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Endocrinology and Metabolic Disease

Small molecule drug

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A glimpse into the focused therapeutic areas

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Disease Domain	Count

Endocrinology and Metabolic Disease	1

Top 5 Drug Type	Count

Small molecule drug	1

Top 5 Target	Count

TNF-α(Tumor necrosis factor α)	1

This work aims to evaluate the effects of the association of green propolis extract with royal jelly on inflammation and oxidative stress in participants with chronic kidney diseases (CKD) and Systemic arterial hypertension (SAH), in a longitudinal, randomized, double-blind, placebo-controlled clinical trial that will be carried out for 2 months.

Start Date01 Oct 2024

Sponsor / Collaborator

Universidade Federal Fluminense

[+3]

NCT06705777

/ Active, not recruitingPhase 4IIT

Self-Paired Clinical Study of the Combination of Aesculus Hippocastanum 50 mg, Polygonum Acre 10 mg, Smilax Pepyracea 40 mg, Rutin 20 mg Tablets in Grade 1, 2 or 3 Hemorrhoidal Disease After 60 Days of Treatment

To demonstrate the clinical efficacy of the combination of Aesculus hippocastanum, Polygonum acre, Smilax Pepyracea, and rutin in tablets in improving local symptoms (bleeding, pain, thrombosis, perianal dermatitis, hemorrhoidal nipple prolapse) assessed using a 100mm visual scale (VAS) over 60 days among adult patients with grade 1, 2 or 3 hemorrhoidal disease.

Start Date01 Sep 2024

Sponsor / Collaborator

Fundação Educacional Serra dos Órgãos

[+2]

NCT06394544

/ Not yet recruitingNot ApplicableIIT

Effects of Brazil Nut Supplementation on Inflammation, Oxidative Stress and Microbiota in Patients With Chronic Kidney Disease Undergoing Conservative Treatment

The aim of this study is to evaluate the effects of Brazil nut supplementation on inflammation, oxidative stress and intestinal microbiota in patients with chronic kidney disease undergoing conservative treatment.

Start Date01 Aug 2024

Sponsor / Collaborator

Universidade Federal Fluminense

100 Clinical Results associated with Universidade Federal Fluminense

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0 Patents (Medical) associated with Universidade Federal Fluminense

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42,392

Literatures (Medical) associated with Universidade Federal Fluminense

31 Dec 2025·Annals of Medicine

Metabolic acidosis with elevated anion gap and euglycemic ketoacidosis in pregnant and postpartum women with severe Covid-19

Article

Author: Perlingeiro, Raissa de Moraes ; Pimentel, Clarisse ; Pinheiro Trindade, Priscila Martins ; Mendes da Silva, Wallace ; Caminha Escosteguy, Claudia ; Melo Mendes, Isabel Cristina ; Martins de Oliveira, Ana Luiza ; Galliez, Rafael Mello ; Melo Guedes, Cristiane

BACKGROUND/OBJECTIVESPregnant and postpartum women have a higher risk for developing severe Covid-19 and other clinical and obstetric complications. This study aims to evaluate the frequency of metabolic acidosis with elevated anion gap and describe a case series of euglycemic ketoacidosis (EKA) in pregnant and postpartum women with severe confirmed or suspected Covid-19.MATERIALS AND METHODSObservational retrospective study carried in a reference intensive care unit from May 2020 to June 2022. Cases were confirmed with positive RT-PCR or rapid antigen test. Cases with compatible clinical and radiologic findings were also included. Ketoacidosis was defined as the presence of metabolic acidosis with high anion gap (bicarbonate < 15 mEq/L and AG > 10 mEq/L) and ketonuria (2+ or more in urine test). Statistical analyses were made with R software.RESULTSOf 101 admissions, 61 (60.4%) presented metabolic acidosis with high anion gap. The median age was 29 years, and most were in the third trimester. Evolution to invasive mechanical ventilation (54.0%) and obstetric complications (78.0%) were frequent. The prevalence of metabolic acidosis with high anion gap and absence of hyperlactatemia was of 43.6% (44/101). Six (5.94%) women met the criteria for EKA. Despite severity, there were no deaths.CONCLUSIONSThe prevalence of metabolic acidosis and EKA in pregnant and postpartum women with severe Covid-19 was high. This condition should be routinely, so it can be promptly treated.

