A Multicenter, Prospective, Randomized Controlled Study Comparing the Efficacy and Safety of CLAG(Cladribine, Cytarabine and G-CSF) Combined With Venetoclax and CLAG in the Treatment of Relapsed/Refractory Acute Myeloid Leukemia

This is a multicenter, prospective, randomized controlled clinical study comparing the efficacy and safety of CLAG+VEN and CLAG regimens in relapsed/refractory(r/r) AML.

Start Date01 Feb 2025

Sponsor / Collaborator

Liuzhou People'S Hospital

[+20]

ChiCTR2500095172

/ SuspendedNot ApplicableIIT

Construction of an Intelligent Perception Model for Multimodal Data of Malignant Tumors

Start Date01 Feb 2025

Sponsor / Collaborator

Liuzhou People'S Hospital

ChiCTR2400094935

/ SuspendedPhase 4IIT

A Study on the Correlation of Prognosis in Patients with Pulmonary Hypertension by Using Viscoelastic Imaging Technology Combined with Multimodal Echocardiography

Start Date01 Jan 2025

Sponsor / Collaborator

Liuzhou People'S Hospital

100 Clinical Results associated with Liuzhou People'S Hospital

0 Patents (Medical) associated with Liuzhou People'S Hospital

397

Literatures (Medical) associated with Liuzhou People'S Hospital

01 Dec 2025·Neural Regeneration Research

Functional abnormalities of the glymphatic system in cognitive disorders

Article

Author: Yan, Sicheng ; Shentu, Wuyue ; Xu, Qi ; Chen, Qiulu ; Wang, Junjun ; Lai, Qilun ; Kong, Qi ; Qiao, Song ; Li, Wenyao ; Zhang, Yier

Various pathological mechanisms represent distinct therapeutic targets for cognitive disorders, but a balance between clearance and production is essential for maintaining the stability of the brain’s internal environment. Thus, the glymphatic system may represent a common pathway by which to address cognitive disorders. Using the established model of the glymphatic system as our foundation, this review disentangles and analyzes the components of its clearance mechanism, including the initial inflow of cerebrospinal fluid, the mixing of cerebrospinal fluid with interstitial fluid, and the outflow of the mixed fluid and the clearance. Each section summarizes evidence from experimental animal models and human studies, highlighting the normal physiological properties of key structures alongside their pathological manifestations in cognitive disorders. The same pathologic manifestations of different cognitive disorders appearing in the glymphatic system and the same upstream influences are main points of interest of this review. We conclude this article by discussing new findings and outlining the limitations identified in current research progress.

01 Jul 2025·Cancer Letters

Comparable survival outcomes in HLA-Matched and haploidentical hematopoietic stem cell transplantation for severe aplastic anemia patients aged 40–50: A CBMTR Registry-based propensity score matching analysis over the last decade

Article

Author: Li, Xin ; Zhang, Jian-Ping ; Zhang, Yu-Ping ; Xu, Ya-Jing ; Wu, Tong ; Wang, Chun ; Xu, Lan-Ping ; Zhang, Xi ; He, Peng-Cheng ; Zhang, Xue-Jun ; Ran, Xue-Hong ; Liu, Dai-Hong ; Huang, Jin-Xiong ; Xu, Zheng-Li ; Wang, Shun-Qing ; Su, Nan ; Lu, Pei-Hua ; Liu, Li ; Bai, Guan-Chen ; Zhou, Fang ; Chen, Jie-Ping ; Zhao, Xin ; Ye, Bao-Dong ; Yang, Hai-Ping ; Sun, Zi-Min ; Guo, Zi-Wen ; Su, Guo-Hong ; Zhou, Ming ; Yi, Hai ; Fan, Sheng-Jin ; Zhang, Yan-Ming ; Jiang, Er-Lie ; Song, Xian-Min ; Huang, Xiao-Jun

Our study includes 278 patients aged between 40 and 50 years from 29 centers who received allogeneic hematopoietic stem cell transplantation (allo-HSCT) from matched sibling donors (MSDs) (n = 106) and haploidentical donors (HIDs) (n = 172) over the last decade. Univariate analysis revealed that HID recipients was associated with more serious disease severity, a delayed allo-HSCT after diagnosis, a higher pretransplant transfusion burden and poor performance status pre-transplant than MSD recipients in clinical settings. After these pretransplant clinical factors were well balanced following propensity score-matching (PSM), 80 matched pairs were selected for further analysis. Following PSM, the cumulative incidences of neutrophil were comparable between two matched groups (P = 0.14), while the 100-day engraftment rates of platelet were significant lower in HID-HCT (P < 0.001); The HID cohort showed higher cumulative incidence of grade II-IV acute graft-versus-host disease (GVHD) compared with MSD group (P = 0.04). In contrast, the incidence of severe (grade III-IV) acute GVHD and chronic GVHD were not statistically significant (severe acute GVHD P = 0.10; chronic GVHD P = 0.28). Our study observed comparable overall survival (OS) (P = 0.14); failure free survival (FFS) (P = 0.23); GVHD-free/relapse-free survival (GRFS) (P = 0.26) between matched HID and MSD recipients. In conclusion, our data indicates that allo-HSCT from an HID could be considered for SAA patients between 40 and 50 years old who do not have an MSD.

01 Jun 2025·Colloids and Surfaces B: Biointerfaces

Human amniotic mesenchymal stem cells improve patency and regeneration of electrospun biodegradable vascular grafts via anti-thrombogenicity and M2 macrophage polarization

Article

Author: He, Zhixu ; Mo, Xiumei ; Wang, Juan ; Weng, Dong ; Wang, Haoyuan ; Wang, Feng ; Wang, Bin ; Wang, Nuoxin ; He, Jing

Small-diameter vascular grafts (SDVGs) are prone to thrombosis and have low long-term patency rates for various reasons, which cannot meet the clinical requirements. In this work, Human amniotic mesenchymal stem cell (hAMSC) seeding electrospun polylactic acid-co-polycaprolactone (PLCL) SDVGs are fabricated and their application potential is systematically evaluated. The SDVG has excellent mechanical properties. PLCL eletrospinning membrane has no cytotoxicity. The SDVG has a porous fibrous tube wall, uniform distribution of hAMSCs, and good cell compatibility, blood compatibility, histocompatibility and mechanical properties. hAMSCs loading can improve the acute antithrombotic ability, patency and in vivo regeneration effect of PLCL electrospun SDVGs. The mechanism is related to hAMSCs increasing the content of endothelial cells, contractile smooth muscle cells, and M2 macrophages, as well as activating extracellular matrix production.

100 Deals associated with Liuzhou People'S Hospital

100 Translational Medicine associated with Liuzhou People'S Hospital

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