Delving into the Latest Updates on Wuxi No. 2 People's Hospital with Synapse

Overview

Tags

Respiratory Diseases

Neoplasms

Infectious Diseases

Small molecule drug

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Neoplasms	1
Infectious Diseases	1

Top 5 Drug Type	Count

Small molecule drug	2

Top 5 Target	Count

RNA binding protein	1

BACKGROUNDPrevious studies have reported that renal function is associated brain structure and cognitive dysfunction. However, the association between renal function and memory-related disease was not well characterized.METHODSAltogether, 5,282 individuals were included in this study based on China Longitudinal Study of Health and Retirement. Four estimated glomerular filtration rate indicators (eGFR), including CG, CKD-EPIscr, CKD-EPIscr-cys, and CKD-EPIcys were used to evaluate the association between renal function and memory-related disease.RESULTSThe multivariable-adjusted HRs (95% CIs) of the memory-related disease in the low eGFR group (eGFR < 90 mL/min/1.73m²) were 1.56 (1.13-2.16) for CG, 1.56 (1.19-2.06) for CKD-EPIscr, 1.45 (1.06-1.99) for CKD-EPIscr-cys and 1.27 (0.91-1.77) for CKD-EPIcys, respectively. Similarly, each SD increase of eGFR was associated with reduced risk of memory-related disease on continuous analyses. Subgroup analyses further confirmed these associations. Moreover, the addition of eGFR to conventional risk factors improved the predictive power for memory-related disease (net reclassification improvement: 13.90% for CG, 19.83% for CKD-EPIscr and 30.65% for CKD-EPIscr-cys).CONCLUSIONSIn conclusion, impaired renal function was associated with the increasing risk of memory-related disease, indicating that renal function may be a potential indicator for memory-related disease. Further studies from other races and populations are needed to replicate our findings and to clarify the potential mechanisms.

31 Dec 2025·Cell Adhesion & Migration

Orosomucoid 1 interacts with S100A12 and activates ERK signalling to expedite the advancement of bladder cancer

Article

Author: Liu, Zhe ; Pu, Xiaofeng

The research endeavors to expound the role of ORM1 in bladder cancer (BCa) and the implied response mechanism. RT-qPCR and Western blotting examined ORM1 and S100A12 expression. Functional experiments assessed the cellular phenotypes. HDOCK and Co-IP confirmed the interaction of ORM1 and S100A12. Western blotting tested apoptosis- and ERK signaling-associated proteins. ORM1 and S100A12 were abundant in the BCa cells. ORM1 or S100A12 loss impaired cell proliferation, migration, and invasion, and aggravated cell apoptosis. ORM1 interacted with S100A12. ORM1 knockdown down-regulated S100A12 expression and inactivated ERK signaling.S100A12 overexpression or ERK activator reversed the impacts of ORM1 interference on ERK signaling and BCa cells. ORM1 mightdrive BCa via binding to S100A12 and activating ERK signaling.

01 Jul 2025·Environmental Research

Simultaneous removal of Cr (VI) and norfloxacin over BiOBr nanosheet with regulated oxygen vacancies: Intermediates and toxicity evaluation

Article

Author: Shi, Haifeng ; Long, Ziyang ; Zhang, Haochun ; Chen, Yigang

Developing highly efficient photocatalysts toward simultaneous removal of chromium (Cr (VI)) and norfloxacin (Nor) in refractory wastewater was still an arduous challenge. Herein, the concentration of oxygen vacancies (OVs) in BiOBr was adjusted by a temperature control method, which could facilitate the photocatalytic Nor removal and Cr (VI) reduction. The removal capacity over V_o-BOB-90 of the photocatalytic Cr (Ⅵ) reduction and Nor degradation were 95.44 and 32.47 times higher than those of pure BiOBr, respectively. In the mixed wastewater, the V_o-BOB-90 could degrade 90.15 % of Nor within 90 min and almost all of Cr (VI) within 20 min, which was 2.71 and 1.48 times higher than single Nor and Cr (VI) solution, respectively. The improved activity could be attributed to the improved light absorption capacity and enhanced the photogenerated charges separation efficiency. Additionally, SPV, PL, and TRPL tests exhibited that the existence of OVs could regulate the electronic structure to accelerate charge transfer. Furthermore, according to the experimental data of LC-MS test and the experiment on growth of Mung bean seeds, the toxicity of the mixed solution was reduced during the degradation process. This study put forward an in-depth understanding of the removal of pollutants in complex water environments using OVs regulation.

100 Deals associated with Wuxi No. 2 People's Hospital

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100 Translational Medicine associated with Wuxi No. 2 People's Hospital

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Pipeline

Pipeline Snapshot as of 10 May 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

1

Preclinical

Other

3

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

8-Gingerol ( RNA binding protein )	Acute Lung Injury More	Preclinical
US20240051914	Neoplasms More	Discovery
89Zr-KN035 ( PDL1 )	-	Pending
18F-Al-NOTA-MATBBN(Wuxi No. 4 People's Hospital) ( GRPR )	Breast Cancer More	Pending
WXP-003 ( SPT )	Mycoses More	Pending