Sanford Burnham Prebys Medical Discovery Institute

Conference call today, May 13, 2026, at 4:30 PM ET SAN DIEGO, May 13, 2026 (GLOBE NEWSWIRE) -- Bionano Genomics, Inc. (Nasdaq: BNGO) today reported financial results for the first quarter ended March 31, 2026. "The Bionano business is healthy, with first quarter results reflecting the continued engagement of our installed base and positive utilization trends across our optical genome mapping (OGM) and VIA software user community," commented Al Luderer, Ph.D., chairman and interim chief executive officer of Bionano. "The evidence base supporting OGM continues to expand across hematologic malignancies, constitutional genetics, and cell and gene therapy applications, and we are seeing global broad-based adoption at leading institutions. We remain convinced that OGM is on a clear and accelerating path to becoming the standard for comprehensive, genome-wide structural variant analysis. Equally important, we are closing in on a meaningful balance sheet milestone - the expected retirement of our secured convertible debt - which will further strengthen our financial position and allow us to direct future capital towards growing our business.” Q1 2026 Financial Results For the three-month period ended March 31, 2026, as compared to the same period of 2025: Reported total revenue of $6.7 million, representing an increase of 4% from $6.5 million compared to the first quarter of 2025. Consumables revenue was $3.9 million, representing an increase of 20% compared to the first quarter of 2025. Sold 8,178 nanochannel array flow cells in the first quarter of 2026, representing an increase of 17% over the 6,994 flow cells sold in the first quarter of 2025. Generated gross margin of 49%, compared to 46% for the first quarter of 2025, and adjusted gross margin 1 of 49%, compared to 46% for the first quarter of 2025. Reduced operating expenses by 2% to $11.1 million and increased adjusted operating expense 1 by 7% to $9.1 million. Recent Business Highlights: January 1, 2026, a new Category I CPT code (81354) for the use of OGM in cytogenomic genome-wide analysis to detect structural and copy number variations related to constitutional genetic disorders, went effective on the clinical lab fee schedule (CLFS). The new code covers the OGM-Dx™ Postnatal Whole Genome SV and OGM-Dx™ Prenatal Whole Genome SV LDTs and is priced above comparable microarray codes. Final 2026 Clinical Lab Fee Schedule reflected a 47% increase in the payment determination for CPT code 81195, covering OGM use in hematologic malignancy analysis, rising from $1,263.53 to $1,853.22, effective January 1, 2026. New publication from Johns Hopkins and MD Anderson Cancer Center in the American Journal of Hematology demonstrating that OGM can significantly outperform traditional analytical methods for detection of structural variations and chromosomal abnormalities in multiple myeloma. New publication from Sanford Burnham Prebys Medical Discovery Institute describing use of OGM to detect genomic alterations introduced by gene editing technologies. Demonstrated growing utility of OGM in analysis of rare diseases with 28 publications in the first quarter, a 56% increase over the prior year period. Highlighted advances in optical genome mapping through twelve studies presented at ACMG 2026. Hosted the Bionano Symposium 2026 with robust attendance, drawing more than 1,250 registrants across nearly 35 external presentations from 33 different presenters, spanning hematologic malignancies, oncology research, bioprocessing applications, and constitutional genetic disorder research, with leading institutions describing automation of OGM workflows and plans to scale to thousands of samples per year. 2026 Outlook We anticipate the following results for Q2 and the full year 2026: Q2 2026 revenue guidance in the range of $7.5 to $7.8 million. Full year 2026 revenue guidance in the range of $30 to $33 million. Webcast Details Date: Wednesday, May 13, 2026 Time: 4:30 p.m. Eastern Time Participant Registration: Registration – Click Here Webcast: Registration – Click Here Participants should register at the link above in advance of the call, and then click the webcast link before the call begins. An archived version of the webcast will be available for replay in the Investors section of the Bionano website. 