Xuchang Hengsheng Pharmaceutical Co. Ltd.

Primary objective: To evaluate the bioequivalence of single oral administration of Manidipine Hydrochloride Tablets (Specification: 10 mg/tablet) produced by Xuchang Hengsheng Pharmaceutical Co., Ltd. and Manidipine Hydrochloride Tablets (Specification: 10 mg/tablet, produced by Elevate Takeda Yakuhin Ltd.) produced by Teva Takeda Yakuhin Ltd. in healthy adult subjects under fasting and fed conditions. Secondary objective: To evaluate the safety of Manidipine Hydrochloride Tablets in healthy adult subjects.

Primary objective: To use Asartan Potassium Tablets developed by Xuchang Hengsheng Pharmaceutical Co., Ltd. as the test preparation and Asartan Potassium Tablets (Specification: 80 mg, Trade Name: Edabi®) produced by Takeda Ireland Ltd. as the reference preparation, to investigate the pharmacokinetic parameters and relative bioavailability of the two preparations after single administration in the fasting and postprandial state, and to evaluate whether the two preparations are bioequivalent. Secondary objective: To evaluate the safety of the test preparation and reference preparation of Asartan Potassium Tablets after a single oral administration in fasting/postprandial state in healthy Chinese participants.