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Immune System Diseases

Respiratory Diseases

Hemic and Lymphatic Diseases

Synthetic peptide vaccine

Small molecule drug

Dendritic cell vaccine

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Immune System Diseases	2
Hemic and Lymphatic Diseases	1
Neoplasms	1

Top 5 Drug Type	Count

Dendritic cell vaccine	1
Small molecule drug	1
Synthetic peptide vaccine	1

Top 5 Target	Count

RHOA(ras homolog family member A)	1

The budding of human immunodeficiency virus from an infected host cell is induced by the modification of structural proteins bearing long-chain fatty acids, followed by their anchoring to the cell membrane. Although many model budding systems using giant unilamellar vesicles (GUVs) induced by various stimuli have been developed, constructing an artificial viral budding system of GUVs using only synthesized molecules remains challenging. Herein, we report the construction of an artificial viral capsid budding system from a lipid bilayer of GUV. The C-terminus of the β-annulus peptide was modified using an octyl chain as an alkyl anchor via a disulfide bond. The self-assembly of the β-annulus peptide with an octyl chain formed an artificial viral capsid aggregate. The fluorescence imaging and transmission electron microscopy observations revealed that the addition of the tetramethylrhodamine (TMR)-labeled octyl chain-bearing β-annulus peptide to the outer aqueous phase of GUV induced the budding of the capsid-encapsulated daughter vesicle outside-to-inside the mother GUV. Conversely, the encapsulation of the TMR-labeled octyl chain-bearing β-annulus peptide in the inner aqueous phase of GUV induced the budding of the capsid-encapsulated daughter vesicle inside-to-outside the mother GUV. Contrarily, the addition of the TMR-labeled β-annulus peptide to GUV barely induced budding. It was demonstrated that the higher the membrane fluidity of GUV, the more likely budding would be induced by the addition of the alkyl anchor-modified artificial viral capsid. The simple virus-mimicking material developed in this study, which buds off through membrane anchoring, can provide physicochemical insights into the mechanisms of natural viral budding from cells.

31 Dec 2024·SICE Journal of Control, Measurement, and System Integration

Usefulness of hand sensor device for lumbar load estimation

Author: Kushida, Daisuke ; Kinoshita, Dai ; Kamezaki, Takashi ; Yoshida, Yusuke

31 Dec 2024·Cogent Economics & Finance

Comparative analysis of household food security and its determinants among Productive Safety Net Program (PSNP) beneficiary, graduated, and non-beneficiary in Northwestern Ethiopia

Author: Yasunobu, Kumi ; Elias, Asres ; Endalew, Birara ; Merkeb, Yednekachew

100 Deals associated with Tottori University

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100 Translational Medicine associated with Tottori University

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Pipeline

Pipeline Snapshot as of 07 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

1

Phase 1 Clinical

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