1 “Adjusted gross margin” and “adjusted operating expense” are non-GAAP financial measures. Please refer to the section titled “Adjusted Financial Measures” below for a description of the adjusted financial measures used herein. Reconciliations of adjusted financial measures to the most directly comparable GAAP financial measures are included in the financial tables accompanying this release. About Bionano Bionano is a provider of genome analysis solutions that can enable researchers and clinicians to reveal answers to challenging questions in biology and medicine. The Company’s mission is to transform the way the world sees the genome through optical genome mapping (OGM) solutions, diagnostic services and software. The Company offers OGM solutions for applications across basic, translational and clinical research. The Company also offers an industry-leading, platform-agnostic genome analysis software solution, and nucleic acid extraction and purification solutions using proprietary isotachophoresis (ITP) technology. Through its Lineagen, Inc. d/b/a Bionano Laboratories business, the Company also offers OGM-based diagnostic testing services. For more information, visit  or  . Bionano’s products are for research use only and not for use in diagnostic procedures. Adjusted Financial Measures Note: Effective with the fiscal period ended March 31, 2026, the Company renamed certain of its non-GAAP financial measures. Measures previously reported as "non-GAAP gross margin," "non-GAAP operating expense," and other titles using "non-GAAP" are now presented as "adjusted gross margin," "adjusted operating expense," and similar designations, respectively. These title changes are intended solely to simplify the Company’s presentation and align with the nomenclature commonly used by the Company’s peers. The definitions, methodologies, and components underlying each of these measures remain unchanged from prior periods, and no adjustments have been made to the items included in, or excluded from, the calculation of any such measure on account of the title changes. Prior-period amounts and descriptions have been recast to conform to the current-period presentation . To supplement Bionano’s financial results reported in accordance with U.S. generally accepted accounting principles (GAAP), the Company has provided adjusted gross margin and adjusted operating expense in this press release and the accompanying conference call, each of which is a adjusted financial measure. The most directly comparable GAAP measures to these adjusted financial measures are gross margin, cost of revenue, selling, general and administrative expense, research and development expense, intangible assets and other long-lived assets impairment, restructuring costs and operating expense, each as reported in accordance with GAAP. Adjusted gross margin excludes from gross margin reported in accordance with GAAP: stock-based compensation. Adjusted operating expense excludes from operating expense reported in accordance with GAAP: stock-based compensation, amortization of intangibles, and transaction-related expenses. In addition, our reconciliation table provided at the end of this release contains certain additional adjusted metrics, including adjusted cost of revenue, adjusted selling, general and administrative expense, adjusted research and development expense, adjusted intangible assets and other long-lived assets impairment and adjusted restructuring costs, each with adjustments as presented in the table. Stock-based compensation and certain other items excluded from our adjusted financial measures are recurring expenses for us and are expected to continue in future periods. Bionano believes that each of these adjusted metrics is useful to investors and analysts as a supplement to its financial information prepared in accordance with GAAP for analyzing the Company’s performance and identifying trends in its business. Bionano uses these adjusted metrics internally to facilitate period-to-period comparisons and analysis of its performance in order to understand, manage and evaluate its business, to make operating decisions, and for forecasting and budgeting. Accordingly, Bionano believes presentation of these adjusted measures allows for greater transparency with respect to key financial metrics it uses in assessing its own operating performance and making operating decisions. These adjusted financial measures are not meant to be considered in isolation or as a substitute for comparable GAAP measures; should be read in conjunction with the Company’s consolidated financial statements prepared in accordance with GAAP; have no standardized meaning prescribed by GAAP; and are not prepared under any comprehensive set of accounting rules or principles. In addition, from time to time in the future, there may be other items that the Company may exclude for purposes of its adjusted financial measures; and the Company may in the future cease to exclude items that it has historically excluded for purposes of its adjusted financial measures. Likewise, the Company may determine to modify the nature of its adjustments to arrive at its adjusted financial measures. Because of the non-standardized definitions of adjusted financial measures, each adjusted