Lijin Biomedical Technology Shanghai Co. Ltd.

DUBLIN--( BUSINESS WIRE )--The "CD137 Antibodies Clinical Trials & Market Opportunity Insight 2027" report has been added to ResearchAndMarkets.com's offering. CD137, also known as 4-1BB, has emerged as a promising target for cancer immunotherapy in recent years. The potential of CD137-targeted therapies lies in their ability to stimulate and expand cytotoxic T cells leading to improved tumor cell killing and long-lasting immune memory. As a result, the field has gained attention from researchers and pharmaceutical companies alike, with several research publications hinting at a promising future for this cancer therapeutic approach. Moreover, data emerging from early clinical trials have already begun demonstrating therapeutic benefits, providing real-time validation of CD137-targeted drug development. With no licensed medications currently on the market, CD137-targeted therapies are still in their infancy. Nonetheless, there is an abundance of candidates in the pipeline in different phases of clinical development, with phase 2 being the highest. Several major pharmaceutical companies and biotech firms, including BioNTech, Genmab, Adagene, and Shanghai Henlius Biotech, are actively pursuing drug development programs after recognizing the potential of this target. This presents a significant opportunity for both established players and newcomers in the field of immuno-oncology. The ability of CD137-targeted treatments to get past some of the drawbacks of existing immunotherapies, like immune checkpoint inhibitors, is one of their main advantages. Although checkpoint inhibitors have fundamentally altered the way that cancer is treated, only a small percentage of patients and cancer types respond well to them. The range of individuals who can benefit from immunotherapy may be increased by CD137 agonists, which may enhance or supplement the effectiveness of these currently available treatments. The most advanced CD137-targeted therapies in clinical development are agonistic antibodies. The intended effect of these compounds is to stimulate T cell survival, proliferation, and effector activities via activating CD137 signaling. Regarding anti-tumor effectiveness and safety characteristics, early clinical trials have produced encouraging results. YH004, ADG106, ADG206, and ATOR-1017 are a few CD137 agonistic antibodies that are now undergoing clinical trials. There have been challenges, nevertheless, such as dose-limiting hepatotoxicity seen in certain candidates. Due to this, other strategies are being investigated that might provide better safety and efficacy profiles, such as bispecific antibodies and tailored ligands. Combining CD137-targeted therapies with other immunomodulatory drugs is one highly intriguing area of investigation. CD137 agonists have been shown to have synergistic benefits when paired with checkpoint inhibitors, chemotherapy, targeted therapy, or even radiation therapy, according to preclinical research and early phase clinical evidence. These combination approaches may result in more potent and more persistent anti-tumor responses, which would fulfill the unmet demand for efficient treatments for malignancies that are challenging to treat. The market potential for effective CD137 antibodies is significant, considering the wide range of applications of CD137-targeted treatments in cancer. New and efficient treatment modalities are highly sought after, as the global market for cancer immunotherapy is expected to grow to many billions of dollars in the next several years. A sizeable portion of this market may be taken up by CD137-targeted treatments, especially if they show greater efficacy and can treat conditions where immunotherapies have not been very successful. Furthermore, the versatility of CD137 as a target extends beyond oncology. Recent studies point to possible uses in transplantation, autoimmune diseases, inflammatory disorders, and infectious diseases. This wide-ranging therapeutic potential could open up additional market opportunities for drug developers, willing to explore these indications. Despite the promising outlook, several challenges need to be addressed in the development of CD137-targeted therapies. These include optimizing dosing regimens to balance efficacy and safety, identifying predictive biomarkers for patient section, and developing strategies to overcome potential resistance mechanisms. Overcoming these hurdles will be crucial for the successful