Jewim Pharmaceutical (Shandong) Co., Ltd

Objective To prepare single crystal of vortioxetine DL-lactate, and investigate the structure characterization.Methods Evaporation method was used to grow single crystals of vortioxetine DL-lactate, which were then characterized using thermal gravimetric analyzer(TGA), differential scanning calorimetry(DSC), Fourier transform IR spectrometer(IR), powder X-ray diffraction(PXRD), and single X-ray diffraction(SXRD).Results Single colorless block crystal of vortioxetine DL-lactate form βcould be obtained through acetonitrile evaporationDSC graph and PXRD spectrum was in good agreement with data reported in literatures.SXRD results showed that the unit stoichiometric of vortioxetine DL-lactate was C21 H28 N2 O3 S, and the relative mol. mass was 388.51, and crystal d. was 1.246 g/cm3.The unit cell belonged to a monoclinic system, and the space group was P21/c.Conclusion Crystal structure of vortioxetine DL-lactate is characterized by single X-ray diffraction, which provides a basis for the further development of vortioxetine DL-lactate.