financial measure as used by Bionano in this press release and the accompanying reconciliation table has limits in its usefulness to investors and may be calculated differently from, and therefore may not be directly comparable to, similarly titled measures used by other companies. For a reconciliation of adjusted gross margin to gross margin reported in accordance with GAAP and adjusted operating expense to operating expense reported in accordance with GAAP, please refer to the financial tables accompanying this press release. Forward-Looking Statements of Bionano Genomics This press release and the accompanying conference call contains forward-looking statements within the meaning of the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. All statements other than statements of historical facts contained in this press release, including statements regarding our future results of operations or financial condition, business strategy and plans, and objectives of management for future operations, are forward-looking statements. Words such as “anticipate,” “believe,” “could,” “estimate,” “expect,” “intend,” “may,” “plan,” “potential,” “predict,” “project,” “should,” “target,” “will,” or “would” and similar expressions (as well as other words or expressions referencing future events, conditions or circumstances) convey uncertainty of future events or outcomes and are intended to identify forward-looking statements. Forward-looking statements include statements regarding our intentions, beliefs, projections, outlook, analyses or current expectations concerning, among other things: our expectations regarding market adoption of our products; our commercial prospects and future financial and operating results; and our ability to meet our stated goals and commercial opportunities, including our full year and first quarter 2026 guidance. Each of these forward-looking statements involves risks and uncertainties. Accordingly, investors and prospective investors are cautioned not to place undue reliance on these forward-looking statements as they involve inherent risk and uncertainty (both general and specific) and should note that they are provided as a general guide only and should not be relied on as an indication or guarantee of future performance. There are a number of important factors that could cause the actual results to differ materially from those expressed in any forward-looking statement made by us. These factors include, but are not limited to: our ability to improve our margins, extend our cash runway and reach a potential pathway to profitability; our ability to retire our debt at maturity; our ability to continue as a going concern as disclosed in our filings with the SEC which requires us to manage costs and obtain significant additional financing to fund our strategic plans and commercialization efforts; our ability to execute on our strategy and achieve our objectives; the impact and utility of our cost savings initiative and our recent financing; our ability to continue to drive OGM (as defined above) adoption by potential customers for routine use in genomic analysis; the impact, or lack thereof, of Category I CPT codes to accelerate or increase the adoption of OGM; continued research, presentations and publications involving OGM and its utility compared to traditional cytogenetics and our technologies; the impact of our Stratys™ system and VIA™ software to increase throughput and simplify analysis of OGM data; our ability to drive adoption of OGM and our technology solutions; our ability to further deploy new products and applications for our technology platforms; our expectations and beliefs regarding future growth of the business and the markets in which we operate; our ability to consummate any strategic alternatives including the risk that if we fail to obtain additional financing we may seek relief under applicable insolvency laws; the size and growth potential of the markets for our products, and our ability to serve those markets; the rate and degree of market acceptance of our products; our ability to manage the growth of our business and integrate acquired businesses; our ability to expand our commercial organization to address effectively existing and new markets that we intend to target; the impact from future regulatory, judicial, and legislative changes or developments in the U.S. and foreign countries; our ability to compete effectively in a competitive industry; the introduction of competitive technologies or improvements in existing technologies and the success of any such technologies; the performance of our third-party contract sales organizations, suppliers and manufacturers; our ability to attract and retain key scientific or management personnel; the accuracy of our estimates regarding expenses, future