translation of CD137-targeted therapies from bench to bedside. In conclusion, CD137-targeted therapies represent a significant opportunity to transform treatment of cancer and various other diseases involving the immune system. The increasing comprehension of CD137 biology, in conjunction with developments in antibody engineering and combination strategies, offers a robust basis for novelty in this domain. CD137-targeted therapies have the potential to fill a significant gap in the medical community and gain a significant portion of the cancer immunotherapies market, which presents a strong case for development and innovation. CD137 Antibodies Clinical Trials & Market Opportunity Insight 2027 Report Highlights: Currently No Drug Commercially Available In Market More Than 80 Drugs In Clinical Trials Highest Clinical Trials Phase: Phase II (7 Drugs) CD137 Drugs Market Opportunity In Initial 24 Months Of Launch: > US$ 400 Million Global & Regional Trends (Clinical & Commercial) CD137 Inhibitors Clinical Trials Insight By Company, Country, Indication & Phase CD137 Therapeutic Approaches By Antibodies Classification Role Of CD137 & Clinical Progress By Indication Key Topics Covered: 1. Brief Introduction To CD137 1.1 Clinical Overview 1.2 Biological History Of CD137 1.3 CD137 Hosting An Era Of Agonists Over Antagonists 1.4 Bi-Directional Signaling In CD137 2. Global CD137 Antibody Market Outlook 2.1 Current Research & Market Scenario 2.2 Future Commercialization Opportunities 3. CD137 Antibody Clinical Developments by Regions 3.1 China 3.2 US 3.3 South Korea 3.4 Europe 3.5 Australia 4. Role Of CD137 & Clinical Progress By Indication 4.1 Cancer 4.1.1 Leukemia 4.1.2 Lymphoma 4.1.3 Lung Cancer 4.1.4 Melanoma 4.1.5 Breast Cancer 4.1.6 Colorectal Cancer 4.2 Autoimmune & Inflammatory Diseases 4.3 Microbial Infections 4.3.1 Viral Infections 4.3.2 Bacterial infections 5. Global CD137 Antibodies Clinical Trials Overview 5.1 By Company 5.2 By Country 5.3 By Indication 5.4 By Phase 5.5 By Patient Segment 6. CD137 Inhibitors Clinical Trials Insight By Company, Country, Indication & Phase 6.1 Research 6.2 Preclinical 6.3 Phase I 6.4 Phase I/II 6.5 Phase II 7. CD137 Targeting Proprietary Technology Platforms By Companies 8. CD137 Therapeutic Approaches By Antibodies Classification 8.1 Monoclonal Antibody Based Strategies 8.2 Bispecific Antibody Centered Approaches 8.3 Trispecific Antibody Established Strategies 8.4 Tetraspecific Antibody Strategies 9. Combination Therapies With CD137 Antibodies 10. Competitive Landscape ABL Bio Adagene Alligator Bioscience BeiGene Bicycle Therapeutics BioNTech Biotheus Crescendo Biologics Eutilex F-star Therapeutics Genmab I-MAB Biopharma Lyvgen Biopharma OriCell Therapeutics Pieris Pharmaceuticals Shanghai Henlius Biotech Sichuan Baili Pharmaceutical SystImmune For more information about this report visit https://www.researchandmarkets.com/r/uh1uil About ResearchAndMarkets.com ResearchAndMarkets.com is the world's leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends.

LVGN7409 is a next generation CD40 agonistic antibody; Nivolumab is a PD-1 checkpoint inhibitor; docetaxel is an anti-tubulin chemotherapy agent Combination study to begin in 1st half 2023 SHANGHAI and SUZHOU, China, Nov. 27, 2022 /PRNewswire/ -- Lyvgen Biopharma, a leading innovative global biotech company dedicated to discovering, developing and commercializing first-in-class and best-in-class biotherapeutics for cancer, announced today an open label, phase 2, multicenter, randomized trial of LVGN7409 plus docetaxel or, in collaboration with Bristol Myers Squibb, nivolumab in patients with advanced/metastatic Non-Small Cell Lung Cancer (NSCLC). "Lyvgen clinical collaboration with Bristol Myers Squibb underscores our commitment to exploring combination regimens from our portfolio with complementary mechanisms of action that may transform cancer care", said Jieyi Wang, Ph.D., Founder and CEO of Lyvgen. "We are excited to enter this clinical collaboration with Bristol Myers Squibb and look forward to initiating enrollment in these combination regimens for patients who cannot benefit from existing therapy worldwide." LVGN7409, a recombinant monoclonal antibody that targets CD40 for activation optimally in tumor microenvironment, which is a member of the tumor necrosis factor (TNF) receptor family (TNFRSF5) and modulates immune responses by activating antigen presenting cells and reprograming the immuno-suppressive tumor microenvironment. Bristol