01 Dec 2025·Journal of Gastrointestinal Cancer

Anti-EGFR Rechallenge in Metastatic Colorectal Cancer and the Role of ctDNA: A Systematic Review and Meta-analysis

Review

Author: Saldanha, Erick Figueiredo ; da Silva, Marcos Vinícius Martins Grangeiro ; Peixoto, Renata D 'Alpino ; Noronha, Mariana Macambira ; da Silva, Luís Felipe Leite ; da Conceição, Lucas Diniz

BACKGROUNDMetastatic colorectal cancer (mCRC) remains a significant clinical challenge. While anti-EGFR inhibitors have improved survival rates, their long-term efficacy is limited by disease progression, which is often associated with the development of acquired resistance mutations. However, some patients may regain sensitivity to anti-EGFR agents after alternative therapies, suggesting a potential benefit for rechallenge strategies. Our study aims to conduct a systematic review and meta-analysis to comprehensively evaluate the efficacy and safety of EGFR rechallenge in patients with mCRC.METHODSA systematic search of the MEDLINE, EMBASE, and Cochrane databases was conducted between October 28 and December 24, 2023, to identify clinical trials investigating treatment regimens incorporating panitumumab or cetuximab as a rechallenge strategy. Pooled proportions or hazard ratios (HR) were calculated using a random effects model. Inter-study heterogeneity was assessed using the I².RESULTSAmong the 2105 articles identified through the search, 13 met the predetermined inclusion criteria. Of these, 12 were phase II studies, encompassing 92.3% of the patient population. Cetuximab was administered to 302 patients (75.1%), whereas panitumumab was utilized in 100 patients (24.9%).A pooled analysis of eight studies demonstrated an objective response rate of 20.50% (95% CI 7.94 to 33.07) and a disease control rate of 67.35% (95% CI 58.60 to 76.09). The median progression-free survival was estimated at 3.5 months (95% CI 2.68-6.69), with a median OS of 9.8 months (95% CI 6.71-12.89). Patients exhibiting RAS wild-type status in circulating tumor DNA (ctDNA) analysis derived enhanced benefits from anti-EGFR rechallenge (HR: 0.41; 95% CI 0.28-0.60, I² = 60%). Common grade 3 or higher treatment-related adverse events included neutropenia (22.8%) and rash (14.9%).CONCLUSIONThis meta-analysis underscores the efficacy and safety of anti-EGFR rechallenge as a promising therapeutic approach for a subset of patients afflicted with mCRC. The observed correlation between wild-type RAS status, as determined through ctDNA analysis, and improved OS signals the prospect of precision oncology in guiding treatment decisions.

01 Aug 2025·IEEE Transactions on Applied Superconductivity

Comparison of Flux-Trapped Superconducting Machine Configurations

Author: Dias, Fernando Jorge Monteiro ; Schoenacher, Ricardo Rezende ; Sotelo, Guilherme Gonçalves ; Santos, Gabriel dos ; Trillaud, Frederic ; Carvalho, Gabriel Borges Carreiro

100 Deals associated with Universidade Federal Fluminense

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100 Translational Medicine associated with Universidade Federal Fluminense

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Pipeline

Pipeline Snapshot as of 05 Feb 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

LASSBio-1425 ( TNF-α )	Hypertriglyceridemia More	Preclinical
Recombinant Human Fibroblast Growth Factor-2(SVS Institute of Dental Sciences) ( FGFR1 x FGFR2 )	Aggressive Periodontitis More	Pending