Smart Immune SAS

Smart Immune appoints key new members to its Board of Directors PARIS, France, 16 February 2024 – Smart Immune, a clinical-stage biotechnology company developing ProTcell, a thymus-empowered T cell progenitor therapy platform to fully and rapidly re-arm the immune system against cancers and infections, today announces the appointment of new Board directors, effective immediately. Markus Goebel, Grégoire Cayatte, Federico Mingozzi and Pablo Silveri will join existing directors, Dominique Costantini and Fouzia Laghrissi-Thode, to accelerate and support the growth of Smart Immune. Markus Goebel succeeds Sebastian Lombardo as Chairman of the Board of Directors. Jean-Pierre Bizzari completes the team as an observer. Karine Rossignol, CEO and Co-founder of Smart Immune, said: “We are delighted and proud to welcome such distinguished experts to the Board, led by Markus Goebel as our new Chairman. Their collective expertise will provide invaluable support in our efforts to achieve clinical and economic success, ultimately benefiting patients who need a fully and rapidly re-armed immune system to fight severe cancer and infection. We are grateful to our outgoing Chairman for his 5-year commitment and support to Smart Immune.” Markus Goebel, CEO and Founder of M&G Advisors and Chairman of Smart Immune’s Board of Directors, said: “I am thrilled to join and lead the Board of Smart Immune. The company has attracted significant investment for its thymus-empowered platform, and I am looking forward to working with the team to deliver the potentially life-changing ProTcell-derived therapies to patients.” Markus Goebel spent more than a decade in academia as a hematologist-oncologist before joining the pharmaceutical industry, spanning a 30+ year career. He held key positions at Farmitalia, at Roche, amongst others in collaboration with Amgen, and at Novartis in BD&L and corporate M&A. Between 2004 and 2019, Dr Goebel was Managing Director of the Novartis Venture Fund in the US and Switzerland/Europe, where he served as a director for several investment companies. In 2019, he founded M&G Advisors GmbH, a biotech and medtech consulting company. He has also been appointed as an expert by Innosuisse, the Swiss Innovation Agency. Jean-Pierre Bizzari is a highly experienced oncologist who has been successfully bringing innovative cancer treatments to market for over 35 years, overseeing clinical development in companies including Rhône-Poulenc, Sanofi-Aventis, Celgene, Servier and Halozyme. Dr Bizzari is a member of the Scientific Advisory Board of the French National Cancer Institute and the Board of the European Organization for Research and Treatment of Cancer, as well as serving as the Chairman of its New Drug Committee. He is on the Boards of Halozyme, ADC Therapeutics and Aprea Therapeutics and now an Observer on the Board of Directors at Smart Immune. Grégoire Cayatte is Managing Partner and Co-Founder of TechLife Capital, an independent growth equity fund that specializes in healthcare and tech industries. After spending 5 years in equity transactions at Lazard and Paribas, he became Director of Strategy, Development and Finance at Devoteam, a listed technology services company, where he led more than 50 acquisitions in 20 countries and played a key role in the creation of 7 platforms, notably in cybersecurity, cloud migration and digital transformation. In the healthcare sector, Grégoire is a member of the supervisory boards of Evolutis, Flash Therapeutics, Mitem Pharma, MyData-Trust, Quinten and XPath. He is a graduate of École Polytechnique, École des Ponts ParisTech and SciencesPo Paris. Federico Mingozzi currently serves as the CEO of a US-based biotech company and is a Non-Executive Director of Sensorion’s Board of Directors. Previously, he held the positions of Chief Science Officer and Chief Technology Officer at Spark Therapeutics. Federico's expertise in gene therapy vectors and immune system interactions is widely recognized and he has made significant contributions to the field. His previous positions include the Head of the Immunology and Liver Gene Transfer Unit at Genethon, Research Director at the French National Institute of Health and Medical Research (INSERM) in France, and Director at the Children’s Hospital of Philadelphia. Pablo Silveri is the Chief Finance Officer and Co-founder of Nuqlea, a B2B digital marketplace for construction and habitat, and Smart Immune’s former Chief Financial Officer. Pablo is a corporate finance expert who held managing roles at the Dow Chemical Company, where he worked for 25 years. Before joining Smart Immune in 2019, Pablo was the Latin America Finance Director at Dow. He is also a Board member of the Spanish company, Auravant. About Smart Immune Smart Immune is a clinical-stage French biotechnology company developing ProTcell, a thymus-empowered T cell progenitor platform to fully and rapidly re-arm the immune system against cancer and infection, enabling next-generation allogeneic T cell therapies. The company aims to radically improve outcomes for patients in hematology and immune-oncology. Smart Immune has ongoing collaborations with leading institutions in the US and Europe. SMART101 is in Phase I/II clinical trials in cancer patients with AML and ALL, in SCID in the EU and the US. Smart Immune is also developing therapies using gene-modified T cell progenitors through its ProTcell platform to provide targeted treatments like off-the-shelf CAR T. The Company is headquartered in Paris, France, at Paris Biotech Santé. LinkedIn | X (formerly Twitter) Media contact: ICR Consilium smartimmune@consilium-comms.com Attachment 240216 Smart Immune renforce son Conseil d'administration avec de nouveaux experts de l'industrie DEF