Myers Squibb's nivolumab is a human monoclonal antibody that binds to the PD-1 and blocks its interaction with PD-L1 and PD-L2, releasing PD-1 pathway-mediated inhibition of the immune response, including the anti-tumor immune response. Docetaxel is an anti-tubulin chemotherapy agent used to treat a number of types of cancer, including non-small-cell lung cancer, breast cancer, head and neck cancer, stomach cancer, and prostate cancer. "Lyvgen believes that the combination therapy targeting co-stimulatory checkpoint CD40 and co-inhibitory checkpoint PD-1, may offer the greatest chance to increase immunotherapy effectiveness in patients with resistant or refractory diseases, further validating the synergy observed in our pre-clinical studies for the combination of LVGN7409 and an immune check-point inhibitors." said Hubert Chan, M.D., Ph.D., Chief Medical Officer. " We also believe LVGN7409 may be useful in combination with immune-modulating chemotherapy agents such as docetaxel. Through this phase 2 study, we are enthusiastic to demonstrate that the stimulation of CD40 has the potential to reverse an immune-suppressed tumor microenvironment characterized by drug resistance and to improve anti-tumor efficacy when added to the current 'standard of care' therapy. There is a significant unmet medical need for the refractory NSCLC patients, and we hope this study will bring promising results to those cancer patients." continued Dr. Chan. Clinical benefits for patients must be proven through rigorous clinical studies. There are no shortcuts. Lyvgen's focus on immune agonists is widely applicable for most cancer indications. Our xLinkAb platform helps achieve a balance between safety and efficacy, which can greatly increase the chances of success. The advantages of agonistic antibodies have been validated in several preclinical and clinical studies. At present, the agonistic antibody field is still young, but developing rapidly with huge potential as a hot field of cancer immunotherapy. Our strength and long-term engagement in immune-oncology agonistic antibodies are returning primary promising clinical results. The Lyvgen pipeline of biologics may be benefit-cost effective drugs for a large panel of cancer indications. Under the terms of the Agreement, Lyvgen will sponsor the study and Bristol Myers Squibb will provide nivolumab for the combination trial. Lyvgen has global commercial and development rights to LVGN7409. About LVGN7409 LVGN7409 is a next generation CD40 agonistic monoclonal antibody developed on Lyvgen xLinkAb platform, which activates CD40 to promote tumor antigen presentation and induction of cancer-fighting T cells, and "warms up" the immune-"cold" tumor microenvironment. Unique structure and functionality of LVGN7409 permits its higher tolerable dosage and broader clinical utility. About Lyvgen Lyvgen is an innovative biotech company focused on developing novel therapies for cancer. Its proprietary xLinkAb functional platform generated agonistic antibodies with tumor-localized immunostimulatory activities by balancing multiple functions of candidate antibodies, which has helped to generate a number of drug candidates, including LVGN7409 (CD40 agonist mAb) and LVGN6051 (4-1BB agonist mAb), presently in clinical development. The phase 1 clinical trial of LVGN7409 has been advanced in China and the United States with preliminary clinical breakthrough safety and activity data. LVGN6051 monotherapy has demonstrated safety and activity and is being tested in a phase 1b /2 trial in the United States with pembrolizumab in adults with advanced tumors. LVGN6051 is also in Phase 2 clinical trial in China in combination with small molecule inhibitors of vascular endothelial growth factor receptor. Related Link SOURCE Lyvgen Biopharma

PD-1 and PD-L1 inhibitors clinical trial pipeline constitutes 180+ key companies continuously working towards developing 200+ PD-1 and PD-L1 inhibitors drugs, analyzes DelveInsight LAS VEGAS, Nov. 14, 2022 /PRNewswire/ -- DelveInsight's ' PD-1 and PD-L1 Inhibitors Competitive Landscape – 2022 ' report provides comprehensive global coverage of available, marketed, and pipeline PD-1 and PD-L1 inhibitors drugs in various stages of clinical development, major pharmaceutical companies are working to advance the pipeline space and future growth potential of the PD-1 and PD-L1 inhibitors competitive domain. Key Takeaways from the PD-1 and PD-L1 Inhibitors Pipeline Report Over 180+ PD-1 and PD-L1 inhibitors companies