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Antibody drug conjugate (ADC)

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Antibody drug conjugate (ADC)	1

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LGALS3BP x Tubulin	1

Experimental results and computational insights explain the key role of transition-metal catalysis/Brønsted acid synergism in the achievement of the sequential regioselective direct heteroarylation/cyclocondensation reactions of β-(2-aminophenyl)-α,β-ynones with a variety of electron-rich aromatic heterocyclic/arenes to afford quinoline-(hetero)aromatic hybrids. The first approach to the synthesis of 4-(1H-pyrrol-2-yl)quinolines is described. The effectiveness of various transition metals is compared.

18 May 2022·European Heart Journal Supplements

P113 HIDDEN POCKET. LEFT ATRIAL SEPTAL POUCH: VARIANT OF NORMALITY OR CARDIOEMBOLIC SOURCE?

Author: Minardi, S ; De Matteis, G ; Tocci, G ; Trambaiolo, P ; Ferraiuolo, G ; Fina, P ; Romano, S ; Renda, M ; Mustilli, M

AbstractDuring embryological period the blood flows from right to left atrium trought patent interatial septum. Embryon’s interatrial semptum consists on the apposition of Septum Secundum (SS) over Septum Primum (SP) that go to seal each other just afther birth. Sometimes this fusion doesn’t happen or partially happens, leading respectively to patent foramen ovale (PFO) or the less known eventuality of Atrial Septal Pouch (ASP).48–year–old woman, history of chronic anemia treated with blood transfusions, underwent a routine transthoracic echocardiogram (TTE) as recommended by her transfusion center. The patients is asymptomatic, denies cardiovascular risk factors, denies any signs or symptoms suggestive of recent infectious or inflammatory disease. The TTE documented preserved left ventricular sistolic function, normal sized cardiac chembers, no valvular abnormalities, evidence of linear formation (10 x 5 mm), near foramen ovale, on the left side of interatrial septum, increased in echogenicity. It was performed a transesophageal echocardiogram (TEE) which confirmed the finding at SIA level. It was therefore recommended in depth study with cardiac magnetic resonance (CMR) which described the same mobile formation, characterized by the same signal strength as the atrial walls, both before and afther contrat administration, compatible in the first hypotesis with an embryonic residue (Left Atrial Septal Pouch, LASP).There is still much uncertainty regarding the clinical significance of LASP, however, its large prevalence among general population suggests that its potential embolism requires other predisposing conditions in order to be of real clinical relevance. CMR represents a usefull test for cardiac structures analysis owing its better tissue characterization cormpared to other diagnostic tests. In the event of an occasional finding and in absence of any other indication for anticoagulant therapy, no therapeutic measures are currently indicated. These patients could be followed up in order to promptly identify the onset of prothrombotic conditions likely to expose them to higher risk compared with patients who do not have LASP.

20 Mar 2022·Mycoscience

Morpho-anatomical and molecular characterization of a native mycorrhizal Amanita species associated with Guapira opposita (Nyctaginaceae) in the brazilian Atlantic Forest

Article

Author: Rinaldi, Andrea C. ; Furtado, Ariadne Nóbrega Marinho ; Leonardi, Marco ; Comandini, Ornella ; Neves, Maria Alice

In this work, we characterize naturally occurring mycorrhizae formed by Amanita viscidolutea on Guapira opposita in the Atlantic Forest in Brazil.We sequenced the rDNA ITS region from the mycorrhizae and basidiomata to identify both symbionts.Amanita viscidolutea mycorrhizae were up to 43 mm long, mostly simple, and unbranched to irregularly pinnate.The fungal mantle surface was velvety to slightly cottony and white to yellowish with silver patches.Hyphal strands were infrequently present.Although the fungal mantle consisted of clampless hyphae, emanating hyphae and hyphal strands had sparsely distributed clamp connections.A unique character of the mycorrhizae was the absence of a Hartig net.

100 Deals associated with Universita Degli Studi Di L'Aquila

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100 Translational Medicine associated with Universita Degli Studi Di L'Aquila

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Pipeline

Pipeline Snapshot as of 23 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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