revenues, reimbursement rates, capital requirements and needs for additional financing; the impact of adverse geopolitical and macroeconomic developments, such as recent and future bank failures, ongoing international conflicts, and related sanctions, regional or global pandemics, inflation, tariffs, increased cost of goods, supply chain issues, and global financial market conditions on our business and operations, as well as the business or operations of our suppliers, customers, manufacturers, research partners and other third parties with whom we conduct business and our expectations with respect to the duration of such impacts and the resulting effects on our business; our ability to realize the anticipated benefits and synergies of our prior and any future acquisitions or other strategic transactions; our ability to attract collaborators and strategic partnerships; and the risks and uncertainties associated with our business and financial condition in general, including the risks and uncertainties described in our filings with the Securities and Exchange Commission (“SEC”), including, without limitation, our Annual Report on Form 10-K for the year ended December 31, 2025, any subsequently filed Quarterly Reports on Form 10-Q and in other filings subsequently made by us with the SEC. All forward-looking statements contained in this press release speak only as of the date on which they were made and are based on management’s assumptions and estimates as of such date. We do not undertake any obligation to publicly update any forward-looking statements, whether as a result of the receipt of new information, the occurrence of future events or otherwise, except as may be required by law. CONTACT Investor Relations: Webb Campbell Gilmartin Group +1 (415) 520-5817 IR@bionano.com Bionano Genomics, Inc. Condensed Consolidated Balance Sheet (Unaudited) (Unaudited) March 31, 2026 December 31, 2025 Assets Current assets: Cash and cash equivalents $ 3,425 $ 2,990 Investments 10,980 16,279 Accounts receivable, net 4,133 5,200 Inventory 5,307 5,448 Prepaid expenses and other current assets 4,864 5,203 Restricted investments 10,266 10,266 Total current assets 38,975 45,386 Property and equipment, net 14,040 14,847 Operating lease right-of-use asset 3,062 3,217 Financing lease right-of-use asset 3,044 3,095 Intangible assets, net 3,005 4,345 Other long-term assets 2,678 2,694 Total assets $ 64,804 $ 73,584 Liabilities and stockholders’ equity Current liabilities: Accounts payable $ 5,062 $ 5,590 Accrued expenses 3,996 5,460 Contract liabilities 1,126 967 Operating lease liability 646 697 Finance lease liability 246 249 Convertible debentures and High Trail notes payable (at fair value) 10,152 9,979 Total current liabilities 21,228 22,942 Operating lease liability, net of current portion 2,507 2,489 Finance lease liability, net of current portion 3,463 3,480 Long-term contract liabilities 143 249 Total liabilities 27,341 29,160 Stockholders’ equity: Preferred stock — — Common stock 1 1 Additional paid-in capital 765,373 764,026 Accumulated deficit (727,923 ) (719,620 ) Accumulated other comprehensive income (loss) 12 17 Total stockholders’ equity 37,463 44,424 Total liabilities and stockholders’ equity $ 64,804 $ 73,584 Bionano Genomics, Inc. Condensed Consolidated Statement of Operations (Unaudited) Three Months Ended March 31, 2026 2025 Revenue: Product revenue $ 6,094 $ 6,004 Service and other revenue 593 453 Total revenue 6,687 6,457 Cost of revenue: Cost of product revenue 3,205 3,053 Cost of service and other revenue 230 466 Total cost of revenue 3,435 3,519 Operating expenses: Research and development 3,139 2,370 Selling, general and administrative 8,010 9,033 Total operating expenses 11,149 11,403 Loss from operations (7,897 ) (8,465 ) Other income (expenses): Interest income 223 290 Other income (expense) (619 ) 5,080 Total other income (expense) (396 ) 5,370 Loss before income taxes (8,293 ) (3,095 ) Provision for income taxes (10 ) (7 ) Net loss $ (8,303 ) $ (3,102 ) Bionano Genomics, Inc. Reconciliation of GAAP to Adjusted Financial Measures (Unaudited) Three Months Ended March 31, 2026 2025 GAAP gross margin: GAAP revenue $ 6,687 $ 6,457 GAAP cost of revenue 3,435 3,519 GAAP gross profit 3,252 2,938 GAAP gross margin % 49 % 46 % Adjusted gross margin: GAAP revenue $ 6,687 $ 6,457 GAAP cost of revenue 3,435 3,519 Stock-based compensation expense (31 ) (37 ) Adjusted cost of revenue 3,404 3,482 Adjusted gross profit 3,283 2,975 Adjusted gross margin % 49 % 46 % GAAP operating expense GAAP selling, general and administrative expense $ 8,010 $ 9,033 Stock-based compensation expense (561 ) (1,300 ) Intangible asset amortization (1,340 ) (1,340 ) Transaction related expenses (100 ) (63 ) Adjusted selling, general and administrative expense 6,009 6,330 GAAP research and development expense $ 3,139 $ 2,370 Stock-based compensation expense (78 ) (250 ) Adjusted research and development expense 3,061 2,120 Total adjusted operating expense $ 9,070 $ 8,450

