This prospective, double-blind, parallel-group controlled trial aims to investigate the consequence of early trauma on dopamine release evoked by positive valence odors.

Start Date01 Jun 2025

Sponsor / Collaborator

Centre Hospitalier le Vinatier

NCT06869915

/ Not yet recruitingNot ApplicableIIT

Prevalence of Neurodevelopmental Disorders in a Homeless Population - Pilot Study

Introduction & Central question: Psychiatric disorders are highly prevalent in the homeless population, however neurodevelopmental disorders are also at risk of leading to homelessness (Churchard et al., 2018; Casey et al., 2020). Research on this topic is poor in France. This research aims to study the prevalence in France of 3 neurodevelopmental disorders (NDDs) in a homeless population (Autism Spectrum Disorder, Attention Deficit Hyperactivity Disorder and Intellectual Developmental Disorder).
Methods / approach: A 2 phase approach will be used including a screening phase and a diagnosis phase. This research is a pilot study that will include 150 homeless people, over 2 years. The assessment involves combining the results from standardised self-report tools, direct observation and informant-report, thus guaranteeing an objective and thorough diagnosis. This approach gives a better picture of actual behaviour but also a better understanding of the person's development.
OUTCOME: This study will give insight on how to better understand the profile of the homeless population in France, and the prevalence of autism in this population. It will also bring valuable knowledge on how autism and other NDDs can impact one's path in life and lead to homelessness. The results can help develop targeted cares and measures for homeless people with NDDs.

Start Date01 Apr 2025

Sponsor / Collaborator

Centre Hospitalier le Vinatier

NCT06866925

/ Not yet recruitingNot ApplicableIIT

Transcranial Direct Current Stimulation as a Treatment for Depression With Catatonic Features in Patients With Down Syndrome: a Pilot Randomized Sham-controlled Study

This study evaluates the efficacy of transcranial direct current stimulation (tDCS) for depression with catatonia in individuals with Down syndrome (DS). 62 patients will be randomized to receive 15 sessions of active or sham tDCS. The primary objective is to measure changes in depressive/catatonic symptoms using the Bush-Francis Catatonia Rating Scale (BFCRS). Secondary objectives include safety, cognitive effects, EEG correlates, and biological markers (cortisol, BDNF, cytokines). The study aims to provide a non-pharmacological therapeutic alternative for this population

Start Date01 Apr 2025

Sponsor / Collaborator

Centre Hospitalier le Vinatier

100 Clinical Results associated with Centre Hospitalier le Vinatier

0 Patents (Medical) associated with Centre Hospitalier le Vinatier

357

Literatures (Medical) associated with Centre Hospitalier le Vinatier

31 Dec 2025·Dialogues in Clinical Neuroscience

Prevalence of attention deficit hyperactivity disorder in homeless children and adolescents: A systematic review and meta-analysis

Review

Author: Vallet, William ; Brunelin, Jérôme ; Jurek, Lucie ; Demily, Caroline ; Boucaud-Maitre, Denis ; Denis, Charles

INTRODUCTIONThis systematic review and meta-analysis aimed to examine the prevalence of Attention deficit hyperactivity disorder (ADHD) in homeless children and adolescents, and the factors that may influence its prevalence.METHODSRelevant publications in Medline, Web of Science, Scopus and PsycINFO were systematically searched to identify studies on the prevalence of ADHD in homeless children and adolescents (≤19 years). The extracted data were pooled using a random-effects model.RESULTSThirteen studies involving 2878 homeless children and adolescents were included (mean age: 12.0 years, sex F/M: 0.43). The prevalence rates of ADHD vary considerably across studies, ranging from 1.6% to 64.5%. The pooled prevalence of ADHD was 22.8% (95% CI 12.9-34.4%, I² =98%). Meta-regression analyses indicated that age (slope = 0.046; p = .042) significantly increased ADHD prevalence. The prevalence of ADHD in studies with a mean age ≥ 12 years (43.1%, 95% CI 26.5-60.4%) was higher than those with a mean age < 12 years (13.1%, 95%CI 4.3-25.6).CONCLUSIONDespite the high heterogeneity of the studies, we observed that ADHD could affect almost a quarter of homeless children and adolescents. Reintegrating them into care systems and ensuring access to public health interventions tailored for homeless families and youth is imperative for breaking the cycle of homelessness and improving long-term trajectories.

