Xuzhou Central Hospital

Poly(lactic acid) (PLA)-based nanofibrous membranes (NFMs) have significant potential for use in biodegradable filters for air purification, but their application is often limited by relatively poor electret properties.Herein, tree-inspired gradient PLA (TG-PLA) nanofibers with biomimetic surfaces and remarkable electroactivity were fabricated by coaxial electrospinning of a unique core-shell structure.Importantly, the bioinspired structure conferred dramatic increase of dielec. constant for TG-PLA NFMs by 218%, as well as enhanced in situ electret properties (over 3-fold rise of surface potential).The well-controlled morphol. features and increased electroactivity contributed synergistically to distinct promotion of active PM-capturing performance, as exemplified by 99.25% filtration of PM_0.3 at the airflow velocity of 32 L/min for TG-PLA2, largely surpassing the counterpart (only 89.63%).Benefiting from the significantly increased electroactivity, TG-PLA2 exhibited superior energy harvesting performance and long-term stability (output voltage of 44.7 V, over 2000-s cycle test).Furthermore, a convolutional neural network (CNN) algorithm was developed to establish an intelligent respiratory recognition system, demonstrating high-accuracy diagnosis of multiple complex scenarios.The exceptional promotion in the surface activity and intrinsic electroactivity for PLA nanofibers is of enormous potential for environmental applications.Our bioinspired strategy can lead to a versatile platform that integrates with profound property improvements and scale-up feasibility for intelligent protective membranes.

To investigate the clinical feasibility, efficacy and safety of a suture technique combining annulus fibrosus with posterior longitudinal ligament under full endoscopy in patients with lumbar disc herniation.

Retrospective case-control study. A total of 412 patients with lumbar disc herniation treated in our hospital from January 2020 to November 2022 were enrolled and analyzed. There were 208 males and 204 females, aged from 26 to 54 years old(average 39.9 ± 5.1). 208 patients were treated with combining annulus fibrous suture with posterior longitudinal ligament after percutaneous lumbar discectomy(PELD) (observation group)0.204 patients were treated with percutaneous lumbar discectomy(PELD) alone(control group). Operation time, blood loss, Visual Analogue scale(VAS), Oswestry disability index(ODI),Japanese Orthopedic Association(JOA), modified MacNab criteria and imaging examination were used to evaluate.

All the 412 patients successfully completed the surgery. Complete follow-up time was 12-18 months, with an average of 15.2 ± 1.6 months. Postoperative symptoms were all significantly relieved. There was no statistically significant difference in baseline data between groups (P > 0.05). The scores of VAS,ODI and JOA at different postoperative follow-up visits were significantly lower than those before surgery (P < 0.05). There was significant difference in each group before and after surgeries (P < 0.05). The postoperative recurrence rates and reoperation rates between groups were significant different(P < 0.05). According to MacNab, the excellent and good rate was 96.2 % (200/208) in observation group and 90.7 % (185/204) in control group(P < 0.05).

The suture technique combining annulus fibrosus with posterior longitudinal ligament under full endoscopy in patients with lumbar disc herniation has satisfactory short- and mid-term clinical effect,and can effectively reduce postoperative recurrence rate, which is a safe and ideal suture technique for annulus fibrosus rupture.

not applicable.

Wound infections are a growing public health issue, worsened by drug-resistant strains. Quercetin (Que) has shown anti-inflammatory, antioxidant, and antimicrobial properties, but its limited bioavailability hinders therapeutic use. This study introduces a multifunctional self-assembly nanoplatform, QHCNPs, encapsulating quercetin with hordein/chitosan to enhance stability and bioavailability. Transmission electron microscopy and particle size analysis revealed that QHCNPs are spherical structures with a diameter of 435.5 ± 2.9 nm and a Zeta potential of +11.0 mV. QHCNPs demonstrated excellent stability, low cytotoxicity, and MIC values of 512 ppm against Staphylococcus aureus (S. aureus) and 256 ppm against methicillin-resistant Staphylococcus aureus (MRSA). In a bacterial wound model, QHCNPs outperformed quercetin alone by accelerating wound healing, eliminating bacteria, reducing inflammatory markers, scavenging reactive oxygen species (ROS), and promoting collagen and blood vessel regeneration. These results establish QHCNPs as a promising non-antibiotic therapy for treating drug-resistant wound infections, supporting further exploration for clinical applications.