BACKGROUNDResearch on the function of HGH1 in breast cancer remains lacking.METHODSTCGAand GEO (GSE45827) datasets investigated discrepancies in HGH1 expression in BC. An aggregate of 106 clinical samples were gathered through immunohistochemistry, KM curves were drawn for prognostic analysis, and the function of HGH1 of BC was predicted. Finally, the effects of HGH1 knockdown on MDA-MB-231 and MCF-7 BC cells were verified via CCK8, invasion, wound healing and colony formation assays.RESULTSHGH1 is highly expressed in BC and is linked to unfavorable prognosis. HGH1 overexpression is connected to keratinization and the cell cycle and is closely related to ER and PR expression and tumor stage in BC patients. Knocking down HGH1 in BC cells inhibited the viability, invasion and migration.CONCLUSIONKnockdown of HGH1 in breast cancer cell lines can inhibit the viability, invasion and migration of tumor cells.

31 Dec 2025·Drug Delivery

Advanced hydrogel material for colorectal cancer treatment

Author: Zhao, Zeyun ; Zhang, Yuzhong ; Wang, Min ; Li, Jiannan ; Guo, Yu

Colorectal cancer is one of the most common cancers worldwide, and its incidence rates are increasing every year.Treatments for CRC include surgical resection, chemotherapy, radiotherapy, targeted therapy, and immunotherapy.Although various agents have been used in the treatment of malignant tumors, they are not as effective as expected.This is primarily owing to the lack of selectivity, poor solubility, and severe side effects of most agents.It is necessary to develop more efficient drug delivery systems for the precise targeting of the tumor site and effective therapeutic effects to meet clin. needs.A hydrogel is a three-dimensional network material composed of crosslinked side chains of hydrophilic or hydrophobic groups and a polymer backbone.Hydrogels possess useful properties including high water content, adjustable phys. characteristics, elasticity, flexibility, reversible swelling, and multifunctionality.These properties render them ideal biomaterials with a broad range of applications in biomedicine and bioengineering.In this review, we introduce the pathophysiol. and current therapeutic advances in CRC and summarize the applications of hydrogels composed of different materials as well as smart response hydrogels as drug carriers in CRC treatment.We also analyze the unique advantages and challenges of using hydrogels as targeted drug delivery carriers in tumor therapy.

01 May 2025·Neural Regeneration Research

Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

Article

Author: Han, Qi ; Wang, Ying ; Ding, Ying ; Sun, Yan ; Chen, Chen ; Wu, Wei ; Smith, George ; Wu, Xiangbing ; Li, Rui ; Xu, Xiao-Ming ; Qu, Wenrui ; Liu, Nai-Kui ; Xia, Yongzhi ; Dai, Heqiao ; Walker, Melissa ; Deng, Lingxiao

JOURNAL/nrgr/04.03/01300535-202505000-00029/figure1/v/2024-07-28T173839Z/r/image-tiff Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties. A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury. A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity, and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar, thus limiting axonal reentry into the host spinal cord. Here we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord injury. We report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders, Schwann cells migrated for considerable distances in both rostral and caudal directions. Such Schwann cell migration led to enhanced axonal regrowth, including the serotonergic and dopaminergic axons originating from supraspinal regions, and promoted recovery of locomotor and urinary bladder functions. Importantly, the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury, even when treatment was delayed for 3 months to mimic chronic spinal cord injury. These findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

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