01 May 2025·Sleep Medicine

Determinants of substance use patterns in patients with narcolepsy type 1: A multi-center comparative cross-sectional study

Article

Author: Arnulf, Isabelle ; de La Tullaye, Sylvie ; Peter-Derex, Laure ; Charley-Mocana, Christelle ; Mazza, Stéphanie ; Léotard, Antoine ; Limousin, Nadège ; Putois, Benjamin ; Dauvilliers, Yves ; Brigandet, Manon ; Philip, Pierre ; Leclair-Visonneau, Laurene ; Fort, Emmanuel ; Franco, Patricia ; Barateau, Lucie ; Bastuji, Hélène ; Charbotel, Barbara ; Lecendreux, Michel ; Dodet, Pauline ; Debs, Rachel ; Lemesle-Martin, Martine ; Meslier, Nicole ; Lopez, Régis ; Rolland, Benjamin ; Martel, Nora ; Ricordeau, François ; Lambert, Isabelle ; Leu-Semenescu, Smaranda ; Bourgin, Patrice ; Ruppert, Elisabeth ; Micoulaud-Franchi, Jean-Arthur ; Léger, Damien ; Dudoignon, Benjamin ; Hartley, Sarah ; d'Ortho, Marie-Pia

OBJECTIVESIn this multi-center cross-sectional study, we compared substance use patterns (SUPs) between patients with narcolepsy type 1 (NT1) and controls, and investigated, among patients, factors associated with the consumption of the main psychoactive substances.METHODSAdult patients with NT1 and controls completed questionnaires about tobacco, alcohol, and cannabis use patterns. Unadjusted bivariable then multivariate analyses (adjusted for sex, age, education, family status, and depression) were performed to compare SUPs between controls and patients, and to explore socio-demographic, psycho-behavioral, and clinical determinants of consumptions.RESULTSWe included 235 patients (63.8 % women, 36.4 ± 14.7 years) and 166 controls (69.9 % women, 40.3 ± 14.4 years). Substances co-consumptions were frequent in both groups. Patients with NT1 were more frequently current smokers (32.3 % vs. 20.1 %, p < 0.01) or e-cigarettes users (12.1 % vs 2.4 %, p < 0.001) than controls, while no difference was observed for cannabis use and alcohol misuse. Only the increased likelihood of vaping remained significant in adjusted analysis. Among NT1 patients, smoking was associated with disrupted nighttime sleep (OR[95%CI] = 2.28[1.02-5.12], p < 0.05) and less obesity (OR = 0.24[0.09-0.59], p < 0.05). Alcohol misuse was associated with sleep paralysis (OR = 2.11[1.13-3.91], p < 0.05) and treatments (modafinil: OR = 2.14[1.15-4.01], p < 0.05; sodium oxybate: OR = 0.41[0.17-0.97], p < 0.05). Tobacco and cannabis consumptions were associated with lower physical activity (OR = 0.46 [0.24-0.87], p < 0.05 and OR = 0.25[0.10-0.66], p < 0.01). Alcohol misuse and cannabis use were associated with rule breaking behaviors (OR = 5.89[1.61-21.60], p < 0.05 and OR = 8.52[1.79-40.48], p = 0.01).CONCLUSIONPatients with NT1 do not seem less vulnerable to psychoactive substance use/misuse. Consumptions patterns are associated with multiple dimensions of the disease including sleep-related symptoms, comorbidities, treatments, and psycho-behavioral factors.

01 Apr 2025·Journal of the American Academy of Child & Adolescent Psychiatry

Sensory Processing in Individuals With Attention-Deficit/Hyperactivity Disorder Compared to Control Populations: A Systematic Review and Meta-Analysis

Article

Author: Henault, Léonie ; Fourneret, Pierre ; Duchier, Arnaud ; Giroudon, Caroline ; Gauld, Christophe ; Nourredine, Mikail ; Cortese, Samuele ; Jurek, Lucie

OBJECTIVEIn this systematic review and meta-analysis, we evaluated the association between Attention-Deficit/Deficit Hyperactivity (ADHD) and atypical Sensory Processing Patterns (SPPs).METHODWe searched PubMed, Embase, and Web of Science from their inception until June 30^th, 2024. We included studies examining SPP using questionnaires in participants with a diagnosis of ADHD compared with healthy controls. The study risk of bias was assessed using a modified Newcastle-Ottawa Scale. A random-effects meta-analysis was conducted using R software (Version 4.3.1), considering sensory modulation atypicities severity as the primary outcome. We explored the risk of publication bias and conducted sensitivity analyses to test the robustness of the findings.RESULTSAfter screening 10,750 references, we included 30 studies (reported in 32 publications) encompassing a total of 5,374 participants, with 23 studies focusing on children, and seven on adults. Patients with ADHD presented significantly more severe sensory atypicities than the control group in multiple domains: sensory sensitivity (k=13; SMD=1.17; 5% CI [0.75;1.59]; I²=87%), sensory avoiding (k=11; SMD=1.15; 95% CI [0.66;1.64]; I²=92%), low sensory registration (k=23; SMD=1.22; 95%CI [0.89;1.56]; I²=92%), and sensory seeking (k=15; SMD=1.23; 95%CI [0.48;1.97]; I²=97%). Heterogeneity was high in all analyses. Only nine studies were deemed at overall low risk of bias.CONCLUSIONEven though available ADHD clinical guidelines do not specifically mention the need to assess sensory processing in ADHD, our meta-analysis suggests that this should be systematically explored in the evaluation of children and adults referred for ADHD.

100 Deals associated with Centre Hospitalier le Vinatier

100 Translational Medicine associated with Centre Hospitalier le Vinatier

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