Multicenter, randomized, blind, position-controlled trial on the efficacy and safety of polycaprolactone for injection in the correction of moderate and severe nasolabial wrinkles

Start Date16 Mar 2022

Sponsor / Collaborator

Yanbian University Hospital

ChiCTR2400091004 / CompletedEarly Phase 1

Clinical study on sequential sedation with remimazolam benzenesulfonate combined with propofol in ICU patients undergoing mechanical ventilation

Start Date11 Nov 2021

Sponsor / Collaborator

Yanbian University Hospital

ChiCTR2100045112 / RecruitingPhase 2

Tirelizumab combined with amlotinib for second-line treatment of advanced urothelial carcinoma II Phase II clinical study

Start Date01 Apr 2021

Sponsor / Collaborator

Yanbian University Hospital

100 Clinical Results associated with Yanbian University Hospital

0 Patents (Medical) associated with Yanbian University Hospital

1,196

Literatures (Medical) associated with Yanbian University Hospital

01 Dec 2024·Cellular and Molecular Life Sciences

Cathepsin K deficiency prevented stress-related thrombosis in a mouse FeCl3 model

Article

Author: Meng, Xiangkun ; Yue, Xueling ; Umegaki, Hiroyuki ; Cheng, Xian Wu ; Narisawa, Megumi ; Wan, Ying ; Lei, Yanna ; Hu, Lina ; Murohara, Toyoaki ; Shi, Guo-Ping ; Jin, Xueying ; Kuzuya, Masafumi ; Huang, Zhe ; Xu, Shengnan ; Wu, Yuna ; Inoue, Aiko

AbstractBackgroundExposure to chronic psychological stress (CPS) is a risk factor for thrombotic cardiocerebrovascular diseases (CCVDs). The expression and activity of the cysteine cathepsin K (CTSK) are upregulated in stressed cardiovascular tissues, and we investigated whether CTSK is involved in chronic stress-related thrombosis, focusing on stress serum-induced endothelial apoptosis.Methods and resultsEight-week-old wild-type male mice (CTSK+/+) randomly divided to non-stress and 3-week restraint stress groups received a left carotid artery iron chloride3 (FeCl3)-induced thrombosis injury for biological and morphological evaluations at specific timepoints. On day 21 post-stress/injury, the stress had enhanced the arterial thrombi weights and lengths, in addition to harmful alterations of plasma ADAMTS13, von Willebrand factor, and plasminogen activation inhibitor-1, plus injured-artery endothelial loss and CTSK protein/mRNA expression. The stressed CTSK+/+ mice had increased levels of injured arterial cleaved Notch1, Hes1, cleaved caspase8, matrix metalloproteinase-9/-2, angiotensin type 1 receptor, galactin3, p16IN4A, p22phox, gp91phox, intracellular adhesion molecule-1, TNF-α, MCP-1, and TLR-4 proteins and/or genes. Pharmacological and genetic inhibitions of CTSK ameliorated the stress-induced thrombus formation and the observed molecular and morphological changes. In cultured HUVECs, CTSK overexpression and silencing respectively increased and mitigated stressed-serum- and H2O2-induced apoptosis associated with apoptosis-related protein changes. Recombinant human CTSK degraded γ-secretase substrate in a dose-dependent manor and activated Notch1 and Hes1 expression upregulation.ConclusionsCTSK appeared to contribute to stress-related thrombosis in mice subjected to FeCl3 stress, possibly via the modulation of vascular inflammation, oxidative production and apoptosis, suggesting that CTSK could be an effective therapeutic target for CPS-related thrombotic events in patients with CCVDs.