Scientists at McGill University have uncovered a hidden molecular “switch” that turns on a powerful calorie-burning system in brown fat — the body’s heat-generating fat linked to metabolism and weight control. The breakthrough centers on glycerol, a molecule released when fat is broken down in the cold, which activates an enzyme called TNAP and triggers an alternative heat-producing pathway that scientists had struggled to explain for years.Scientists have uncovered a molecular "switch" in mice that turns on a hidden energy-burning system inside brown fat, a discovery that could eventually help researchers develop new treatments for bone disease. The findings, published in Nature, provide new insight into how brown fat works. Unlike white fat, which stores energy, brown fat burns calories to generate heat. Scientists long believed this heat production depended on a single biological pathway. In recent years, however, researchers identified a second pathway operating alongside the original one, but they did not know what activated it. A team led by Lawrence Kazak at McGill University's Rosalind and Morris Goodman Cancer Institute has now identified the molecular trigger for this alternative system, known as the futile creatine cycle. Scientists Identify Brown Fat "On Switch" When the body is exposed to cold temperatures, it breaks down stored fat to create heat. That process releases glycerol, a molecule produced during fat metabolism. Working with McGill structural biologist Alba Guarné, Canada Research Chair in Macromolecular Machines in DNA Damage and Repair, the researchers discovered that glycerol binds to an enzyme called TNAP in a region they describe as the glycerol pocket. This interaction activates the alternative heat-producing pathway. "This is the first time we've identified how an alternative heat-producing pathway is activated, independent of the classic system," said Kazak, Associate Professor in the Department of Biochemistry and the Canada Research Chair in Adipocyte Biology. "That opens the door to understanding how multiple energy-burning systems work together to keep the body warm at the just-right temperature." Discovery May Advance Bone Disease Research Brown fat has attracted attention for its possible role in metabolism and obesity research. While the new findings could eventually contribute to those areas, the researchers say the most immediate significance may involve bone health because TNAP already has a well-established role in bone formation. The TNAP enzyme is essential for calcification, the process that builds and maintains strong bones. Mutations that reduce TNAP activity can cause hypophosphatasia, a rare disorder sometimes called "soft bones." The condition can lead to fractures, chronic pain, and skeletal abnormalities. Certain inherited mutations have made the disorder more common in parts of Canada, including Quebec and Manitoba. By studying TNAP mutations in laboratory experiments, the scientists discovered that the same molecular switch involved in energy-burning fat cells also directly affects cells responsible for bone mineralization and hardening. The work builds on earlier research by McGill co-author Marc McKee and co-author José-Luis Millán of the Sanford Burnham Prebys Medical Discovery Institute. Their previous efforts helped produce a first-in-class enzyme replacement therapy designed specifically for hypophosphatasia patients with defective TNAP enzymes. "This finding opens the door to a new kind of treatment, where increasing the activity of the TNAP enzyme through its glycerol pocket by natural or synthetic bioactive compounds could potentially boost the beneficial actions of the enzyme in patients, to help restore deficient bone mineralization to healthy levels," said McKee, Professor in the Faculty of Dental Medicine and Oral Health Sciences and the Faculty of Medicine and Health Sciences, and Canada Research Chair in Biomineralization. Researchers have already identified dozens of possible drug candidates for future investigation. About the Study The study, "Glycerol-driven TNAP activation in thermogenesis and mineralization," by Mohammed Faiz Hussain, Lawrence Kazak et al., was published in Nature. The project included collaborations with scientists from Queen Mary University of London, Northeastern University, the Sanford Burnham Prebys Medical Discovery Institute, and the Maine Health Institute for Research. Funding came from the Canadian Institutes of Health Research, the Natural Sciences and Engineering Research Council of Canada, and the Fonds de recherche du Québec -- Santé.