are evaluating 200+ PD-1 and PD-L1 inhibitors pipeline therapies in various stages of development, and their anticipated acceptance in the PD-1 and PD-L1 inhibitors market would significantly increase market revenue. Leading PD-1 and PD-L1 inhibitors companies such as Merck, Laekna Therapeutics, Genentech, Tracon Pharmaceuticals Inc., Celgene, MedImmune, Hangzhou Sumgen Biotech, Lepu Biopharma, Harbour BioMed, Curis, BeiGene, Apollomics, Agenus, Boehringer Ingelheim, Jounce Therapeutics, Seagen Inc., Ascletis Pharma Inc., Secarna Pharmaceuticals GmbH & Co. KG, Arbutus Biopharma, ABL bio, Macrogenics, AnaptysBio, Avacta, Regeneron Pharmaceuticals, Genor Biopharma Co. Ltd, Genmab, RemeGen, Alphamab, OxSonics therapeutics, Light Chain Bioscience, ImmuneOnco Biopharma, Alpine Immune Sciences, Shanghai Henlius Biotech, Inc., Ocean Biomedical, Akeso Biopharma, Lyvgen Biopharma, Prestige Biopharma, ONO PHARMACEUTICAL CO., LTD., Innovent Biologics, QLSF Biotherapeutics Inc., Servier, Zai Lab, EQRx, Bright Peak Therapeutics, Compass Therapeutics, Inc., Y-Biologics, Shattuck Labs, Beijing Biocytogen, Transcenta Holding, KLUS Pharma Inc., Synermore Biologics, F-Star Therapeutics Inc., Alphamab Oncology, Betta Pharmaceuticals Co., Ltd., Bolt Biotherapeutics, Medicenna Therapeutics, Celldex Therapeutics Inc., TCR² Therapeutics, Transcenta Holding, Merus, SystImmune Inc., TG Therapeutics, Elpiscience, Numab, Janux Therapeutics, Adagene, Molecular Templates, Inc., ImmuneOncia, and others are evaluating novel PD-1 and PD-L1 inhibitors drug candidates to improve the treatment landscape. Key PD-1 and PD-L1 inhibitors pipeline therapies in various stages of development include Envafolimab, Keytruda, FAZ053, TECENTRIQ, Durvalumab, SG 12473, LP 002, HBM 9027, CA 170, Tislelizumab, Geptanolimab, and others. In October 2022, ChemoCentryx, Inc. announced two upcoming poster presentations for CCX559, the Company's investigational, highly potent, orally administered PD-L1 checkpoint inhibitor, at the Society for Immunotherapy of Cancer (SITC) 37th Annual Meeting, which will be held November 8-12, 2022, in Boston, MA. In October 2022, Compugen Ltd., a clinical-stage cancer immunotherapy company and a pioneer in computational target discovery, announced that it will present new clinical data from its COM701/nivolumab with or without BMS-986207 combination studies in patients with platinum-resistant ovarian cancer, as well as data from the COM701 with or without nivolumab study in patients with metastatic NSCLC, as poster presentations at the European Society of Medical Oncology Immuno-Oncology (ESMO-IO) congress taking place between December 7-9, 2022, in Geneva, Switzerland. In October 2022, Imjudo (tremelimumab) from AstraZeneca was approved in the United States in combination with Imfinzi (durvalumab) for the treatment of adult patients with unresectable hepatocellular carcinoma (HCC), the most common type of liver cancer. In October 2022, GSK announced positive top-line results from the PERLA phase II trial, which met its primary endpoint of objective response rate (ORR) by Response Evaluation Criteria in Solid Tumors (RECIST) criteria as determined by blinded independent central review. In September 2022, Merck announced that KEYTRUDA, Merck's anti-PD-1 therapy, received four new approvals from Japan's Ministry of Health, Labor, and Welfare (MHLW). In July 2022, TRACON Pharmaceuticals, Inc. announced the enrollment of the 36^th patient in the ENVASARC pivotal trial at the 600 mg dose of envafolimab, which enables the initial independent data monitoring committee (IDMC) interim efficacy analysis to proceed. The interim analysis is expected to occur in the fourth quarter of this year. In January 2022, Merck announced that the European Commission had approved KEYTRUDA as monotherapy for the adjuvant treatment of adults with renal cell carcinoma (RCC) at increased risk of recurrence following nephrectomy or following nephrectomy and resection of metastatic lesions. Request a sample and discover the recent advances in the PD-1 and PD-L1 inhibitors market @ PD-1 and PD-L1 Inhibitors Competitive Landscape Report PD-1 and PD-L1 Inhibitors Overview Cancer cells have programmed cell death protein 1 (PD-1) on their surfaces. Tumors use it to evade the immune system, so blocking it allows the body to attack and kill cancer. T cells constantly scan our bodies for abnormal cells and eliminate them before they can become cancerous. Finding ways to avoid or shut down