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Author: Bhargava, Vinant ; Bhasin, Dinkar ; Prasad, Narayan ; Das, Saurav ; Naik, Nitish ; Patel, Manas Ranjan ; Bhalla, Anil Kumar ; Roy, Debabrata ; Kumar, Dilip ; Dastidar, Dipankar Ghosh ; Varughese, Santosh ; Raju, Sree Bhushan ; Bahl, Ajay ; Bang, Vijay Harikisan ; Ganguly, Kajal ; Bansal, Shyam Bihari ; Rakshit, Sumit ; Roy, Sandipta ; Yadav, Rakesh ; Rathi, Manish ; Sinha, Dhurjati Prasad ; Banerjee, Partha Sarathi ; Trivedi, Mayuri ; Gulati, Sanjeev ; Agstam, Sourabh

Cardiovascular diseases are a major cause of death after kidney transplantation. This statement addresses preoperative cardiac decision-making and management with the aim of assessing and reducing the risk of the kidney transplant surgery. Important issues from a clinician's perspective include the basic cardiovascular workup of these patients, coronary evaluation and management of coronary artery disease, valvular heart disease and left ventricular systolic dysfunction. Recovery left ventricular function after kidney transplant is discussed. In addition, the use of cardiovascular drugs in patients with special emphasis on antiplatelets and anticoagulants in patients planned for kidney transplant is also discussed.

01 Mar 2025·Indian Heart Journal

Genetic testing of cardiomyopathies: Position statement of the Cardiological Society of India

Article

Author: Subramanian, Muthiah ; Naik, Nitish ; Bang, Vijay Harikisan ; Ahamed, Hisham ; Vaidya, Vanya ; Chandra Rath, Pratap ; Dastidar, Dipankar Ghosh ; Bahl, Ajay ; Khullar, Madhu ; Dhandapany, Perundurai S ; Nampoothiri, Sheela ; Rani, Deepa Selvi ; Namboodiri, Narayanan ; Chockalingam, Priya ; Thangaraj, Kumarasamy ; Banerjee, Partha Sarathi ; Sinha, Dhurjati Prasad ; Das, Soumi ; Anantharaman, Rajaram ; Mittal, Anupam ; Seth, Sandeep ; Roy, Debabrata ; Yadav, Rakesh ; Sivasubbu, Sridhar

15 Feb 2025·PARIPEX INDIAN JOURNAL OF RESEARCH

A CASE REPORT ON ADULT TYPE LEYDIG CELL TUMOR OF THE TESTIS WITH ATYPICAL HISTOPATHOLOGICAL FINDINGS: A DIAGNOSTIC CHALLENGE

Author: Das, Krishnendu ; Ballav, Antu ; Das, Soma

Testicular neoplasms fall into two main categories: germ cell tumours sex cord-stromal tumours. The Leydig cells and the Sertoli cells are the two somatic cell types that give rise to sex cord-stromal tumours. Leydig cell tumours of the testis are rare, accounting for 1% to 3% of all testicular neoplasms although they are the most prevalent interstitial neoplasms of the testis2. Though LCTs can happen at any age, they are more common in men between the ages of 30 - 60 years and prepubertal boys, who are typically between the ages of 5 - 10 years7,8. LCTs are always benign in children and malignant in 10% adult cases, accounts for a disease-specific mortality rate 6.6%9,10,11. Benign LCTs are traditionally treated with orchiectomy and malignant LCTs are treated by orchiectomy combined with retroperitoneal lymphadenectomy12. Here, we present a case report on adult type Leydig cell tumor of the testis with atypical histopathological findings: a diagnostic challenge. In our case a 75years old male presented to the OPD with left scrotal swelling. USG showed an ill-defined lesion in left testis. He underwent left high inguinal orchidectomy, gross examination of the specimen showed a 7.5×5×4 cm heterogenous mass in left testis. On microscopical examination of H&E stained section showed monomorphic polygonal cells with eosinophilic cytoplasm arranged in insular pattern having rounded nuclei with granular chromatin and absence of prominent nucleoli. Immunohistochemistry showed the tumor was positive for -inhibin and vimentin and negative for chromogranin A, synaptophysin, SALL-4, OCT3/4. The presence of these atypical histopathological features in our case led to a diagnostic dilemma, which was further overcome by IHC findings. So, this case report and result signifies the importance of IHC for accurate diagnosis and management of the patients with testicular tumor.

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