Smart Immune appoints Dr. Rahim Fandi, M.D, PhD as Chief Medical Officer, strengthening C suite with seasoned oncology expertise PARIS, France, 04 December 2023 – Smart Immune, a clinical-stage biotechnology company developing ProTcell, a thymus-empowered T cell progenitor therapy platform to fully and rapidly re-arm the immune system against tumors and infection, today announces the appointment of Dr. Abderrahim (Rahim) Fandi as Chief Medical Officer, effective immediately. Dr Fandi brings more than 25 years of experience of oncology clinical development programs in the pharmaceutical and biotechnology industry. He joins from Oxford Biotherapeutics, where he held the role of Chief Medical Officer and was a member of the Executive Committee, playing a pivotal role in leading all clinical and regulatory aspects of the oncology pipeline and multi-disciplinary teams across two sites. Prior to this, Rahim held senior clinical research and development positions at Celgene, Novartis, Bristol Myers Squibb and AstraZeneca. Dr Fandi started his career at Sanofi Winthrop. Karine Rossignol, Chief Executive Officer of Smart Immune, said: “Rahim’s extensive experience in clinical development to explore new immuno-oncology technologies will be an invaluable asset to Smart Immune. In this role, Rahim will be instrumental in advancing our clinical-stage ProTcell derived product, beyond post transplantation hematology. The applications to improve patients’ prognosis in both hematological and solid tumors indications are very exciting.” Dr. Rahim Fandi M.D, PhD, Chief Medical Officer of Smart Immune, said: “I am excited to be joining the talented Smart Immune team at such a critical juncture in the Company’s development. I look forward to working with the leadership team, board of directors, and the KOLs of the clinical advisory board to help patients with life-threatening diseases to live longer and better. The Phase I/II ReSET-02 trial is recruiting at a very encouraging speed with the goal to define the optimal dose in adults followed by the expansion of the clinical program to other hematological malignancies and solid tumors.” About Smart Immune Smart Immune is a clinical-stage biotechnology company developing ProTcell, a thymus-empowered T cell progenitor therapy platform to fully and rapidly re-arm the immune system against cancer and infection, enabling next-generation allogeneic T cell therapies for all. The company aims to radically improve outcomes for patients with life-threatening diseases such as high-risk blood cancers and primary immunodeficiencies. Smart Immune has ongoing collaborations with leading institutions in the US and Europe. SMART101 is already in Phase I/II clinical trials, in the EU and the US, looking at the acceleration of complete immune recovery in patients fighting cancer and infection and undergoing allogeneic hematopoietic stem cell transplantation. Smart Immune is also developing therapies using gene-modified T cell progenitors through its ProTcell platform to provide targeted treatments against cancer, like persistent off-the-shelf CAR T cells. The Company is headquartered in Paris, France, at Paris Biotech Santé.https://www.smart-immune.com/LinkedIn | X (formerly Twitter) Media contact: ICR Consiliumsmartimmune@consilium-comms.com Attachment Rahim Fandi nomination CMO FRENCH

Smart Immune to host R&D KOL webinar on thymus-empowered ProTcell platform Clinical-stage T-cell progenitor therapy aims to re-arm the immune system against cancer and infection New class of T-cell subtype: T-cell progenitors, combined with the power of the thymus to fully re-arm immune-compromised patients in just three monthsImproves the benefit/risk ratio of allogeneic T-cell medicineBroad applications, including HSCT, CAR-T and beyondWebinar on 28 November 2023 at 5:00pm CET/11.00am EST– register here PARIS, France, 10 November 2023 – Smart Immune, a clinical-stage biotechnology company developing ProTcell, a thymus-empowered T-cell progenitor therapy platform to fully and rapidly re-arm the immune system, invites you to attend an R&D KOL webinar on Tuesday 28 November 2023 from 5.00pm to 6.30pm CET (11.00am to 12.30pm EST). Karine Rossignol, Co-founder and Chief Executive Officer of Smart Immune, will give an introduction to Smart Immune and its ProTcell platform. Robert Soiffer, Chairman of the Center for International Blood and Marrow Transplant Research advisory committee at the Dana-Farber Cancer Institute, and Smart Immune’s Clinical Advisory Board Chairman, will talk about the need to improve allogeneic hematopoietic stem cell transplantation outcomes in daily practice. Marina Cavazzana, Co-founder and Strategic Clinical Development Advisor of Smart Immune, will present the ReSET-01 and ReSET-02 trials, including preliminary results in adult acute leukemia patients. Marcel Van den Brink, President of the City of Hope Los Angles National Medical Center and Chief Physician Executive, and Smart Immune’s Scientific Advisory Board Chairman, will discuss the importance of thymic function in the immune system. Olivier Negre, Chief Scientific Officer of Smart Immune, will outline preclinical data on the regenerative properties of ProTcell and its potential to unlock allogeneic T-cell medicine. A Q&A session will follow the presentations. To register please click here. About Smart Immune Smart Immune is a clinical-stage biotechnology company developing ProTcell, a thymus-empowered T-cell progenitor therapy platform to fully and rapidly re-arm the immune system, enabling next-generation allogeneic T-cell therapies for all. The company aims to radically improve outcomes for patients with life-threatening diseases such as high-risk blood cancers and primary immunodeficiencies. Smart Immune has ongoing collaborations with leading institutions in the US and Europe. SMART101 is already in Phase I/II clinical trials, in the EU and the US, looking at the acceleration of complete immune recovery in patients fighting cancer and infection and undergoing allogeneic hematopoietic stem cell transplantation. Smart Immune is also developing therapies using gene-modified T-cell progenitors through its ProTcell platform to provide targeted treatments against cancer or AIDS, like persistent off-the-shelf CAR T-cells or HIV-resistant T-cells. The company is headquartered in Paris, France, at Paris Biotech Santé. https://www.smart-immune.com/LinkedIn | X (formerly Twitter) Contact: info@smart-immune.com