Nanjing Traditional Chinese Medical Hospital

Emerging published data on the association between single nucleotide polymorphisms (SNPs) in the estrogen receptor 1 (ESR1) gene and cancer susceptibility are inconsistent. This review and meta-analysis is performed to derive a more precise evaluation of this relationship.

The literature search of PubMed, Embase, Web of Science and CNKI databases was conducted from their inception through June 2014. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the association.

Twenty-two literatures were enrolled in this meta-analysis. The results indicated that ESR1 rs1801132 (C>G) was associated with cancer risk in Caucasian populations. However, the results of stratified analysis by cancer type and source of controls indicated that no significant association was found. Furthermore, rs2077647 (A>G) was only associated with an increased risk of hepatocellular carcinoma, but was an adverse effect on cancer risk in Caucasian populations.

This present meta-analysis indicated that rs1801132 (C>G) and rs2077647 (A>G) may be protective factors in Caucasian populations. Meanwhile, rs2077647 (A>G) may be closely related with hepatocellular carcinoma.

The serum C-reactive protein (CRP) levels and its clin. significance in Mycoplasma pneumoniae pneumonia (MPP) were observedChildren with 88 cases MPP (MPP group), 75 cases bacterial pneumonia (bacterial group), 53 cases viral pneumonia (virus group) were detected, and 60 cases healthy children as control.By immune turbidimetry method, serum CRP level (the first three groups were measured on admission) in four groups was detected, 8 mg/L as pos.The pos. rate and serum CRP levels in MPP group were significantly higher than the virus and control groups, but significantly lower than the bacterial group, those in systemic inflammatory response syndrome (SIRS) were significantly higher than those with SIRS (P all < 0.05).Serum CRP level in MPP children has characteristic change, which can be used in diagnosis and illness.

Relationship of sucrose content in TCM decocted ointments with d. and quality standard was studied.Sucrose content of polygonatum ointment with different batch number was detected with iodometry, and d. of the ointment was detected.The results showed that sucrose content of polygonatum ointment with different batch number was higher than quality standard by >10%.Changes of ointment d. was not obvious and credible as current online index.It was necessary to detect both d. and sucrose content for quality control.Iodometry was a simple and accurate method to detect sucrose content.