Guang Dong Wan Tai Ke Chuang Yao Ye You Xian Gong Si

To study the pharmacokinetics of the test preparation ORFT (specification: 5 mg, provided by Guangdong Wantai Kechuang Pharmaceutical Co., Ltd.) and the reference preparation rosuvastatin calcium orodisintegrating tablets (specification: 5 mg, licensee: Astra Zeneca Co., Ltd.) in healthy adult subjects after a single oral administration in the fasting and fed state, and to evaluate the bioequivalence of the two preparations after fasting and fed oral administration. Secondary study objectives To evaluate the safety of the test preparation ORFT and the reference preparation rosuvastatin calcium orodisintegrating tablets after a single oral administration in the fasting and fed state in healthy Chinese subjects.

Main study objectives To study the pharmacokinetics of a single oral dose of the test preparation of cefixime dry suspension (specification: 0.8g (100mg/5ml), provided by Guangdong Wantai Kechuang Pharmaceutical Co., Ltd.) and the reference preparation of cefixime dry suspension (specification: 100mg/5ml, licensee: Sanofi-aventis France) in healthy adult subjects under fasting and fed conditions, and to evaluate the bioequivalence of the two preparations when taken orally on a fasting and fed basis. Secondary study objectives To evaluate the safety of a single oral dose of the test preparation and reference preparation of cefixime dry suspension in healthy Chinese subjects under fasting and fed conditions.

To study the pharmacokinetics of the test preparation cefadroxil dry suspension (specification: 500mg/5mL, manufacturer: Sichuan Saizhuo Pharmaceutical Co., Ltd.) and the reference preparation cefadroxil dry suspension (specification: 500mg/5mL, licensee: LUPIN LTD) in healthy adult subjects after a single oral administration in fasting and fed state, and to evaluate the bioequivalence of the two preparations after fasting and fed oral administration. Secondary study objectives To evaluate the safety of the test preparation cefadroxil dry suspension and the reference preparation cefadroxil dry suspension after a single oral administration in fasting and fed state in healthy Chinese subjects.