01 Dec 2024·Journal of Pharmaceutical and Biomedical Analysis

Simultaneous determination of free DL-amino acids in human hair with a novel DBD-M-Pro derivatization by UHPLC-HRMS: An application in diabetes patients

Article

Author: Nan, Jun ; Zhou, Xin ; Wang, Songze ; Cheng, Shengyu ; Wang, Xin ; Li, Xi-Ling ; Min, Jun Zhe

Human hair is a non-invasive biological sample that is easy to collect and store and can reflect long-term body health. However, the correlation between DL-amino acids and metabolic diseases in hair samples has not been studied. Therefore, we propose a novel UHPLC-HRMS method for analyzing seven free chiral amino acids (DL-Thr, DL-Glu, DL-Ala, DL-Val, DL-Pro, DL-Leu, and DL-Phe) simultaneously in hair samples by derivatization of chiral probe 4-(N,N-dmethylaminosulfonyl)-2,1,3-benzoxadiazole-trans-2-methyl-L-proline (DBD-M-Pro) labeled with targeted amino functional groups. Gradient elution was carried out using an ACQUITYTM BEH C18 (100×2.1 mm,1.7 μm) column with a mobile phase of 0.15 % formic acid (FA) in 10 mM ammonium acetate (CH₃-COONH₄) and 0.2 % FA in acetonitrile. The labelled DL-amino acid diastereoisomers could be completely separated, with a resolution (Rs) of 1.59-11.44. These amino acids show a strong linear correlation within the range of 3.1-99.2 pmol (R² ≥ 0.9990). Intraday and interday precision was 1.87 %-14.87 %. The average recovery was 96.12 %-105.33 %. The limit of detection (LOD) ranged from 0.29 to 2.11 pmol. We then employed the method to determine the concentration of free chiral amino acids in hair samples from 30 healthy volunteers (HVs) and 30 diabetes patients (DPs). Male diabetes patients had significantly higher levels of L-Thr, L-Val, L-Leu (p < 0.05), and D-Ala (p < 0.01) in their hair samples than male healthy volunteers and female diabetes patients had significantly higher levels of D-Ala (p < 0.05) in their hair samples than female healthy volunteers. This is the first study to confirm the feasibility of using free DL-amino acids in human hair as potential biomarkers for diabetes.

01 Nov 2024·Histology and histopathology

NCAPD3 is a prognostic biomarker and is correlated with immune infiltrates in glioma.

Article

Author: Lu, Xin ; Zhao, Jingyu ; Ren, Zijun ; Liu, Qian ; Che, Huiying ; Guan, Hongjian ; Wu, Yu ; Qu, Linzhuo

Non-SMC Condensin II Complex Subunit D3 (NCAPD3) has been linked with the genesis and progression of multiple human cancers. Nevertheless, the scientific value and molecular process of NCAPD3 in glioma remain unclear. We explored the level of NCAPD3 expression in pan-cancer by multiple online databases. And we focused on the level and prognostic value of NCAPD3 expression in glioma by immunohistochemistry (IHC) and survival analysis. Meanwhile, we verified the relationship between NCAPD3, biological function and immune infiltration in glioma by Linkedomics and SangerBox databases. The expression of NCAPD3 was increased in a variety of cancers, including glioma. Its high expression was strongly related to WHO grade (P=0.002) and programmed cell death ligand 1 (PD-L1) expression of glioma (P=0.001). Patients with a high level of NCAPD3 expression had a lower overall survival (OS) in glioma than patients with a low level of NCAPD3 expression. Multivariate statistical analyses showed NCAPD3 expression (P=0.040), WHO grade (P<0.001), 1p/19q codeletion (P<0.001), recurrence (P<0.001), age (P=0.023), and chemotherapy status (P=0.001) were meaningful independent prognostic factors in patients with glioma. Furthermore, bioinformatics analysis proved that NCAPD3 has been linked to immune infiltration in glioma. High level of NCAPD3 expression may serve as a promising prognostic biomarker and correlate with dendritic cell infiltration, representing a potential immunotherapy target in glioma.

100 Deals associated with Yanbian University Hospital

100 Translational Medicine associated with Yanbian University Hospital

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