaudioside A) have been quantified at both the in situ and simulated conditions, with or without saliva mixing.As observed by an optical particle counter, shaking or splashing of test samples can generate huge numbers (1000-10000) of aerosol particles with most of them smaller than 1 μm.It was further observed that addition of sucrose, rebaudioside A, saliva, thickener (konjac glucomannan) and defoamer (simethicone emulsion) can significantly alter the generated aerosol particles of water both in situ and in vitro.As estimated by the intensity of fluorescence, the amount of transferred mass within the in vitro prepared aerosol can be 4.9 μg/min.The shear viscosities, surface tension, extensional break time and relaxation time were found to correlate with the aerosol generation of test sample.These results suggest that aerosol particles have the potential in carrying substantial amount of flavor compounds during oral processing, and their generation can be sensitively affected by the presence of food components and saliva.

01 Feb 2025·Separation and Purification Technology

Synergistic mechanisms for efficient and safe antibiotic removal: Effective adsorption and photocatalytic degradation using aerogels

Author: Wang, Peng ; Fang, Kui ; jiang, Xiaojia ; Zhu, Huayue ; Wang, Qi ; Li, Jun ; Li, Qiang ; Deng, Hao ; Wu, Yanling ; Li, Leyi ; Hao, Derek

To tackle the issues of low adsorption capacity, poor regeneration efficiency, and limited recoverability in wastewater treatment adsorbents, we innovatively developed a low-cost Fe(III)-SA gel ball aerogel (FA) through a simple chem. crosslinking method.FA aerogel exhibits exceptional adsorption performance for a wide range of antibiotics, including norfloxacin (NOR), ciprofloxacin (CIP), and tetracycline hydrochloride (TC), showcasing its broad applicability.Remarkably, FA achieved a maximum NOR adsorption capacity of 338.4 mg/g (Langmuir isotherm model, pH 7.0, 298 K, m/V=0.1 g/L).Furthermore, under the synergistic effect of photocatalysis, FA demonstrated a breakthrough by removing 97 % of NOR (30 mg/L, 50 mL) within just 150 min.Notably, FA displayed innovative regeneration capabilities, successfully completing 10 continuous and stable NOR removal cycles without loss of performance.The DFT calculations alongside exptl. evidence were employed to elucidate the NOR degradation pathway, while electron d. distribution and Fukui function anal. confirming the proposed degradation pathways through HPLC-MS results.Moreover, plant stress and zone of inhibition tests verified that the degradation intermediates were significantly less toxic, ensuring the safety of the regeneration process.This research introduces an innovative approach for designing superior adsorbents and provides critical insights into efficient and sustainable adsorbent regeneration.

01 Jan 2025·Separation and Purification Technology

The insights into facet-dependent catalytic performance of Cu2O in peroxymonosulfate activation for effective degradation of antibiotics

Author: Wang, Yudi ; Luo, Jiajia ; Luan, Shuting ; Wang, Jin ; Shao, Yifan ; Pan, Jialu ; Cong, Yanqing ; Lv, Shi-Wen

It was of great significance to improve the performance of catalysts in peroxymonosulfate (PMS) activation for water pollution control.Herein, Cu₂O-based catalysts with different exposed facets were synthesized by a feasible method, and later employed for activating PMS to conduct the degradation tests of tetracycline (TC).With the increase of exposed (1 0 0) facet, the sp. surface area of Cu₂O was improved and the interface charge transfer resistance was reduced.More interestingly, benefiting from the exposure of (1 0 0) facet, the electron-donating ability of Cu₂O was boosted, and the adsorption energy of PMS over Cu₂O was also reduced, thereby creating favorable conditions for PMS activation.As guessed, Cu₂O-1 with (1 0 0) facet can quickly activate PMS to achieve the effective degradation of TC, and the highest removal efficiency of TC over Cu₂O-1 can be up to 97.56 % within 15 min.Furthermore, Cu₂O-1 with good anti-interference showed satisfactory reusability, and the degradation intermediates of TC were the low toxic or nontoxic.In the Cu₂O-1/PMS system, various reactive oxygen species were detected, including SO^•-₄, OH^•, O^•-₂ and ¹O₂, and wherein the contribution of ¹O₂ to TC degradation was the greatest.In short, current work shared some valuable insights into persulfate-based advanced oxidation processes.

100 Deals associated with Zhejiang Gongshang University

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100 Translational Medicine associated with Zhejiang Gongshang University

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Pipeline

Pipeline Snapshot as of 19 Dec 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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