Delving into the Latest Updates on Universidad Austral de Chile with Synapse

Overview

Tags

Respiratory Diseases

Infectious Diseases

Nanobody

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Infectious Diseases	1

Top 5 Drug Type	Count

Nanobody	1

Top 5 Target	Count

SARS-CoV-2 S protein	1

The goal of this clinical trial is to evaluate the efficacy of a mobile phone application for the early intervention of depression and anxiety among young university students in Chile. The main question it aims to answer is:
- Can a mobile app reduce depressive and anxious symptomatology in college students?
Researchers will compare the intervention arm (mobile app users) to the control group (receives psychoeducational material and mental health care resources) to see if the app leads to significant improvements in depressive and anxious symptoms and well-being.
Participants will:
* Be randomly assigned to either the intervention or control group.
* Use the mobile application, which includes psychoeducational materials, cognitive-behavioral therapy modules, and periodic personalized feedback.
* Complete assessments at baseline, post-intervention, and 3 and 6 months after randomization using online tools such as the PHQ-9 for depressive symptoms and the GAD-7 for anxious symptoms.

Start Date23 May 2024

Sponsor / Collaborator

University of Chile

[+3]

ISRCTN15884989 / RecruitingNot ApplicableIIT

Application of an intervention based on mindfulness in secondary education. Impact on teaching-learning processes and on the promotion of mental health and well-being of teachers and students

Start Date28 Apr 2022

Sponsor / Collaborator

Universidad Austral de Chile

ISRCTN34932978 / CompletedNot ApplicableIIT

Tridimensional alveolar ridge preservation after exodontia with leukocyte- and platelet-rich fibrin (L-PRF): A split-mouth randomized clinical trial

Start Date01 Apr 2019

Sponsor / Collaborator

Universidad Austral de Chile

100 Clinical Results associated with Universidad Austral de Chile

Login to view more data

0 Patents (Medical) associated with Universidad Austral de Chile

Login to view more data

12,980

Literatures (Medical) associated with Universidad Austral de Chile

31 Dec 2024·Systematics and Biodiversity

A hint on the unknown diversity of eastern Andes: high endemicity and new species of mammals revealed through DNA barcoding

Author: Aleixo, Alexandre ; Sánchez-Vendizú, Pamela Y. ; Pacheco, Víctor ; Leo, Mariela ; Batista, Romina ; Abreu, Edson F. ; Murta-Fonseca, Roberta A. ; Pradel, Renzo ; Peloso, Pedro ; Pavan, Silvia E. ; Percequillo, Alexandre R. ; Rengifo, Edgardo M.

01 Nov 2024·The American Journal of the Medical Sciences

Sodium tungstate (NaW) decreases inflammation and renal fibrosis in diabetic nephropathy

Article

Author: Silva, Pamela ; Sandoval, Moises ; Yáñez A, Mariana ; Yañez, Alejandro J ; Aguilar, Marcelo ; Jaramillo, Karen ; Carpio, Daniel

BACKGROUNDDiabetic Nephropathy is one of the most severe complications of Diabetes Mellitus and the main cause of end-stage kidney disease worldwide. Despite the therapies available to control blood glucose and blood pressure, many patients continue to suffer from progressive kidney damage. Chronic hyperglycemia is the main driver of changes observed in diabetes; however, it was recently discovered that inflammation and oxidative stress contribute to the development and progression of kidney damage. Therefore, it is important to search for new pharmacological therapies that stop the progression of DN. Sodium tungstate (NaW) is an effective short and long-term antidiabetic agent in both type 1 and type 2 diabetes models.METHODSIn this study, the effect of NaW on proinflammatory signalling pathways, proinflammatory proteins and fibrosis in the streptozotocin (STZ)-induced type 1 diabetic rat model was analysed using histological analysis, western blotting and immunohistochemistry.RESULTSNaW treatment in diabetic rats normalize parameters such as glycemia, glucosuria, albuminuria/creatinuria, glomerular damage, and tubulointerstitial damage. NaW decreased the proinflammatory signaling pathway NF-κB, inflammatory markers (ICAM-1, MCP-1 and OPN), profibrotic pathways (TGFβ1/Smad2/3), reduced epithelial-mesenchymal transition (α -SMA), and decreased renal fibrosis (type IV collagen).CONCLUSIONNaW could be an effective drug therapy for treating human diabetic nephropathy.

01 Nov 2024·Animal Feed Science and Technology

Increasing concentrations of low SMCO swedes in the diet of dairy cows improves performance and ruminal metabolism without affecting dairy cow health

Author: Pulido, R.G. ; Sepulveda-Varas, P. ; Berthiaume, R. ; Ríos, J.C. ; Sepúlveda-Varas, P. ; Rios, J. C. ; Pinto-Pinuer, R. ; Pacheco, D. ; Pulido, R. G. ; Balocchi, O.A. ; Vargas-Bello-Pérez, E. ; Keim, J. P. ; Keim, J.P. ; Balocchi, O. A. ; Vargas-Bello-Perez, E.

This study aimed to determine dry matter intake, ruminal fermentation, health-related blood metabolites, and production responses of early-lactation dairy cows fed two inclusion levels (30 and 45 %) of low SMCO swedes in the diet.Twelve pregnant multiparous lactating Holstein-Friesian dairy cows (24.1 ± 0.72 kg milk/d, 540 ± 7.3 kg BW, and 142 ± 3.9 DIM at the start of the study) were used in this study.Cows were randomly allocated to three dietary treatments in a replicated 3 x3 Latin square design.The experiment lasted 63 d and was divided into three 21-d periods.Inclusion of swedes at 30 and 45 % in the diet had no effect on DMI, but increased milk, protein and fat yields, as well as CP concentration in milk.This was due to changes in VFA patterns with greater molar proportions of propionate and butyrate, as well as a greater utilization of dietary N that was converted to microbial N.No neg. effects on haematol. and biochem. blood parameters, except for increased BHB concentrationsFatty acids composition in milk was modified, with a greater proportion of saturated FA and lower n-3 FA.Overall, low SMCO swedes can be included up to 45 % in the diet of pasture fed dairy cows during winter.

100 Deals associated with Universidad Austral de Chile

Login to view more data

100 Translational Medicine associated with Universidad Austral de Chile

Login to view more data

Corporation Tree

Boost your research with our corporation tree data.

login

or

view full example data

Boost your research with our corporation tree data.

Pipeline

Pipeline Snapshot as of 23 Dec 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

1

Other

Login to view more data