the immune system is a critical step in tumor development. PD-1 proteins interact with two ligands, Programmed death-ligand 1 (PD-L1) and Programmed death-ligand 2 (PD-L2). The CD274 gene in humans encodes PD-L1. Some of the FDA-approved PD-1 inhibitor drugs include pembrolizumab (Keytruda), nivolumab (Opdivo), and cemiplimab (Libtayo). These drugs effectively treat various cancers, and new cancer types are added as more research demonstrates their efficacy. PD-L1 inhibitor drugs include atezolizumab (Tecentriq), avelumab (Bavencio), and durvalumab (Imfinzi). Find out more about PD-1 and PD-L1 inhibitors drugs @ FDA-approved PD-1 Inhibitor Drugs PD-1 and PD-L1 Inhibitors Pipeline Analysis: Drug Profile Keytruda: Merck Merck's Keytruda is a humanized monoclonal antibody that binds to the programmed cell death - 1 (PD-1) receptor and blocks its interaction with PD-L1 and PD-L2, releasing PD-1 pathway-mediated inhibition of the immune response, including anti-tumor immune response. Keytruda has been approved for advanced melanoma, non-small cell lung cancer (NSCLC), head and neck squamous cell cancer, classical Hodgkin lymphoma, microsatellite-instability-high cancer, Gastric Cancer, Esophageal Cancer, Cervical Cancer, Hepatocellular Carcinoma, Merkel Cell Carcinoma, Renal Cell Carcinoma, Endometrial Carcinoma, and advanced urothelial bladder cancer. FAZ053: Laekna Therapeutics Laekna Therapeutics is developing FAZ053 (anti-PD-L1), an investigational immuno-oncology treatment for patients with advanced cancers. It is a monoclonal antibody that targets the protein programmed cell death-1 ligand 1. (PD-L1). FAZ053, an anti-PD-L1 monoclonal antibody, binds to PD-L1, preventing it from binding to and activating its receptor programmed death 1 (PD-1), potentially enhancing the T-cell-mediated anti-tumor immune response and reversing T-cell inactivation. Laekna intends to begin trials on combination therapies as soon as possible to address unmet cancer needs and bring innovative, effective treatments to more cancer patients in China. A snapshot of the PD-1 and PD-L1 Inhibitors Pipeline Drugs mentioned in the report: Learn more about the emerging PD-1 and PD-L1 inhibitors pipeline therapies @ PD-1 and PD-L1 Inhibitors Clinical Trials Scope of the PD-1 and PD-L1 Inhibitors Competitive Landscape Report Coverage: Global Key PD-1 and PD-L1 Inhibitors Companies: Merck, Laekna Therapeutics, Genentech, Tracon Pharmaceuticals Inc., Celgene, MedImmune, Hangzhou Sumgen Biotech, Lepu Biopharma, Harbour BioMed, Curis, BeiGene, Apollomics, Agenus, Boehringer Ingelheim, Jounce Therapeutics, Seagen Inc., Ascletis Pharma Inc., Secarna Pharmaceuticals GmbH & Co. KG, Arbutus Biopharma, ABL bio, Macrogenics, AnaptysBio, Avacta, Regeneron Pharmaceuticals, Genor Biopharma Co. Ltd, Genmab, RemeGen, Alphamab, OxSonics therapeutics, Light Chain Bioscience, ImmuneOnco Biopharma, Alpine Immune Sciences, Shanghai Henlius Biotech, Inc., Ocean Biomedical, Akeso Biopharma, Lyvgen Biopharma, Prestige Biopharma, ONO PHARMACEUTICAL CO., LTD., Innovent Biologics, QLSF Biotherapeutics Inc., Servier, Zai Lab, EQRx, Bright Peak Therapeutics, Compass Therapeutics, Inc., Y-Biologics, Shattuck Labs, Beijing Biocytogen, Transcenta Holding, KLUS Pharma Inc., Synermore Biologics, F-Star Therapeutics Inc., Alphamab Oncology, Betta Pharmaceuticals Co., Ltd., Bolt Biotherapeutics, Medicenna Therapeutics, Celldex Therapeutics Inc., TCR² Therapeutics, Transcenta Holding, Merus, SystImmune Inc., TG Therapeutics, Elpiscience, Numab, Janux Therapeutics, Adagene, Molecular Templates, Inc., ImmuneOncia, and others Key PD-1 and PD-L1 Inhibitors Pipeline Therapies: Envafolimab, Keytruda, FAZ053, TECENTRIQ, Durvalumab, SG 12473, LP 002, HBM 9027, CA 170, Tislelizumab, Geptanolimab, and others. Dive deep for rich insights into PD-1 inhibitors in development; visit @ PD-L1 Inhibitor Drugs Table of Contents For further information on the PD-1 and PD-L1 inhibitors pipeline therapeutics, reach out @ PD-1 and PD-L1 Inhibitors Market Related Reports PD-1 Resistant Head and Neck Cancer Market PD-1 Resistant Head and Neck Cancer Market Insights, Epidemiology, and Market Forecast – 2032 report deliver an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the market trends, market drivers, market barriers, and key PD-1 resistant head and neck cancer companies, including AstraZeneca, Innate Pharma, Rakuten Medical, Boehringer Ingelheim, Alkermes, among others. 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