Last update 01 Nov 2024

Birmingham City Hospital

Hospital|

United Kingdom

Hospital|

United Kingdom

Last update 01 Nov 2024

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Deal

Translational Medicine

Overview

Clinical Trials associated with Birmingham City Hospital

NCT00559052 / CompletedPhase 2

An Open-Label Cross-over Study to Evaluate the Intraduodenal Delivery of Lipase, Protease and Amylase From Administration of VIOKASE16 in Chronic Pancreatitis Subjects With Exocrine Pancreatic Insufficiency (EPI).

EPI leading to maldigestion is a frequent finding in many diseases of the pancreas, such as chronic pancreatitis (CP). Steatorrhea is the most important digestive manifestation in EPI. The current treatment of EPI includes enzyme supplementation with porcine pancreatic enzyme concentrate, consisting mainly of lipase, amylase and protease. An enzyme preparation able to deliver appropriate enzyme levels to the duodenum instead of the mid gut or distal small bowel, would appear to be clinically efficacious for the treatment of steatorrhea in subjects with CP suffering from EPI.

Start Date01 Mar 2008

Sponsor / Collaborator

Axcan Pharma (Australia) Pty Ltd.

[+2]

100 Clinical Results associated with Birmingham City Hospital

0 Patents (Medical) associated with Birmingham City Hospital

873

Literatures (Medical) associated with Birmingham City Hospital

01 Sep 2024·International Journal of Gynecologic Cancer

British Gynaecological Cancer Society/British Association of Gynaecological Pathology consensus for genetic testing in epithelial ovarian cancer in the United Kingdom

Review

Author: Keightley, Amy ; Miles, Tracie ; Gajjar, Ketan ; Frost, Jonathan ; Ganesan, Raji ; Leung, Elaine YL ; Manchanda, Ranjit ; Sundar, Sudha ; Bowen, Rebecca ; Wallis, Yvonne ; Ghaem-Maghami, Sadaf ; Leung, Elaine Yl ; Loughborough, Will ; Funingana, Ionut-Gabriel ; Andreou, Adrian ; Brenton, James D ; Nicum, Shibani ; Freeman, Susan ; Morgan, Robert D ; Jimenez-Linan, Mercedes ; Coleridge, Sarah ; Balega, Janos ; Morrison, Jo

Standard of care genetic testing has undergone significant changes in recent years. The British Gynecological Cancer Society and the British Association of Gynecological Pathologists (BGCS/BAGP) has re-assembled a multidisciplinary expert consensus group to update the previous guidance with the latest standard of care for germline and tumor testing in patients with ovarian cancer. For the first time, the BGCS/BAGP guideline group has incorporated a patient advisor at the initial consensus group meeting. We have used patient focused groups to inform discussions related to reflex tumor testing – a key change in this updated guidance. This report summarizes recommendations from our consensus group deliberations and audit standards to support continual quality improvement in routine clinical settings.

01 Sep 2024·BMJ Open Quality

Reducing maternal infection after assisted vaginal birth in a diverse and deprived population

Article

Author: Newnham, Amy ; Williamson, Megan ; Bilagi, Ashwini ; Emovon, Emmanuel ; Corrin, India ; Saxena, Dolly ; Leung, Elaine YL ; Leung, Elaine Yl

Postpartum maternal sepsis is a leading cause of maternal mortality and morbidity. A single dose of prophylactic antibiotics following assisted vaginal births has been shown to significantly reduce postpartum maternal infection in a landmark multicentre randomised controlled trial, which led to its national recommendation. This project aimed to improve the local implementation of prophylactic antibiotics following assisted vaginal births to reduce postnatal maternal infections.Using a prospectively collated birth register, data were collected retrospectively on prophylactic antibiotics administration and postnatal maternal infection rates after assisted vaginal births at the Sandwell and West Birmingham Hospitals National Health Service Trust in North-West Birmingham of the UK. The data were collected from routinely used electronic health records over three audit cycles (n=287) between 2020 and 2023.A mixed-method approach was used to improve the use of prophylactic antibiotics: (1) evidence-based journal clubs targeting doctors in training, (2) presentations of results after all three audit cycles at our and (3) expedited a formal change of local guidelines to support prophylactic antibiotics use.Prophylactic antibiotic administration increased from 13.2% (December 2021) to 90.7% (July 2023), associated with a reduction in maternal infection rates (18.2% when prophylaxis was given vs 22.2% when no prophylaxis was given). However, we observed a gradual increase in the overall postnatal maternal infection rates during the project period.Our repeat audit identified prophylactic antibiotics were regularly omitted after deliveries in labour ward rooms (59.3%), compared with 100% of those achieved in theatre. After further interventions, prophylactic antibiotics administration rates were comparable between these clinical areas (>90%) in 2023.Together, we have demonstrated a simple set of interventions that induced sustainable changes in practice. Further evaluation of other modifiable risk factors and infection rates following all deliveries is warranted in view of the gradual increase in the overall postnatal maternal infection rates.

01 Aug 2024·European Journal of Radiology

How long does it take to read a mammogram? Investigating the reading time of digital breast tomosynthesis and digital mammography

Article

Author: Khan, Humaira ; Valencia, Alexandra ; J Michell, Michael ; Sharma, Nisha ; Muscat, Elizabeth ; Satchithananda, Keshthra ; Darker, Iain ; J W Partridge, George ; Chen, Yan ; J James, Jonathan ; Teh, William

PURPOSETo analyse digital breast tomosynthesis (DBT) reading times in the screening setting, compared to 2D full-field digital mammography (FFDM), and investigate the impact of reader experience and professional group on interpretation times.METHODReading time data were recorded in the PROSPECTS Trial, a prospective randomised trial comparing DBT plus FFDM or synthetic 2D mammography (S2D) to FFDM alone, in the National Health Service (NHS) breast screening programme, from January 2019-February 2023. Time to read DBT+FFDM or DBT+S2D and FFDM alone was calculated per case and reading times were compared between modalities using dependent T-tests. Reading times were compared between readers from different professional groups (radiologists and radiographer readers) and experience levels using independent T-tests. The learning curve effect of using DBT in screening on reading time was investigated using a Kruskal-Wallis test.RESULTSForty-eight readers interpreted 1,242 FFDM batches (34,210 FFDM cases) and 973 DBT batches (13,983 DBT cases). DBT reading time was doubled compared to FFDM (2.09 ± 0.64 min vs. 0.98 ± 0.30 min; p < 0.001), and DBT+S2D reading was longer than DBT + FFDM (2.24 ± 0.62 min vs. 2.04 ± 0.46 min; p = 0.006). No difference was identified in reading time between radiologists and radiographers (2.06 ± 0.71 min vs. 2.14 ± 0.46 min, respectively; p = 0.71). Readers with five or more years of experience reading DBT were quicker than those with less experience (1.86 ± 0.56 min vs. 2.37 ± 0.65 min; p = 0.008), and DBT reading time decreased after less than 9 months accrued screening experience (p = 0.01).CONCLUSIONSDBT reading times were double those of FFDM in the screening setting, but there was a short learning curve effect with readers showing significant improvements in reading times within the first nine months of DBT experience.CLINICALTRIALSgov Identifier: NCT03733106.

100 Deals associated with Birmingham City Hospital

100 Translational Medicine associated with Birmingham City Hospital

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