LA JOLLA, Calif., May 5, 2026 /PRNewswire/ -- Sanford Burnham Prebys Medical Discovery Institute today announced that Andrew Viterbi, a visionary communications pioneer and co-founder of Qualcomm Inc., has made a $5 million gift to endow the Andrew and Erna Viterbi Distinguished Chair in the Center for Data Science and Artificial Intelligence at Sanford Burnham Prebys. Continue Reading Andrew Viterbi The Center for Data Science and Artificial Intelligence brings together experts in AI, statistics, genetics and more to probe raw or untapped data to uncover patterns and insights that can inform scientists and clinicians, sparking innovation and scientific breakthroughs for new possibilities for human health. The center recently introduced an advanced computational biology tool that automates and standardizes genome sequencing analysis, enabling scientists to decipher the entire genomes of many patient samples, animal models or cultured cells in a single experiment. "I hold deep confidence in the strength of the leadership at Sanford Burnham Prebys to steward this investment with vision and purpose," said Andrew Viterbi. "Biomedical research and collaboration generate momentum used to advance computing and artificial intelligence. It's my hope that this gift will enable the Center for Data Science and AI to empower leading minds to create the breakthroughs that will advance human health." The inaugural holder of the chair will be Yuk-Lap (Kevin) Yip, PhD, director of the Center for Data Science and Artificial Intelligence, and a globally recognized leader in computational biology and bioinformatics. Dr. Yip's pioneering work harnesses advanced analytics and machine learning to uncover insights from complex biological data, accelerating progress in disease research and precision medicine. This investment by Dr. Viterbi, a distinguished philanthropist whose generosity has advanced engineering, higher education, medical research and the arts, reflects his enduring commitment to innovation and discovery, and his belief in the power of interdisciplinary science to address some of the most complex challenges in human health. Dr. Viterbi's gift will further strengthen Sanford Burnham Prebys' leadership in biomedical research powered by artificial intelligence. Viterbi is no stranger to innovation or to pushing technological boundaries. He is a co-founder and retired vice chairman and chief technical officer of Qualcomm Inc., and renowned for inventing the "Viterbi Algorithm," a dynamic programming method that finds the most likely sequence of hidden events that would explain a sequence of observed events. "Andrew has been a force, pairing extraordinary intellect with a deep commitment to advancing human knowledge and possibility," said David Brenner, MD, president and CEO of Sanford Burnham Prebys. "With this remarkable gift, he is investing in the bold vision of our Center for Data Science and AI where world-class scientists are redefining how we understand biology and disease. Together, we are unlocking the power of artificial intelligence to drive discoveries at a scale and speed once unimaginable, and to shape the future of medicine for generations to come." Through this endowed chair, Sanford Burnham Prebys will continue to attract and support world-class scientific talent, advancing breakthrough discoveries at the intersection of data science, artificial intelligence and human health poised to redefine the future of medicine. About Sanford Burnham Prebys: Celebrating its 50th anniversary, Sanford Burnham Prebys Medical Discovery Institute is an independent nonprofit biomedical research institute dedicated to understanding the fundamental biology of human health and disease and translating discoveries into advances that improve lives. Sanford Burnham Prebys has four disease-focused centers: NCI-designated Cancer Center; Center for Cardiovascular and Muscular Diseases; Center for Neurologic Diseases; and Center for Metabolic and Liver Diseases; as well as two enabling technology centers: Center for Data Science and Artificial Intelligence and Center for Therapeutics Discovery. The Institute's scientists have driven breakthroughs across cancer, neuroscience and aging, as well as diseases of the heart, muscle, metabolism and liver. Our research is strengthened by drug discovery capabilities, data science and artificial intelligence and global collaborations that help move discoveries toward real-world impact. A strong culture of collaboration, paired with a commitment to education through our graduate school to train the next generation of scientists, brings together researchers, partners and philanthropists in a shared mission to advance biomedical science and improve human health. Learn more at sbpdiscovery.org. SOURCE Sanford Burnham Prebys Medical Discovery Institute 21% more press release views with Request a Demo