A 24-Week, Randomized, Double-blind, Placebo-controlled Clinical Study to Evaluate the Efficacy and Safety of Proso Millet and Wheat Extract(Keranat™) on Hair Health

Start Date17 Nov 2022

Sponsor / Collaborator

NOVAREX Co., Ltd.

NCT06237959 / CompletedNot Applicable

A 24-Week, Randomized, Double-blind, Placebo-controlled Clinical Study to Evaluate the Efficacy and Safety of Proso Millet and Wheat Extract(Keranat™) on Hair Health

The purpose of this randomized, double-blind, placebo-controlled study will be to evaluate whether the daily intake of Keranat™ for 24 weeks can promote the gloss and elasticity of hairs, improve their density and strength, and reduce hair loss.

Start Date02 Nov 2022

Sponsor / Collaborator

NOVAREX Co., Ltd.

KCT0008749 / CompletedNot Applicable

The efficacy and safety of Flexpro MD for joint health in individuals with mild symptoms of degenerative osteoarthritis. : 12-weeks, multicenter, randomized, double-blind, placebo-controlled human clinical trial

Start Date21 Dec 2018

Sponsor / Collaborator

NOVAREX Co., Ltd.

100 Clinical Results associated with NOVAREX Co., Ltd.

0 Patents (Medical) associated with NOVAREX Co., Ltd.

Literatures (Medical) associated with NOVAREX Co., Ltd.

18 Oct 2023·Nutrients

Effects of the Complex of Panicum miliaceum Extract and Triticum aestivum Extract on Hair Condition.

Article

Author: Choi, Nahyun ; Kim, Bumsik ; Jeong, Pan-Young ; Kim, Ki Cheon

Proso millet (Panicum miliaceum L.) and common wheat (Triticum aestivum L.) have been used as major crops in multiple regions since ancient times, and they contain various nutrients that can affect human hair health. This study investigated the various biological effects of a complex of millet extract and wheat extract (MWC) on hair health. Human immortalized dermal papilla cells (iDPCs) for an in vitro study and an anagen-synchronized mouse model for an in vivo study were employed. These findings revealed that the application of the MWC in vitro led to an increase in the mRNA levels of antioxidant enzymes (catalase and SOD1), growth factors (IGF-1, VEGF, and FGF7), and factors related to hair growth (wnt10b, β-catenin) while decreasing inflammatory cytokine mRNA levels (IL-6 and TNFα). The mRNA levels of hair follicles (HFs) in the dorsal skin of the mouse model in the early and late telogen phases were also measured. The mRNA levels in the in vivo study showed a similar alteration tendency as in the in vitro study in the early and late telogen phases. In this model, MWC treatment elongated the anagen phase of the hair cycle. These findings indicate that the MWC can suppress oxidative stress and inflammation and may elongate the anagen phase by enhancing the growth factors involved in the wnt10b/β-catenin signaling pathway. This study suggests that the MWC might have significant potential as a functional food for maintaining hair health.

07 Mar 2023·Nutrients

Chrysanthemum morifolium and Its Bioactive Substance Enhanced the Sleep Quality in Rodent Models via Cl^- Channel Activation.

Article

Author: Kim, YuJaung ; Jung, Jae-Chul ; Oh, Seikwan ; Kim, Mijin ; Lee, Hyang Woon

Dried Chrysanthemum morifolium (Chry) flowers have been used in Korea as a traditional insomnia treatment. In this study, the sleep-promoting activity and improving sleep quality of Chry extract (ext) and its active substance linarin were analyzed by pentobarbital-induced sleep experiment in mice and electroencephalography (EEG), electromyogram (EMG) analysis in rats. In a dose-dependent manner, Chry ext and linarin promoted longer sleep duration in the pentobarbital-induced sleep test compared to pentobarbital-only groups at both hypnotic and subhypnotic doses. Chry ext administration also significantly improved sleep quality, as seen in the relative power of low-frequency (delta) waves when compared with the control group. Linarin increased Cl^- uptake in the SH-SY5Y human cell line and chloride influx was reduced by bicuculline. After administration of Chry ext, the hippocampus, frontal cortex, and hypothalamus from rodents were collected and blotted for glutamic acid decarboxylase (GAD)_65/67 and gamma-aminobutyric acid (GABA)_A receptors subunit expression levels. The expression of α1-subunits, β2-subunits, and GAD_65/67 of the GABA_A receptor was modulated in the rodent brain. In conclusion, Chry ext augments pentobarbital-induced sleep duration and enhances sleep quality in EEG waves. These effects might be due to the activation of the Cl^- channel.

01 Dec 2020·BMC Complementary Medicine and TherapiesQ3 · MEDICINE

Fermented mulberry (Morus alba) leaves suppress high fat diet-induced hepatic steatosis through amelioration of the inflammatory response and autophagy pathway

Q3 · MEDICINE

ArticleOA

Author: Hong, Jin Tae ; Kang, Mi Ju ; Hwang, Dae Youn ; Lee, Mi Rim ; Bae, Su Ji ; Choi, Young Whan ; Choi, Hyeon Jun ; Kim, Ji Eun ; Kim, Kyung Mi ; Park, Ji Won

AbstractBackgroundA novel extract of mulberry leaves fermented with Cordyceps militaris (EMfC) is reported to exert anti-obesity activity, although their molecular mechanism during hepatic steatosis has not verified.MethodsTo investigate the role of inflammation and autophagy during the anti-hepatic steatosis effects of EMfC, we measured alterations in the key parameters for inflammatory response and autophagy pathway in liver tissues of the high fat diet (HFD) treated C57BL/6N mice after exposure to EMfC for 12 weeks.ResultsSignificant anti-hepatic steatosis effects, including decreased number of lipid droplets and expression of Klf2 mRNA, were detected in the liver of the HFD + EMfC treated group. The levels of mast cell infiltration, expression of two inflammatory mediators (iNOS and COX-2), and the MAPK signaling pathway were remarkably decreased in the liver of HFD + EMfC treated group as compared to the HFD + Vehicle treated group. Furthermore, a similar inhibitory effect was measured for the expression levels of pro-inflammatory cytokines, including IL-1β, IL-6, TNF-α and NF-κB. The expression level of members in the AKT/mTOR signaling pathway (a central regulator in autophagy) was recovered after treatment with EMfC, and autophagy-related proteins (Beclin and LC3-II) were remarkably decreased in the HFD + EMfC treated group compared to the HFD + Vehicle treated group. Moreover, the HFD + EMfC treated group showed decreased transcript levels of autophagy-regulated genes including Atg4b, Atg5, Atg7 and Atg12.ConclusionsTaken together, findings of the present study provide novel evidences that the anti-hepatic steatosis of EMfC is tightly linked to the regulation of the inflammatory response and autophagy pathway in the liver tissue of HFD-induced obesity mice.

100 Deals associated with NOVAREX Co., Ltd.

100 Translational Medicine associated with NOVAREX Co., Ltd.

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