Delving into the Latest Updates on Fuzhou University with Synapse

Overview

Tags

Neoplasms

Digestive System Disorders

Hemic and Lymphatic Diseases

Small molecule drug

Chemical drugs

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Neoplasms	2
Hemic and Lymphatic Diseases	1

Top 5 Drug Type	Count

Small molecule drug	1
Chemical drugs	1

Top 5 Target	Count

caspase 3(Caspase-3)	1

主要目的：评价福大赛因注射液对于改善食管阻塞和吞咽困难症状的疗效。次要目的：评价福大赛因注射液治疗前后肿瘤病灶缩小情况；评价福大赛因注射液治疗前后生活质量改善情况；评价福大赛因注射液治疗的安全性及潜在操作风险的控制。

[Translation]

Primary objective: To evaluate the efficacy of Fosdaigin injection in improving esophageal obstruction and dysphagia. Secondary objectives: To evaluate the reduction of tumor lesions before and after Fosdaigin injection treatment; to evaluate the improvement of quality of life before and after Fosdaigin injection treatment; to evaluate the safety of Fosdaigin injection treatment and the control of potential operational risks.

Start Date08 Oct 2016

Sponsor / Collaborator

Fuzhou University

[+1]

NCT01043016 / Unknown statusPhase 1

Safety Study of Photodynamic Therapy Using Photocyanine Injection in Treating Patients With Malignant Tumors

The purpose of this study is to determine the safety and maximum tolerated dose of Photocyanine injection in photodynamic therapy of malignant tumor (especially skin cancer and esophageal cancer).
Projected accrual: A total of 18-24 patients will be accrued for this study.

Start Date01 Mar 2009

Sponsor / Collaborator

Fujian Longhua Pharmaceutical Co., Ltd.

[+2]

100 Clinical Results associated with Fuzhou University

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0 Patents (Medical) associated with Fuzhou University

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40,385

Literatures (Medical) associated with Fuzhou University

01 Apr 2025·Journal of Environmental Sciences

Occurrence and potential risks of organophosphate esters in agricultural soils: A case study of Fuzhou City, Southeast China

Article

Author: Wang, Tao ; Guo, Hangting ; Zhang, Hong ; Tong, Ping ; Huang, Chong ; Zhou, Hanlin ; Ben, Yujie ; Zhang, Yong ; Han, Yonghe

Fifty agricultural soil samples collected from Fuzhou, southeast China, were first investigated for the occurrence, distribution, and potential risks of twelve organophosphate esters (OPEs). The total concentration of OPEs (ΣOPEs) in soil ranged from 1.33 to 96.5 ng/g dry weight (dw), with an average value of 17.1 ng/g dw. Especially, halogenated-OPEs were the predominant group with a mean level of 9.75 ng/g dw, and tris(1-chloro-2-propyl) phosphate (TCIPP) was the most abundant OPEs, accounting for 51.1% of ΣOPEs. The concentrations of TCIPP and ∑OPEs were found to be significantly higher (P < 0.05) in soils of urban areas than those in suburban areas. In addition, the use of agricultural plastic films and total organic carbon had a positive effect on the occurrence of OPE in this study. The positive matrix factorization model suggested complex sources of OPEs in agricultural soils from Fuzhou. The ecological risk assessment demonstrated that tricresyl phosphate presented a medium risk to land-based organisms (0.1 ≤ risk quotient < 1.0). Nevertheless, the carcinogenic and non-carcinogenic risks for human exposure to OPEs through soil ingestion and dermal absorption were negligible. These findings would facilitate further investigations into the pollution management and risk control of OPEs.

01 Feb 2025·Biomaterials

Nanoscale octopus guiding telomere entanglement: An innovative strategy for inducing apoptosis in cancer cells

Article

Author: Lu, Chunhua ; Cao, Xiuping ; Bai, Shiyan ; Liu, Yana ; Zhong, Wukun ; Li, Shiqing ; Zeng, Tao ; Fang, Liyang ; Yang, Huanghao ; Jiang, Yifan

Telomere length plays a crucial role in cellular aging and the risk of diseases. Unlike normal cells, cancer cells can extend their own survival by maintaining telomere stability through telomere maintenance mechanism. Therefore, regulating the lengths of telomeres have emerged as a promising approach for anti-cancer treatment. In this study, we introduce a nanoscale octopus-like structure designed to induce physical entangling of telomere, thereby efficiently triggering telomere dysfunction. The nanoscale octopus, composed of eight-armed PEG (8-arm-PEG), are functionalized with cell penetrating peptide (TAT) to facilitate nuclear entry and are covalently bound to N-Methyl Mesoporphyrin IX (NMM) to target G-quadruplexes (G4s) present in telomeres. The multi-armed configuration of the nanoscale octopus enables targeted binding to multiple G4s, physically disrupting and entangling numerous telomeres, thereby triggering telomere dysfunction. Both in vitro and in vivo experiments indicate that the nanoscale octopus significantly inhibits cancer cell proliferation, induces apoptosis through telomere entanglement, and ultimately suppresses tumor growth. This research offers a novel perspective for the development of innovative anti-cancer interventions and provides potential therapeutic options for targeting telomeres.

01 Feb 2025·Separation and Purification Technology

Selective adsorption of aldehyde impurities from propylene oxide using perethylated pillar[5]arene enabled by spatial size matching effect

Author: Qi, Zhaoyang ; Yin, Minlei ; Lin, Yuxin ; Huang, Shiyin ; Chen, Xuanjie ; Chen, Jie ; Qiu, Ting

Effective removal of acetaldehyde and propionaldehyde from propylene oxide is important for polyether industry but remains a significant challenge due to their similar mol. sizes and relatively close volatilities.Herein, we studied flexible mol. materials, perethylated pillar[n]arene crystals (n = 5, 6), which can be used to sep. acetaldehyde and propionaldehyde in propylene oxide.Through a space size matching effect, perethylated pillar[5]arene demonstrates excellent adsorption selectivity of 95 % and 100 % for aldehydes in ternary mixture and binary mixture of propylene oxide, acetaldehyde and propionaldehyde, resp.These impressive selective adsorption is achieved based on their differential host-guest interactions.D. functional theory calculations provide a comprehensive explanation of the adsorption process, revealing that the adsorption mechanisms of perethylated pillar[5]arene for acetaldehyde and propionaldehyde primarily involve C-H···O hydrogen bonding and C-H···π interactions.This study also provides a novel method for achieving one-step purification of propylene oxide in industrial applications.

100 Deals associated with Fuzhou University

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100 Translational Medicine associated with Fuzhou University

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Pipeline

Pipeline Snapshot as of 23 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

1

Phase 2 Clinical

Other

1

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Suftalan Zinc ( caspase 3 )	Esophageal Carcinoma More	Phase 2
FZU-03010	Acute Myeloid Leukemia More	Preclinical
Photocyanine ( caspase 3 )	Skin Neoplasms More	Discontinued