Delving into the Latest Updates on Zhejiang Provincial Peoples Hospital with Synapse

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Neoplasms

Digestive System Disorders

Endocrinology and Metabolic Disease

Oncolytic virus

Monoclonal antibody

Disease domain score

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Disease Domain	Count

Neoplasms	3
Endocrinology and Metabolic Disease	1

Top 5 Drug Type	Count

Oncolytic virus	2
Monoclonal antibody	1

Top 5 Target	Count

PDL1(Programmed death-ligand 1)	1
IGF2BP3(insulin like growth factor 2 mRNA binding protein 3)	1
SMAC(diablo IAP-binding mitochondrial protein)	1

OBJECTIVESAnalyze the effectiveness of different non-pharmacological sleep interventions in preventing delirium among postoperative ICU patients.RESEARCH METHODOLOGYWe conducted a comprehensive search on PubMed, Cochrane Library, Web of Science, Embase, CINAHL, OpenGrey and reference lists up to May 2024.SETTINGWe systematically searched all randomized controlled trials related to non-pharmacological sleep interventions for the prevention of delirium.RESULTSThe results of the network meta-analysis showed that, compared to Usual Care, multicomponent interventions are the most effective measures for preventing delirium in postoperative ICU patients (RR = 0.32, 95 % CI = 0.20 to 0.51). This is followed by non-pharmacological sleep interventions aimed at stress relief (RR = 0.60, 95 % CI = 0.41 to 0.89) and circadian rhythm (RR = 0.61, 95 % CI = 0.39 to 0.96). Additionally, non-pharmacological sleep interventions focusing on circadian rhythm demonstrated an improvement in sleep quality among postoperative ICU patients (SMD = -0.99, 95 % CI = -1.88 to -0.11).CONCLUSIONSOur study found that multicomponent non-pharmacological sleep interventions are effective in reducing the incidence of delirium in postoperative ICU patients. Furthermore, non-pharmacological interventions focused on circadian rhythm regulation significantly enhance sleep quality among these patients.IMPLICATIONS FOR CLINICAL PRACTICEBased on this study, intensive care units and nursing staff have an opportunity to implement the most effective non-pharmacological sleep interventions to prevent delirium and improve sleep quality in postoperative ICU patients. This could contribute to a reduction in the incidence of delirium in postoperative ICU patients.

01 Apr 2025·Talanta

Nanochannel confined graphene quantum dots/platinum nanoparticles boosts electrochemiluminescence of luminal-O2 system for sensitive immunoassay

Article

Author: Mou, Yiping ; Zhou, Yucheng ; Zhang, Chaoyan ; Liu, Jiyang

Sensitive detection of tumor biomarkers is of great significance for early cancer diagnosis, treatment evaluation, and recurrence monitoring. Development of convenient electrochemiluminescence (ECL) immunosensor using dissolved oxygen (O₂) as an endogenous co-reactant of luminol combined with efficient nanocatalysts to boost ECL signal in neutral media is highly desirable. Herein, sensitive detection of tumor biomarker using ECL of luminal-O₂ enhanced by confinement of nitrogen-doped graphene quantum dots (N-GQDs) and platinum nanoparticles (PtNPs) on nanochannel array was demonstrated. A high-density nanochannel array-modified electrode was achieved by rapidly growing an amino-functionalized. Vertically-ordered mesoporous silica film (NH₂-VMSF) on the inexpensive and readily available indium tin oxide (ITO) electrode. Through simple electrodeposition, N-GQDs were confined and PtNPs were in-situ synthesized in nanochannels of NH₂-VMSF. These confined nanocomposites catalyzed the electroreduction of O₂ at negative potentials to generate a large amount of reactive oxygen species (ROS) and facilitated luminol oxidation, enhancing the ECL signal of luminol by 25 times. Two immunosensors were fabricated after covalent immobilization of the recognition antibody of carbohydrate antigen 199 (CA199) or carbohydrate antigen 125 (CA125) on the outer surface of the NH₂-VMSF and blocking of non-specific sites. When tumor biomarkers bind to the corresponding antibodies on the recognition interface, the formed immunocomplex hindered the diffusion of luminol to the underlying electrode, resulting in a decrease in the ECL signal and sensitive detection of tumor biomarker. The constructed CA199 immunosensor exhibited a linear detection range for CA199 from 0.5 mU mL^-1 to 50 U mL^-1, with a detection limit (DL) of 0.03 mU mL^-1. For CA125 detection, linear detection ranged from 0.5 mU mL^-1 to 500 U mL^-1, with a DL of 0.005 mU mL^-1. The fabricated immunosensors demonstrated good selectivity and high reproducibility. This study provides great potential for the development of efficient luminol ECL systems in neutral media and expands the biological application in sensitive detection of tumor biomarker.

1

News (Medical) associated with Zhejiang Provincial Peoples Hospital

18 Jul 2024

·www.drugs.com

Digital Subtraction Angiography-Guided TDC Performance Superior

THURSDAY, July 18, 2024 -- The performance of digital subtraction angiography (DSA)-guided tunneled dialysis catheters (TDC) is superior to that of ultrasound-guided TDC in renal replacement therapy, according to a study published online July 9 in Renal Failure . Yiwei Shang, from the Zhejiang Provincial People's Hospital in China, and colleagues conducted a retrospective cohort study including all TDC placements performed between January 2020 and October 2022 to compare ultrasound- and DSA-guided TDC in renal replacement therapy. Data were included for 261 patients (142 in the DSA-guided group and 119 in the ultrasound-guided group); after propensity score matching, 91 patients were included in each group. The researchers found that adequate catheter blood flow and ultrafiltration volumes without deviations from dialysis prescriptions were achieved in both groups (intraclass correlation coefficients ≥0.75). Fewer early dialysis terminations were seen in the DSA- versus the ultrasound-guided group (3.3 versus 12.0 percent). In the DSA-guided group, the position of the catheter tip in the right atrium was more consistent (100 versus 74.2 percent). "This study recommends the use of DSA when the catheter tip cannot be reliably placed in the right atrium," the authors write. Abstract/Full Text Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.

Clinical Result

100 Deals associated with Zhejiang Provincial Peoples Hospital

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100 Translational Medicine associated with Zhejiang Provincial Peoples Hospital

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Pipeline

Pipeline Snapshot as of 27 Jan 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

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Preclinical

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

oVV-Smac ( SMAC )	Pancreatic Cancer More	Preclinical
Mineralized oncolytic adenovirus(Techpool Bio-Pharma) ( PDL1 )	Colorectal Cancer More	Preclinical
CN115746120 ( IGF2BP3 )	Neoplasms More	Discovery