Delving into the Latest Updates on Npo Vector with Synapse

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Small molecule drug	1

The potential proteolysis sites of human TNF are considered.By site-directed mutagenesis the Arg-31 residue of mature TNF was substituted by Gln.The anal. of cytotoxicity of initial and mutant (R31Q) proteins on mouse L929 fibroblasts did not reveal any differences in biol. activity.For the mutant protein a change in proteolysis dynamics was shown in contrast to the natural variant: mutant TNF displayed increased stability when treated with trypsin.

Molekulyarnaya Biologiya (Moscow)

Images of protein families for comparison with amino acid sequences

Author: Yarigin, A. A. ; Bachinsky, A. G. ; Kulichkov, V. A.

A method to develop images of protein families for fast comparison with any amino acid sequences is proposed.The method is based on physico-chem. properties of amino acids and on the choice of fragments of amino acid sequences of protein families that maximally distinguish the sequences from members of other families or random sequences.The efficiency of the method is demonstrated on comparison of images developed for protein families of alpha-interferons, alpha-Hbs, long neurotoxins, and DNA polymerases with the SWISS-PROT data bank.

Molekulyarnaya Biologiya (Moscow)

Use of markers for selection of vaccinia virus recombinants

Author: Krivogornitsyn, A. B. ; Ryazankina, O. I.

The use of selected and nonselected markers for obtaining vaccinia virus recombinants is examinedThe advantages of various selection systems are discussed.

100 Deals associated with Npo Vector

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100 Translational Medicine associated with Npo Vector

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Pipeline

Pipeline Snapshot as of 12 Jun 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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